98 recherche sur le mot-clé 'Int�r�ts'

Assessing autistic traits: cross-cultural validation of the social responsiveness scale (SRS) / Sven BÖLTE in Autism Research, 1-6 (December 2008)  

Public ISBD [article]  inAutism Research > 1-6 (December 2008) . - p.354-363 Titre : Assessing autistic traits: cross-cultural validation of the social responsiveness scale (SRS) Type de document : texte imprimé Auteurs : Sven BÖLTE, Auteur ; Fritz POUSTKA, Auteur ; John N. CONSTANTINO, Auteur Année de publication : 2008 Article en page(s) : p.354-363 Langues : Anglais (eng) Mots-clés : autism PDD psychometrics ADI-R ADOS SCQ TCI CBCL Index. décimale : PER Périodiques Résumé : The Social Responsiveness Scale (SRS) is a quantitative measure of autistic traits in 4- to 18-year-olds, which has been used in behavior-genetic, epidemiological and intervention studies. The US standardization demonstrated a single-factor structure and good to excellent psychometric properties. The cross-cultural validity of the German adaptation of the parent-report SRS in a sample of N=1,436 children and adolescents: 838 typically developing and 527 clinical participants (160 with autism spectrum disorders (ASDs)) was examined. Internal consistency (0.91-0.97), test-retest reliability (0.84-0.97), interrater reliability (0.76 and 0.95) and convergent validity with the Autism Diagnostic Observation Schedule as well as the Autism Diagnostic Interview - Revised and Social Communication Questionnaire (0.35-0.58) were satisfactory to good. The SRS total score discriminated between ASD and other mental disorders. SRS scores proved to be sufficiently independent of general psychopathology. Principal component analyses yielded single-factor solutions for the normative and clinical subsamples. In addition, construct validity was ensured by consistent correlations with the Vineland Adaptive Behavior Scales, the Child Behavior Checklist and the Junior Temperament and Character Inventory. Normative SRS total scores for girls and boys as well as values for ASD were lower in the German sample, while scores for conduct disorder and attention deficit hyperactivity/conduct disorder combined were higher. Generally, cross-cultural validity of the SRS seems to be sufficiently assured for a large European sample. However, some discrepancies regarding SRS normative and clinical raw score distributions, reliability and validity findings are critically discussed. En ligne : http://dx.doi.org/10.1002/aur.49 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934 [article] Assessing autistic traits: cross-cultural validation of the social responsiveness scale (SRS) [texte imprimé] / Sven BÖLTE, Auteur ; Fritz POUSTKA, Auteur ; John N. CONSTANTINO, Auteur . - 2008 . - p.354-363. Langues : Anglais (eng) in Autism Research > 1-6 (December 2008) . - p.354-363 Mots-clés : autism PDD psychometrics ADI-R ADOS SCQ TCI CBCL Index. décimale : PER Périodiques Résumé : The Social Responsiveness Scale (SRS) is a quantitative measure of autistic traits in 4- to 18-year-olds, which has been used in behavior-genetic, epidemiological and intervention studies. The US standardization demonstrated a single-factor structure and good to excellent psychometric properties. The cross-cultural validity of the German adaptation of the parent-report SRS in a sample of N=1,436 children and adolescents: 838 typically developing and 527 clinical participants (160 with autism spectrum disorders (ASDs)) was examined. Internal consistency (0.91-0.97), test-retest reliability (0.84-0.97), interrater reliability (0.76 and 0.95) and convergent validity with the Autism Diagnostic Observation Schedule as well as the Autism Diagnostic Interview - Revised and Social Communication Questionnaire (0.35-0.58) were satisfactory to good. The SRS total score discriminated between ASD and other mental disorders. SRS scores proved to be sufficiently independent of general psychopathology. Principal component analyses yielded single-factor solutions for the normative and clinical subsamples. In addition, construct validity was ensured by consistent correlations with the Vineland Adaptive Behavior Scales, the Child Behavior Checklist and the Junior Temperament and Character Inventory. Normative SRS total scores for girls and boys as well as values for ASD were lower in the German sample, while scores for conduct disorder and attention deficit hyperactivity/conduct disorder combined were higher. Generally, cross-cultural validity of the SRS seems to be sufficiently assured for a large European sample. However, some discrepancies regarding SRS normative and clinical raw score distributions, reliability and validity findings are critically discussed. En ligne : http://dx.doi.org/10.1002/aur.49 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=934

Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index / Carla B. KALVIN in Journal of Autism and Developmental Disorders, 51-5 (May 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-5 (May 2021) . - p.1496-1507 Titre : Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index Type de document : texte imprimé Auteurs : Carla B. KALVIN, Auteur ; Theresa R. GLADSTONE, Auteur ; Rebecca JORDAN, Auteur ; Sonia ROWLEY, Auteur ; Carolyn L. MARSH, Auteur ; Karim IBRAHIM, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.1496-1507 Langues : Anglais (eng) Mots-clés : Anxiety  Autism spectrum disorder  Irritability  Noncompliance  treatment manual on CBT for anger and aggression in children. Other authors (C.B.K.,  T.R.G., R.J., S.R., C.L.M. and K.I.) have no biomedical financial interests or  potential conflicts of interest to declare related to this present study. Index. décimale : PER Périodiques Résumé : Irritability is an impairing problem in children with ASD that may be associated with other behavioral and emotional concerns. The Affective Reactivity Index (ARI) is a parent-rated measure of irritability widely used in children with mood disorders, however, its utility in children with ASD remains unclear. In this study, we examined ARI parent ratings in children with ASD and contributions of parent-rated anxiety and noncompliance to irritability measured by the ARI. Participants included 81 children with ASD, aged 8-16 years. Results suggest that both anxiety and noncompliance contribute to irritability, but that anxiety only contributes to irritability in the absence of noncompliance. Further, the ARI is likely to be a useful measure of irritability in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04627-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index [texte imprimé] / Carla B. KALVIN, Auteur ; Theresa R. GLADSTONE, Auteur ; Rebecca JORDAN, Auteur ; Sonia ROWLEY, Auteur ; Carolyn L. MARSH, Auteur ; Karim IBRAHIM, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.1496-1507. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-5 (May 2021) . - p.1496-1507 Mots-clés : Anxiety  Autism spectrum disorder  Irritability  Noncompliance  treatment manual on CBT for anger and aggression in children. Other authors (C.B.K.,  T.R.G., R.J., S.R., C.L.M. and K.I.) have no biomedical financial interests or  potential conflicts of interest to declare related to this present study. Index. décimale : PER Périodiques Résumé : Irritability is an impairing problem in children with ASD that may be associated with other behavioral and emotional concerns. The Affective Reactivity Index (ARI) is a parent-rated measure of irritability widely used in children with mood disorders, however, its utility in children with ASD remains unclear. In this study, we examined ARI parent ratings in children with ASD and contributions of parent-rated anxiety and noncompliance to irritability measured by the ARI. Participants included 81 children with ASD, aged 8-16 years. Results suggest that both anxiety and noncompliance contribute to irritability, but that anxiety only contributes to irritability in the absence of noncompliance. Further, the ARI is likely to be a useful measure of irritability in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04627-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome / Elizabeth BERRY-KRAVIS ; Mark D. HARNETT ; Scott A. REINES ; Melody A REESE ; Abigail H OUTTERSON ; Claire MICHALAK ; Jeremiah FURMAN ; Mark E. GURNEY ; Lauren E ETHRIDGE in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 47 Titre : Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome Type de document : texte imprimé Auteurs : Elizabeth BERRY-KRAVIS, Auteur ; Mark D. HARNETT, Auteur ; Scott A. REINES, Auteur ; Melody A REESE, Auteur ; Abigail H OUTTERSON, Auteur ; Claire MICHALAK, Auteur ; Jeremiah FURMAN, Auteur ; Mark E. GURNEY, Auteur ; Lauren E ETHRIDGE, Auteur Article en page(s) : 47 Langues : Anglais (eng) Mots-clés : Adult  Humans  Male  Middle Aged  Young Adult  Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism  *Electroencephalography  Evoked Potentials  Evoked Potentials, Auditory/drug effects  *Fragile X Syndrome/blood/drug therapy/physiopathology  Biomarker  Eeg  Fragile X syndrome  Pharmacokinetics  Zatolmilast  interests. M.D.H.and S.D.R. are paid consultants to Tetra Therapeutics. M.E.G. is  an employee of TetraTherapeutics, which is a wholly owned subsidiary of Shionogi  & Co., Ltd that has a financial interest in BPN14770. Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by a CGG repeat expansion ? 200 repeats in 5' untranslated region of the FMR1 gene, leading to intellectual disability and cognitive difficulties, including in the domain of communication. A recent phase 2a clinical trial testing BPN14770, a phosphodiesterase 4D inhibitor, showed improved cognition in 30 adult males with FXS on drug relative to placebo. The initial study found significant improvements in clinical measures assessing cognition, language, and daily functioning in addition to marginal improvements in electroencephalography (EEG) results for the amplitude of the N1 event-related potential (ERP) component. These EEG results suggest BPN14770 improved neural hyperexcitability in FXS. The current study investigated the relationship between BPN14770 pharmacokinetics and the amplitude of the N1 ERP component from the initial data. Consistent with the original group-level finding post-period 1 of the study, participants who received BPN14770 in period 1 showed a significant correlation between N1 amplitude and serum concentration of BPN14770 measured at the end of period 1. These findings strengthen the validity of the original result, indicating that BPN14770 improves cognitive performance by modulating neural hyperexcitability. This study represents the first report of a significant correlation between a reliably abnormal EEG marker and serum concentration of a novel pharmaceutical in FXS. En ligne : https://dx.doi.org/10.1186/s13229-024-00626-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome [texte imprimé] / Elizabeth BERRY-KRAVIS, Auteur ; Mark D. HARNETT, Auteur ; Scott A. REINES, Auteur ; Melody A REESE, Auteur ; Abigail H OUTTERSON, Auteur ; Claire MICHALAK, Auteur ; Jeremiah FURMAN, Auteur ; Mark E. GURNEY, Auteur ; Lauren E ETHRIDGE, Auteur . - 47. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 47 Mots-clés : Adult  Humans  Male  Middle Aged  Young Adult  Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism  *Electroencephalography  Evoked Potentials  Evoked Potentials, Auditory/drug effects  *Fragile X Syndrome/blood/drug therapy/physiopathology  Biomarker  Eeg  Fragile X syndrome  Pharmacokinetics  Zatolmilast  interests. M.D.H.and S.D.R. are paid consultants to Tetra Therapeutics. M.E.G. is  an employee of TetraTherapeutics, which is a wholly owned subsidiary of Shionogi  & Co., Ltd that has a financial interest in BPN14770. Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by a CGG repeat expansion ? 200 repeats in 5' untranslated region of the FMR1 gene, leading to intellectual disability and cognitive difficulties, including in the domain of communication. A recent phase 2a clinical trial testing BPN14770, a phosphodiesterase 4D inhibitor, showed improved cognition in 30 adult males with FXS on drug relative to placebo. The initial study found significant improvements in clinical measures assessing cognition, language, and daily functioning in addition to marginal improvements in electroencephalography (EEG) results for the amplitude of the N1 event-related potential (ERP) component. These EEG results suggest BPN14770 improved neural hyperexcitability in FXS. The current study investigated the relationship between BPN14770 pharmacokinetics and the amplitude of the N1 ERP component from the initial data. Consistent with the original group-level finding post-period 1 of the study, participants who received BPN14770 in period 1 showed a significant correlation between N1 