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Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions / Armando BERTONE in Journal of Autism and Developmental Disorders, 40-12 (December 2010)
[article]
Titre : Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur Année de publication : 2010 Article en page(s) : p.1531-1540 Langues : Anglais (eng) Mots-clés : Autism Fragile X syndrome Vision Perception Perceptual signatures Neural networks Index. décimale : PER Périodiques Résumé : The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevlopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In this paper and its companion paper, we propose a method for assessing the functional link between genotype and neural alteration across these target conditions by comparing their perceptual signatures. In the present paper, we discuss how such signatures can be used to (1) define and differentiate various aspects of neural functioning in autism and FXS, and subsequently, (2) to infer candidate causal (genetic) mechanisms based on such signatures (see companion paper, this issue). En ligne : http://dx.doi.org/10.1007/s10803-010-1109-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1531-1540[article] Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions [Texte imprimé et/ou numérique] / Armando BERTONE, Auteur ; Julie HANCK, Auteur ; Cary KOGAN, Auteur ; Avi CHAUDHURI, Auteur ; Kim CORNISH, Auteur . - 2010 . - p.1531-1540.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1531-1540
Mots-clés : Autism Fragile X syndrome Vision Perception Perceptual signatures Neural networks Index. décimale : PER Périodiques Résumé : The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevlopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In this paper and its companion paper, we propose a method for assessing the functional link between genotype and neural alteration across these target conditions by comparing their perceptual signatures. In the present paper, we discuss how such signatures can be used to (1) define and differentiate various aspects of neural functioning in autism and FXS, and subsequently, (2) to infer candidate causal (genetic) mechanisms based on such signatures (see companion paper, this issue). En ligne : http://dx.doi.org/10.1007/s10803-010-1109-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114