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Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders / Irina MANOUILENKO in Research in Autism Spectrum Disorders, 7-5 (May 2013)
[article]
Titre : Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur Article en page(s) : p.566-578 Mots-clés : Autism spectrum disorder ADHD Neurological soft signs Temporo-parietal junction Thalamus Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194
in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578[article] Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur . - p.566-578.
in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578
Mots-clés : Autism spectrum disorder ADHD Neurological soft signs Temporo-parietal junction Thalamus Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 Longitudinal study of neurological soft signs in first-episode early-onset psychosis / María MAYORAL in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)
[article]
Titre : Longitudinal study of neurological soft signs in first-episode early-onset psychosis Type de document : Texte imprimé et/ou numérique Auteurs : María MAYORAL, Auteur ; I. BOMBIN, Auteur ; Josefina CASTRO-FORNIELES, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Soraya OTERO, Auteur ; Mara PARELLADA, Auteur ; Dolores MORENO, Auteur ; I. BAEZA, Auteur ; Montserrat GRAELL, Auteur ; Marta RAPADO, Auteur ; Celso ARANGO, Auteur Année de publication : 2012 Article en page(s) : p.323-331 Langues : Anglais (eng) Mots-clés : Neurological soft signs children and adolescents psychosis neurodevelopment Index. décimale : PER Périodiques Résumé : Background: In recent decades, the assessment of neurological soft signs (NSS) in patients with psychosis has become a subject of special interest. The study of the progression of NSS during adolescence will provide valuable information about the role of NSS as endophenotypes or biomarkers and about brain development at a stage in which brain maturation has not yet been completed. Methods: Neurological soft signs were assessed in a sample of 110 first episodes of early-onset psychosis (EOP) and 98 healthy children and adolescents at two different times in a 2-year follow-up period. Results: Patients with EOP showed more NSS than controls both at baseline (p < .001) and the 2-year follow-up (p < .001). No differences were found in the number of signs among the different diagnostic subgroups (schizophrenia, bipolar disorder, and other psychoses). When we examined the changes in NSS over the follow-up, the reduction of NSS in the patients was greater than the controls for ‘Motor coordination’ (p = .032), ‘Others’ (p < .001), and ‘Total score’ (p < .001) of the NES. Conclusion: Despite the greater reduction of NSS in patients than in controls along the follow-up, patients still have more neurological signs than healthy controls; therefore, these signs may be considered a trait marker. NSS do not seem to be specific to schizophrenia as they are present in different EOPs. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02475.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152
in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.323-331[article] Longitudinal study of neurological soft signs in first-episode early-onset psychosis [Texte imprimé et/ou numérique] / María MAYORAL, Auteur ; I. BOMBIN, Auteur ; Josefina CASTRO-FORNIELES, Auteur ; Ana GONZALEZ-PINTO, Auteur ; Soraya OTERO, Auteur ; Mara PARELLADA, Auteur ; Dolores MORENO, Auteur ; I. BAEZA, Auteur ; Montserrat GRAELL, Auteur ; Marta RAPADO, Auteur ; Celso ARANGO, Auteur . - 2012 . - p.323-331.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-3 (March 2012) . - p.323-331
Mots-clés : Neurological soft signs children and adolescents psychosis neurodevelopment Index. décimale : PER Périodiques Résumé : Background: In recent decades, the assessment of neurological soft signs (NSS) in patients with psychosis has become a subject of special interest. The study of the progression of NSS during adolescence will provide valuable information about the role of NSS as endophenotypes or biomarkers and about brain development at a stage in which brain maturation has not yet been completed. Methods: Neurological soft signs were assessed in a sample of 110 first episodes of early-onset psychosis (EOP) and 98 healthy children and adolescents at two different times in a 2-year follow-up period. Results: Patients with EOP showed more NSS than controls both at baseline (p < .001) and the 2-year follow-up (p < .001). No differences were found in the number of signs among the different diagnostic subgroups (schizophrenia, bipolar disorder, and other psychoses). When we examined the changes in NSS over the follow-up, the reduction of NSS in the patients was greater than the controls for ‘Motor coordination’ (p = .032), ‘Others’ (p < .001), and ‘Total score’ (p < .001) of the NES. Conclusion: Despite the greater reduction of NSS in patients than in controls along the follow-up, patients still have more neurological signs than healthy controls; therefore, these signs may be considered a trait marker. NSS do not seem to be specific to schizophrenia as they are present in different EOPs. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02475.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152