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The presence of migraines and its association with sensory hyperreactivity and anxiety symptomatology in children with autism spectrum disorder / Jillian C SULLIVAN in Autism, 18-6 (August 2014)
[article]
Titre : The presence of migraines and its association with sensory hyperreactivity and anxiety symptomatology in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jillian C SULLIVAN, Auteur ; Lucy J MILLER, Auteur ; Darcy M NIELSEN, Auteur ; Sarah A. SCHOEN, Auteur Article en page(s) : p.743-747 Langues : Anglais (eng) Mots-clés : anxiety autism hyperreactivity migraines sensory processing Index. décimale : PER Périodiques Résumé : Migraine headaches are associated with sensory hyperreactivity and anxiety in the general population, but it is unknown whether this is also the case in autism spectrum disorders. This pilot study asked parents of 81 children (aged 7–17 years) with autism spectrum disorders to report their child’s migraine occurrence, sensory hyperreactivity (Sensory Over-Responsivity Inventory), and anxiety symptoms (Spence Child Anxiety Scale). Children with autism spectrum disorders who experienced migraine headaches showed greater sensory hyperreactivity and anxiety symptomatology (p 0.01; medium effect size for both) than those without migraines. Sensory hyperreactivity and anxiety symptomatology were additionally correlated (? = 0.31, p = 0.005). This study provides preliminary evidence for a link between migraine headaches, sensory hyperreactivity, and anxiety symptomatology in autism spectrum disorders, which may suggest strategies for subtyping and exploring a common pathogenesis. En ligne : http://dx.doi.org/10.1177/1362361313489377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237
in Autism > 18-6 (August 2014) . - p.743-747[article] The presence of migraines and its association with sensory hyperreactivity and anxiety symptomatology in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Jillian C SULLIVAN, Auteur ; Lucy J MILLER, Auteur ; Darcy M NIELSEN, Auteur ; Sarah A. SCHOEN, Auteur . - p.743-747.
Langues : Anglais (eng)
in Autism > 18-6 (August 2014) . - p.743-747
Mots-clés : anxiety autism hyperreactivity migraines sensory processing Index. décimale : PER Périodiques Résumé : Migraine headaches are associated with sensory hyperreactivity and anxiety in the general population, but it is unknown whether this is also the case in autism spectrum disorders. This pilot study asked parents of 81 children (aged 7–17 years) with autism spectrum disorders to report their child’s migraine occurrence, sensory hyperreactivity (Sensory Over-Responsivity Inventory), and anxiety symptoms (Spence Child Anxiety Scale). Children with autism spectrum disorders who experienced migraine headaches showed greater sensory hyperreactivity and anxiety symptomatology (p 0.01; medium effect size for both) than those without migraines. Sensory hyperreactivity and anxiety symptomatology were additionally correlated (? = 0.31, p = 0.005). This study provides preliminary evidence for a link between migraine headaches, sensory hyperreactivity, and anxiety symptomatology in autism spectrum disorders, which may suggest strategies for subtyping and exploring a common pathogenesis. En ligne : http://dx.doi.org/10.1177/1362361313489377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237 Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice / R. T. MOLENHUIS in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)
[article]
Titre : Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice Type de document : Texte imprimé et/ou numérique Auteurs : R. T. MOLENHUIS, Auteur ; Hilgo BRUINING, Auteur ; E. REMMELINK, Auteur ; L. DE VISSER, Auteur ; M. LOOS, Auteur ; J. P. H. BURBACH, Auteur ; M. J. KAS, Auteur Article en page(s) : p.6 Langues : Anglais (eng) Mots-clés : 3p deletion syndrome Autism spectrum disorder Behavior Cntn4 Developmental trajectories Hyperreactivity Mouse model Negative findings Reversal learning Schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Mouse models offer an essential tool to unravel the impact of genetic mutations on autism-related phenotypes. The behavioral impact of some important candidate gene models for autism spectrum disorder (ASD) has not yet been studied, and existing characterizations mostly describe behavioral phenotypes at adult ages, disregarding the developmental nature of the disorder. In this context, the behavioral influence of CNTN4, one of the strongest suggested ASD candidate genes, is unknown. Here, we used our recently established developmental test battery to characterize the consequences of disruption of contactin 4 (Cntn4) on neurological, sensory, cognitive, and behavioral phenotypes across different developmental stages. METHODS: C57BL/6J mice with heterozygous and homozygous disruption of Cntn4 were studied through an extensive, partially longitudinal, test battery at various developmental stages, including various paradigms testing social and restricted repetitive behaviors. RESULTS: Developmental neurological and cognitive screenings revealed no significant differences between genotypes, and ASD-related behavioral domains were also unchanged in Cntn4-deficient versus wild-type mice. The impact of Cntn4-deficiency was found to be limited to increased startle responsiveness following auditory stimuli of different high amplitudes in heterozygous and homozygous Cntn4-deficient mice and enhanced acquisition in a spatial learning task in homozygous mice. CONCLUSIONS: Disruption of Cntn4 in the C57BL/6J background does not affect specific autism-related phenotypes in developing or adult mice but causes subtle non-disorder specific changes in sensory behavioral responses and cognitive performance. En ligne : http://dx.doi.org/10.1186/s11689-016-9140-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.6[article] Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice [Texte imprimé et/ou numérique] / R. T. MOLENHUIS, Auteur ; Hilgo BRUINING, Auteur ; E. REMMELINK, Auteur ; L. DE VISSER, Auteur ; M. LOOS, Auteur ; J. P. H. BURBACH, Auteur ; M. J. KAS, Auteur . - p.6.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.6
Mots-clés : 3p deletion syndrome Autism spectrum disorder Behavior Cntn4 Developmental trajectories Hyperreactivity Mouse model Negative findings Reversal learning Schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Mouse models offer an essential tool to unravel the impact of genetic mutations on autism-related phenotypes. The behavioral impact of some important candidate gene models for autism spectrum disorder (ASD) has not yet been studied, and existing characterizations mostly describe behavioral phenotypes at adult ages, disregarding the developmental nature of the disorder. In this context, the behavioral influence of CNTN4, one of the strongest suggested ASD candidate genes, is unknown. Here, we used our recently established developmental test battery to characterize the consequences of disruption of contactin 4 (Cntn4) on neurological, sensory, cognitive, and behavioral phenotypes across different developmental stages. METHODS: C57BL/6J mice with heterozygous and homozygous disruption of Cntn4 were studied through an extensive, partially longitudinal, test battery at various developmental stages, including various paradigms testing social and restricted repetitive behaviors. RESULTS: Developmental neurological and cognitive screenings revealed no significant differences between genotypes, and ASD-related behavioral domains were also unchanged in Cntn4-deficient versus wild-type mice. The impact of Cntn4-deficiency was found to be limited to increased startle responsiveness following auditory stimuli of different high amplitudes in heterozygous and homozygous Cntn4-deficient mice and enhanced acquisition in a spatial learning task in homozygous mice. CONCLUSIONS: Disruption of Cntn4 in the C57BL/6J background does not affect specific autism-related phenotypes in developing or adult mice but causes subtle non-disorder specific changes in sensory behavioral responses and cognitive performance. En ligne : http://dx.doi.org/10.1186/s11689-016-9140-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348