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Quantitative autism traits in first degree relatives: evidence for the broader autism phenotype in fathers, but not in mothers and siblings / Wouter DE LA MARCHE in Autism, 16-3 (May 2012)
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Titre : Quantitative autism traits in first degree relatives: evidence for the broader autism phenotype in fathers, but not in mothers and siblings Type de document : Texte imprimé et/ou numérique Auteurs : Wouter DE LA MARCHE, Auteur ; Ilse L.J. NOENS, Auteur ; Jan LUTS, Auteur ; Evert M. SCHOLTE, Auteur ; Sabine VAN HUFFEL, Auteur ; Jean STEYAERT, Auteur Année de publication : 2012 Article en page(s) : p.247-260 Langues : Anglais (eng) Mots-clés : Quantitative autism traits broader autism phenotype autism spectrum disorders siblings parents Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) symptoms are present in unaffected relatives and individuals from the general population. Results are inconclusive, however, on whether unaffected relatives have higher levels of quantitative autism traits (QAT) or not. This might be due to differences in research populations, because behavioral data and molecular genetic research suggest that the genetic etiology of ASD is different in multiplex and simplex families. We compared 117 unaffected siblings and 276 parents of at least one child with ASD with 280 children and 595 adults from the general population on the presence of QAT using the Social Responsiveness Scale (SRS). Mean SRS scores for siblings, control children, parents and control adults were 25.4, 26.6, 33.7 and 32.9. Fathers of children with ASD showed significantly higher levels of QAT than controls, but siblings and mothers did not. We could not detect a statistically significant difference in SRS scores between relatives from simplex and multiplex families. These results do not support the theory of differential (genetic) etiology in multiplex and simplex families and suggest that a carried genetic risk is generally not expressed phenotypically in most relatives, except in fathers. En ligne : http://dx.doi.org/10.1177/1362361311421776 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Autism > 16-3 (May 2012) . - p.247-260[article] Quantitative autism traits in first degree relatives: evidence for the broader autism phenotype in fathers, but not in mothers and siblings [Texte imprimé et/ou numérique] / Wouter DE LA MARCHE, Auteur ; Ilse L.J. NOENS, Auteur ; Jan LUTS, Auteur ; Evert M. SCHOLTE, Auteur ; Sabine VAN HUFFEL, Auteur ; Jean STEYAERT, Auteur . - 2012 . - p.247-260.
Langues : Anglais (eng)
in Autism > 16-3 (May 2012) . - p.247-260
Mots-clés : Quantitative autism traits broader autism phenotype autism spectrum disorders siblings parents Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) symptoms are present in unaffected relatives and individuals from the general population. Results are inconclusive, however, on whether unaffected relatives have higher levels of quantitative autism traits (QAT) or not. This might be due to differences in research populations, because behavioral data and molecular genetic research suggest that the genetic etiology of ASD is different in multiplex and simplex families. We compared 117 unaffected siblings and 276 parents of at least one child with ASD with 280 children and 595 adults from the general population on the presence of QAT using the Social Responsiveness Scale (SRS). Mean SRS scores for siblings, control children, parents and control adults were 25.4, 26.6, 33.7 and 32.9. Fathers of children with ASD showed significantly higher levels of QAT than controls, but siblings and mothers did not. We could not detect a statistically significant difference in SRS scores between relatives from simplex and multiplex families. These results do not support the theory of differential (genetic) etiology in multiplex and simplex families and suggest that a carried genetic risk is generally not expressed phenotypically in most relatives, except in fathers. En ligne : http://dx.doi.org/10.1177/1362361311421776 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166