amplitude and serum concentration of BPN14770 measured at the end of period 1. These findings strengthen the validity of the original result, indicating that BPN14770 improves cognitive performance by modulating neural hyperexcitability. This study represents the first report of a significant correlation between a reliably abnormal EEG marker and serum concentration of a novel pharmaceutical in FXS. En ligne : https://dx.doi.org/10.1186/s13229-024-00626-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Autism Diagnostic Interview-Revised Within DSM-5 Framework: Test of Reliability and Validity in Chinese Children / Kelly Y.C. LAI in Journal of Autism and Developmental Disorders, 52-4 (April 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1807-1820 Titre : Autism Diagnostic Interview-Revised Within DSM-5 Framework: Test of Reliability and Validity in Chinese Children Type de document : texte imprimé Auteurs : Kelly Y.C. LAI, Auteur ; Emily C.W. YUEN, Auteur ; Se-fong HUNG, Auteur ; Patrick W.L. LEUNG, Auteur Article en page(s) : p.1807-1820 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  China  Diagnostic and Statistical Manual of Mental Disorders  Humans  Reproducibility of Results  Adhd  Adi-r  Chinese  Dsm-5  Validity Index. décimale : PER Périodiques Résumé : This study examines the psychometric properties of the Autism Diagnostic Interview-Revised (ADI-R) in the context of DSM-5 in a sample of Chinese children. Using re-mapped ADI-R items and algorithms matched to DSM-5 criteria, and administering to children with autism spectrum disorder (ASD) with and without intellectual disability, attention-deficit hyperactivity disorder, and typically developing, it evidenced high sensitivity and specificity. However, similar to DSM-IV algorithm, the DSM-5 algorithms were better at classifying ASD among children with intellectual disability than among those without intellectual disability. With the DSM-5's recognition of the spectrum nature of ASD, the performance of the ADI-R can be improved by having finer gradations in the ADI-R scoring and adding more items on the restricted and repetitve behavior domain. En ligne : http://dx.doi.org/10.1007/s10803-021-05079-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Autism Diagnostic Interview-Revised Within DSM-5 Framework: Test of Reliability and Validity in Chinese Children [texte imprimé] / Kelly Y.C. LAI, Auteur ; Emily C.W. YUEN, Auteur ; Se-fong HUNG, Auteur ; Patrick W.L. LEUNG, Auteur . - p.1807-1820. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-4 (April 2022) . - p.1807-1820 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  China  Diagnostic and Statistical Manual of Mental Disorders  Humans  Reproducibility of Results  Adhd  Adi-r  Chinese  Dsm-5  Validity Index. décimale : PER Périodiques Résumé : This study examines the psychometric properties of the Autism Diagnostic Interview-Revised (ADI-R) in the context of DSM-5 in a sample of Chinese children. Using re-mapped ADI-R items and algorithms matched to DSM-5 criteria, and administering to children with autism spectrum disorder (ASD) with and without intellectual disability, attention-deficit hyperactivity disorder, and typically developing, it evidenced high sensitivity and specificity. However, similar to DSM-IV algorithm, the DSM-5 algorithms were better at classifying ASD among children with intellectual disability than among those without intellectual disability. With the DSM-5's recognition of the spectrum nature of ASD, the performance of the ADI-R can be improved by having finer gradations in the ADI-R scoring and adding more items on the restricted and repetitve behavior domain. En ligne : http://dx.doi.org/10.1007/s10803-021-05079-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Autism Screening in High-Likelihood Children in a Community Early Intervention Setting: A Hybrid Effectiveness-Implementation Study / Georgina PEREZ LIZ in Focus on Autism and Other Developmental Disabilities, 40-3 (September 2025)  

