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Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort / Novika Purnama SARI in Molecular Autism, 13 (2022)
[article]
Titre : Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort Type de document : Texte imprimé et/ou numérique Auteurs : Novika Purnama SARI, Auteur ; Pauline W. JANSEN, Auteur ; Laura M. E. BLANKEN, Auteur ; Amber N. V. RUIGROK, Auteur ; Peter PRINZIE, Auteur ; Henning TIEMEIER, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Tonya WHITE, Auteur Article en page(s) : 26 p. Langues : Anglais (eng) Mots-clés : Autistic Disorder/epidemiology Child Female Humans Male Maternal Age Mentalization Mothers Netherlands/epidemiology Pregnancy Autistic-like traits Children Mentalizing Index. décimale : PER Périodiques Résumé : BACKGROUND: Many empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring. METHODS: In a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M(agechild)=13.5 years; 50.2% girls). RESULTS: The relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers. CONCLUSIONS: The relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-022-00507-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Molecular Autism > 13 (2022) . - 26 p.[article] Maternal age, autistic-like traits and mentalizing as predictors of child autistic-like traits in a population-based cohort [Texte imprimé et/ou numérique] / Novika Purnama SARI, Auteur ; Pauline W. JANSEN, Auteur ; Laura M. E. BLANKEN, Auteur ; Amber N. V. RUIGROK, Auteur ; Peter PRINZIE, Auteur ; Henning TIEMEIER, Auteur ; Simon BARON-COHEN, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Tonya WHITE, Auteur . - 26 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 26 p.
Mots-clés : Autistic Disorder/epidemiology Child Female Humans Male Maternal Age Mentalization Mothers Netherlands/epidemiology Pregnancy Autistic-like traits Children Mentalizing Index. décimale : PER Périodiques Résumé : BACKGROUND: Many empirical studies suggest that higher maternal age increases the likelihood of having an autistic child. However, little is known about factors that may explain this relationship or if higher maternal age is related to the number of autistic-like traits in offspring. One possibility is that mothers who have a higher number of autistic-like traits, including greater challenges performing mentalizing skills, are delayed in finding a partner. The goal of our study is to assess the relationship between maternal age, mentalizing skills and autistic-like traits as independent predictors of the number of autistic-like traits in offspring. METHODS: In a population-based study in the Netherlands, information on maternal age was collected during pre- and perinatal enrolment. Maternal mentalizing skills and autistic-like traits were assessed using the Reading the Mind in the Eyes Test and the Autism Spectrum Quotient, respectively. Autistic-like traits in children were assessed with the Social Responsiveness Scale. A total of 5718 mother/child dyads had complete data (M(agechild)=13.5 years; 50.2% girls). RESULTS: The relationship between maternal age and autistic-like traits in offspring best fits a U-shaped curve. Furthermore, higher levels of autistic features in mothers are linked to higher levels of autistic-like traits in their children. Lower mentalizing performance in mothers is linked to higher levels of autistic-like traits in their children. LIMITATIONS: We were able to collect data on both autistic-like traits and the mentalizing skills test in a large population of mothers, but we did not collect these data in a large number of the fathers. CONCLUSIONS: The relationships between older and younger mothers may have comparable underlying mechanisms, but it is also possible that the tails of the U-shaped curve are influenced by disparate mechanisms. En ligne : http://dx.doi.org/10.1186/s13229-022-00507-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica / Mohammad Hossein RAHBAR in Journal of Autism and Developmental Disorders, 42-9 (September 2012)
[article]
Titre : Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad Hossein RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Zhongxue CHEN, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Compton BEECHER, Auteur ; Kari BLOOM, Auteur ; Eric BOERWINKLE, Auteur Année de publication : 2012 Article en page(s) : p.1928-1938 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Maternal age Paternal age Multivariate General Linear Models Multicollinearity Index. décimale : PER Périodiques Résumé : Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. En ligne : http://dx.doi.org/10.1007/s10803-011-1438-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180
in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1928-1938[article] Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica [Texte imprimé et/ou numérique] / Mohammad Hossein RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Katherine A. LOVELAND, Auteur ; Deborah A. PEARSON, Auteur ; Jan BRESSLER, Auteur ; Zhongxue CHEN, Auteur ; Manouchehr ARDJOMAND-HESSABI, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Compton BEECHER, Auteur ; Kari BLOOM, Auteur ; Eric BOERWINKLE, Auteur . - 2012 . - p.1928-1938.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-9 (September 2012) . - p.1928-1938
Mots-clés : Autism spectrum disorders Maternal age Paternal age Multivariate General Linear Models Multicollinearity Index. décimale : PER Périodiques Résumé : Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM. En ligne : http://dx.doi.org/10.1007/s10803-011-1438-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 Brief Report: Phenotypic Differences and their Relationship to Paternal Age and Gender in Autism Spectrum Disorder / Esther VIERCK in Journal of Autism and Developmental Disorders, 45-6 (June 2015)
[article]
Titre : Brief Report: Phenotypic Differences and their Relationship to Paternal Age and Gender in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Esther VIERCK, Auteur ; Jeremy M. SILVERMAN, Auteur Article en page(s) : p.1915-1924 Langues : Anglais (eng) Mots-clés : Autism De novo mutations Paternal age Phenotype Maternal age Index. décimale : PER Périodiques Résumé : Two modes of inheritance have been proposed in autism spectrum disorder, transmission though pre-existing variants and de novo mutations. Different modes may lead to different symptom expressions in affected individuals. De novo mutations become more likely with advancing paternal age suggesting that paternal age may predict phenotypic differences. To test this possibility we measured IQ, adaptive behavior, and autistic symptoms in 830 probands from simplex families. We conducted multiple linear regression analysis to estimate the predictive value of paternal age, maternal age, and gender on behavioral measures and IQ. We found a differential effect of parental age and sex on repetitive and restricted behaviors. Findings suggest effects of paternal age on phenotypic differences in simplex families with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2346-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1915-1924[article] Brief Report: Phenotypic Differences and their Relationship to Paternal Age and Gender in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Esther VIERCK, Auteur ; Jeremy M. SILVERMAN, Auteur . - p.1915-1924.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1915-1924
