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Ethical dimensions of translational developmental neuroscience research in autism / A. MANZINI in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)
[article]
Titre : Ethical dimensions of translational developmental neuroscience research in autism Type de document : Texte imprimé et/ou numérique Auteurs : A. MANZINI, Auteur ; E. J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; M. ELSABBAGH, Auteur ; M. H. JOHNSON, Auteur ; I. SINGH, Auteur Article en page(s) : p.1363-1373 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/genetics Autistic Disorder Brain Child Early Intervention, Educational Humans Neurosciences Parents Autism biomarkers ethics genetics infant siblings neurodevelopment Ltd. and Servier and has received royalties from Sage Publications and Guilford Publications. Index. décimale : PER Périodiques Résumé : BACKGROUND: Since the 1990s, increasing research has been devoted to the identification of biomarkers for autism to help attain more objective diagnosis; enable early prediction of prognosis; and guide individualized intervention options. Early studies focused on the identification of genetic variants associated with autism, but more recently, research has expanded to investigate neurodevelopmental markers. While ethicists have extensively discussed issues around advances in autism genomics, much less ethical scrutiny has focused on research on early neurodevelopment and on the interventions being developed as a result. OBJECTIVES: We summarize the current state of the science on the identification of early markers for autism and its potential clinical applications, before providing an overview of the ethical issues arising from increasing understanding of children's neurodevelopment in very early life. RESULTS: Advances in the understanding of brain and behavioral trajectories preceding later autism diagnosis raise ethical concerns around three themes: (a) New models for understanding autism; (b) Risks and benefits of early identification and intervention; and (c) Communication of early concerns to families. These ethical issues should be further investigated in research conducted in partnership with autistic people and their families. CONCLUSIONS: This paper highlights the need for ethical scrutiny of early neurodevelopmental research in autism. Scrutiny requires expertise and methods from the basic sciences and bioethics, as well as constructive collaborations among autistic people, their parents, and autism researchers to anticipate early interventions that serve the community's interests and accommodate the varied experiences and preferences of people on the spectrum and their families. En ligne : http://dx.doi.org/10.1111/jcpp.13494 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1363-1373[article] Ethical dimensions of translational developmental neuroscience research in autism [Texte imprimé et/ou numérique] / A. MANZINI, Auteur ; E. J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; M. ELSABBAGH, Auteur ; M. H. JOHNSON, Auteur ; I. SINGH, Auteur . - p.1363-1373.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1363-1373
Mots-clés : Autism Spectrum Disorder/diagnosis/genetics Autistic Disorder Brain Child Early Intervention, Educational Humans Neurosciences Parents Autism biomarkers ethics genetics infant siblings neurodevelopment Ltd. and Servier and has received royalties from Sage Publications and Guilford Publications. Index. décimale : PER Périodiques Résumé : BACKGROUND: Since the 1990s, increasing research has been devoted to the identification of biomarkers for autism to help attain more objective diagnosis; enable early prediction of prognosis; and guide individualized intervention options. Early studies focused on the identification of genetic variants associated with autism, but more recently, research has expanded to investigate neurodevelopmental markers. While ethicists have extensively discussed issues around advances in autism genomics, much less ethical scrutiny has focused on research on early neurodevelopment and on the interventions being developed as a result. OBJECTIVES: We summarize the current state of the science on the identification of early markers for autism and its potential clinical applications, before providing an overview of the ethical issues arising from increasing understanding of children's neurodevelopment in very early life. RESULTS: Advances in the understanding of brain and behavioral trajectories preceding later autism diagnosis raise ethical concerns around three themes: (a) New models for understanding autism; (b) Risks and benefits of early identification and intervention; and (c) Communication of early concerns to families. These ethical issues should be further investigated in research conducted in partnership with autistic people and their families. CONCLUSIONS: This paper highlights the need for ethical scrutiny of early neurodevelopmental research in autism. Scrutiny requires expertise and methods from the basic sciences and bioethics, as well as constructive collaborations among autistic people, their parents, and autism researchers to anticipate early interventions that serve the community's interests and accommodate the varied experiences and preferences of people on the spectrum and their families. En ligne : http://dx.doi.org/10.1111/jcpp.13494 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456