Public ISBD [article]  inFocus on Autism and Other Developmental Disabilities > 40-3 (September 2025) . - p.145-153 Titre : Autism Screening in High-Likelihood Children in a Community Early Intervention Setting: A Hybrid Effectiveness-Implementation Study Type de document : texte imprimé Auteurs : Georgina PEREZ LIZ, Auteur ; Diana THAO, Auteur ; Katelyn REEB, Auteur ; Ilene GOY, Auteur ; Erin E. MCCURDY, Auteur ; Michael YUDELL, Auteur ; Diana L. ROBINS, Auteur Article en page(s) : p.145-153 Langues : Anglais (eng) Mots-clés : autism  autism screening  M-CHAT-R/F  early intervention  community setting  effectiveness-implementation Index. décimale : PER Périodiques Résumé : Identification of likelihood for autism in the U.S. early intervention (EI) system facilitates referrals to diagnostic assessments and targets autism-specific needs. However, performance of autism screeners in high-likelihood preschool children and barriers to implementation need to be further studied. The current effectiveness-implementation hybrid type 1 study examined the impact of administering the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) in a sample of preschool children during the EI intake phone call. Data from 2,661 educational records showed that 42.8% of them received the M-CHAT-R. Only 14.0% of the screen-positive children completing the process to determine eligibility for EI services were referred for an autism-specific evaluation. Most of these (94.8%), regardless of screener status, received an autism diagnosis, suggesting that referrals are based on clinical judgment. Training and incorporation to current protocols within agencies are necessary to introduce a screening tool and support implementation fidelity and effective autism detection. En ligne : https://dx.doi.org/10.1177/10883576241308544 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566 [article] Autism Screening in High-Likelihood Children in a Community Early Intervention Setting: A Hybrid Effectiveness-Implementation Study [texte imprimé] / Georgina PEREZ LIZ, Auteur ; Diana THAO, Auteur ; Katelyn REEB, Auteur ; Ilene GOY, Auteur ; Erin E. MCCURDY, Auteur ; Michael YUDELL, Auteur ; Diana L. ROBINS, Auteur . - p.145-153. Langues : Anglais (eng) in Focus on Autism and Other Developmental Disabilities > 40-3 (September 2025) . - p.145-153 Mots-clés : autism  autism screening  M-CHAT-R/F  early intervention  community setting  effectiveness-implementation Index. décimale : PER Périodiques Résumé : Identification of likelihood for autism in the U.S. early intervention (EI) system facilitates referrals to diagnostic assessments and targets autism-specific needs. However, performance of autism screeners in high-likelihood preschool children and barriers to implementation need to be further studied. The current effectiveness-implementation hybrid type 1 study examined the impact of administering the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) in a sample of preschool children during the EI intake phone call. Data from 2,661 educational records showed that 42.8% of them received the M-CHAT-R. Only 14.0% of the screen-positive children completing the process to determine eligibility for EI services were referred for an autism-specific evaluation. Most of these (94.8%), regardless of screener status, received an autism diagnosis, suggesting that referrals are based on clinical judgment. Training and incorporation to current protocols within agencies are necessary to introduce a screening tool and support implementation fidelity and effective autism detection. En ligne : https://dx.doi.org/10.1177/10883576241308544 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566

Autism Spectrum Disorder in the DSM-5: Diagnostic Sensitivity and Specificity in Early Childhood / Jessica A. CHRISTIANSZ in Journal of Autism and Developmental Disorders, 46-6 (June 2016)  

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Autism spectrum disorder in the second year: stability and change in syndrome expression / Katarzyna CHAWARSKA in Journal of Child Psychology and Psychiatry, 48-2 (February 2007)  

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Autism spectrum disorder symptom expression in individuals with 3q29 deletion syndrome / Rebecca M. POLLAK in Molecular Autism, 13 (2022)  

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Autism Spectrum Phenotype in Males and Females with Fragile X Full Mutation and Premutation / Sally M. CLIFFORD in Journal of Autism and Developmental Disorders, 37-4 (April 2007)  

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Autism Spectrum Traits in Children with Anxiety Disorders / Francisca J.A. STEENSEL in Journal of Autism and Developmental Disorders, 43-2 (February 2013)  

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