Mots-clés : Autism De novo mutations Paternal age Phenotype Maternal age Index. décimale : PER Périodiques Résumé : Two modes of inheritance have been proposed in autism spectrum disorder, transmission though pre-existing variants and de novo mutations. Different modes may lead to different symptom expressions in affected individuals. De novo mutations become more likely with advancing paternal age suggesting that paternal age may predict phenotypic differences. To test this possibility we measured IQ, adaptive behavior, and autistic symptoms in 830 probands from simplex families. We conducted multiple linear regression analysis to estimate the predictive value of paternal age, maternal age, and gender on behavioral measures and IQ. We found a differential effect of parental age and sex on repetitive and restricted behaviors. Findings suggest effects of paternal age on phenotypic differences in simplex families with ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2346-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259 No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children / Karson T. F. KUNG in Molecular Autism, 7 (2016)
[article]
Titre : No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children Type de document : Texte imprimé et/ou numérique Auteurs : Karson T. F. KUNG, Auteur ; M. CONSTANTINESCU, Auteur ; W. V. BROWNE, Auteur ; R. M. NOORDERHAVEN, Auteur ; M. HINES, Auteur Article en page(s) : 15p. Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/metabolism/psychology Birth Weight Child Development Child, Preschool Female Humans Infant Male Maternal Age Parents/education Paternal Age Risk Factors Saliva/chemistry Siblings Surveys and Questionnaires Symptom Assessment Testosterone/analysis Autism Gender differences Postnatal development Sex differences Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Some previous research has suggested that testosterone prenatally contributes to gender differences in autistic traits, but little is known about the role of testosterone during early postnatal development (mini-puberty). Two prior studies found no sex difference in testosterone postnatally in saliva samples and detected little to no relationship between testosterone postnatally and autistic traits in toddlers. These findings may reflect late measurements of testosterone at 3 to 4 months of age, after the peak of mini-puberty at 1 to 3 months of age. The present study examined the relationship between testosterone at 1 to 3 months of age and autistic traits at 18 to 30 months of age. FINDINGS: Testosterone was measured in saliva samples collected from children at 1 to 3 months of age. When the children (40 boys, 47 girls) reached 18 to 30 months of age, parents completed the Quantitative Checklist for Autism in Toddlers (Q-CHAT). Boys had higher concentrations of testosterone postnatally and higher Q-CHAT scores than girls. However, testosterone did not correlate with Q-CHAT scores in boys, girls, or the entire sample. CONCLUSIONS: The current results suggest that testosterone during the early postnatal period does not contribute to later autistic traits. Given our relatively small samples and therefore limited power, however, further research could usefully examine if testosterone in saliva samples collected during the peak of mini-puberty in larger groups predicts autistic traits or other traits that show gender differences. En ligne : http://dx.doi.org/10.1186/s13229-016-0078-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 15p.[article] No relationship between early postnatal testosterone concentrations and autistic traits in 18 to 30-month-old children [Texte imprimé et/ou numérique] / Karson T. F. KUNG, Auteur ; M. CONSTANTINESCU, Auteur ; W. V. BROWNE, Auteur ; R. M. NOORDERHAVEN, Auteur ; M. HINES, Auteur . - 15p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 15p.
Mots-clés : Adult Autism Spectrum Disorder/metabolism/psychology Birth Weight Child Development Child, Preschool Female Humans Infant Male Maternal Age Parents/education Paternal Age Risk Factors Saliva/chemistry Siblings Surveys and Questionnaires Symptom Assessment Testosterone/analysis Autism Gender differences Postnatal development Sex differences Testosterone Index. décimale : PER Périodiques Résumé : BACKGROUND: Some previous research has suggested that testosterone prenatally contributes to gender differences in autistic traits, but little is known about the role of testosterone during early postnatal development (mini-puberty). Two prior studies found no sex difference in testosterone postnatally in saliva samples and detected little to no relationship between testosterone postnatally and autistic traits in toddlers. These findings may reflect late measurements of testosterone at 3 to 4 months of age, after the peak of mini-puberty at 1 to 3 months of age. The present study examined the relationship between testosterone at 1 to 3 months of age and autistic traits at 18 to 30 months of age. FINDINGS: Testosterone was measured in saliva samples collected from children at 1 to 3 months of age. When the children (40 boys, 47 girls) reached 18 to 30 months of age, parents completed the Quantitative Checklist for Autism in Toddlers (Q-CHAT). Boys had higher concentrations of testosterone postnatally and higher Q-CHAT scores than girls. However, testosterone did not correlate with Q-CHAT scores in boys, girls, or the entire sample. CONCLUSIONS: The current results suggest that testosterone during the early postnatal period does not contribute to later autistic traits. Given our relatively small samples and therefore limited power, however, further research could usefully examine if testosterone in saliva samples collected during the peak of mini-puberty in larger groups predicts autistic traits or other traits that show gender differences. En ligne : http://dx.doi.org/10.1186/s13229-016-0078-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328