Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
3 recherche sur le mot-clé 'Translational research'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses / Zohreh TALEBIZADEH in Autism Research, 13-8 (August 2020)
[article]
Titre : The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses Type de document : Texte imprimé et/ou numérique Auteurs : Zohreh TALEBIZADEH, Auteur ; Ayten SHAH, Auteur Article en page(s) : p.1286-1299 Langues : Anglais (eng) Mots-clés : autism conceptual framework genetics engagement outcomes stakeholders translational research Index. décimale : PER Périodiques Résumé : The increasing emphasis on translational approaches to complex neuropsychiatric and neurodevelopmental conditions research requires scientists from a broad range of disciplines to build dynamic collaborations when formulating hypotheses and framing study designs. The need to integrate the knowledge and perspectives not only from multiple scientific silos but also from the populations impacted by these conditions presents a significant challenge to researchers, particularly for a heterogeneous condition like autism. As one path toward addressing these challenges, we have previously introduced Autism Genetics Outcomes (AutGO), an initiative to support broad stakeholder partnerships and promote a new integrated concept called GO (i.e., research approaches that draw on both genetics and clinical outcomes perspectives). Herein, we developed a workflow for collecting stakeholders' feedback toward the development of a GO hypothesis. AutGO is an evolving initiative, and here we describe how its three essential components (conceptual framework, applicability, and implementation) have been developed. As a proof-of-concept, the AutGO team sought to demonstrate how a GO hypothesis could be developed using a semi-structured literature review workflow. We also developed a prototype from published reports and formulated a GO hypothesis for autism. Rather than seeking community stakeholder input after a research project is conceptualized and designed, the developed conceptual framework demonstrates the feasibility of formulating scientific hypotheses by engaging stakeholders in retrospective semi-structured literature reviews. The presented workflow, prototype, and discussed recommendations will bring awareness in the autism research community about the benefits of applying the GO approach in order to promote translational aspects in genetics research. LAY SUMMARY: We used a community-based engagement approach to develop AutGO (Autism Genetics Outcomes), an initiative to establish stakeholder partnerships and to promote research approaches (we refer to as GO) that draw on both genetics and clinical outcomes perspectives. Specifically, we developed a conceptual framework that includes a literature review process for developing GO hypotheses and stakeholder feedback collection protocol. Our work will bring awareness in the autism research community about the benefits of integrating patient perspectives in genetics research. Autism Res 2020, 13: 1286-1299. © 2020 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2331 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Autism Research > 13-8 (August 2020) . - p.1286-1299[article] The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses [Texte imprimé et/ou numérique] / Zohreh TALEBIZADEH, Auteur ; Ayten SHAH, Auteur . - p.1286-1299.
Langues : Anglais (eng)
in Autism Research > 13-8 (August 2020) . - p.1286-1299
Mots-clés : autism conceptual framework genetics engagement outcomes stakeholders translational research Index. décimale : PER Périodiques Résumé : The increasing emphasis on translational approaches to complex neuropsychiatric and neurodevelopmental conditions research requires scientists from a broad range of disciplines to build dynamic collaborations when formulating hypotheses and framing study designs. The need to integrate the knowledge and perspectives not only from multiple scientific silos but also from the populations impacted by these conditions presents a significant challenge to researchers, particularly for a heterogeneous condition like autism. As one path toward addressing these challenges, we have previously introduced Autism Genetics Outcomes (AutGO), an initiative to support broad stakeholder partnerships and promote a new integrated concept called GO (i.e., research approaches that draw on both genetics and clinical outcomes perspectives). Herein, we developed a workflow for collecting stakeholders' feedback toward the development of a GO hypothesis. AutGO is an evolving initiative, and here we describe how its three essential components (conceptual framework, applicability, and implementation) have been developed. As a proof-of-concept, the AutGO team sought to demonstrate how a GO hypothesis could be developed using a semi-structured literature review workflow. We also developed a prototype from published reports and formulated a GO hypothesis for autism. Rather than seeking community stakeholder input after a research project is conceptualized and designed, the developed conceptual framework demonstrates the feasibility of formulating scientific hypotheses by engaging stakeholders in retrospective semi-structured literature reviews. The presented workflow, prototype, and discussed recommendations will bring awareness in the autism research community about the benefits of applying the GO approach in order to promote translational aspects in genetics research. LAY SUMMARY: We used a community-based engagement approach to develop AutGO (Autism Genetics Outcomes), an initiative to establish stakeholder partnerships and to promote research approaches (we refer to as GO) that draw on both genetics and clinical outcomes perspectives. Specifically, we developed a conceptual framework that includes a literature review process for developing GO hypotheses and stakeholder feedback collection protocol. Our work will bring awareness in the autism research community about the benefits of integrating patient perspectives in genetics research. Autism Res 2020, 13: 1286-1299. © 2020 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals LLC. En ligne : http://dx.doi.org/10.1002/aur.2331 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 A meta-analysis of self-management interventions for students with ASD / Lauren M. ZAESKE ; Elisabeth J. MALONE ; Kathleen N. ZIMMERMAN in Research in Autism Spectrum Disorders, 110 (February 2024)
[article]
Titre : A meta-analysis of self-management interventions for students with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. ZAESKE, Auteur ; Elisabeth J. MALONE, Auteur ; Kathleen N. ZIMMERMAN, Auteur Article en page(s) : p.102294 Mots-clés : Autism spectrum disorders Self-management interventions Self-monitoring Evidence-based practices Translational research Index. décimale : PER Périodiques Résumé : Background Self-management interventions (SMI) are a broad class of interventions used to teach students to assess, monitor, and adjust their own behavior without direct intervention from an educator. SMI support students with autism spectrum disorder (ASD) to learn valuable self-awareness and self-determination skills for better outcomes in adulthood. Methods A systematic review and meta-analysis were employed to examine the students with ASD who are likely to benefit from SMIs in educational settings, the conditions these interventions are effective under, and identify the discrete intervention packages, social validity, and anticipated effects of the intervention. Results This review examined 62 single case designs with adequate quality and rigor in 18 studies, including 34 cases and 53 students with ASD. Findings indicating limited participant and intervention condition reporting within the evidence-base. Conclusions Lack of translational reporting of ASD characteristics, implementation conditions, and training methods limited conclusions about for whom and under what conditions. Further, the majority of studies in the evidence base focused exclusively on self-monitoring interventions to address engagement behaviors, indicating a need for further examination of other self-management components. Future directions of translational research of SMI for students with ASD are discussed. En ligne : https://doi.org/10.1016/j.rasd.2023.102294 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520
in Research in Autism Spectrum Disorders > 110 (February 2024) . - p.102294[article] A meta-analysis of self-management interventions for students with ASD [Texte imprimé et/ou numérique] / Lauren M. ZAESKE, Auteur ; Elisabeth J. MALONE, Auteur ; Kathleen N. ZIMMERMAN, Auteur . - p.102294.
in Research in Autism Spectrum Disorders > 110 (February 2024) . - p.102294
Mots-clés : Autism spectrum disorders Self-management interventions Self-monitoring Evidence-based practices Translational research Index. décimale : PER Périodiques Résumé : Background Self-management interventions (SMI) are a broad class of interventions used to teach students to assess, monitor, and adjust their own behavior without direct intervention from an educator. SMI support students with autism spectrum disorder (ASD) to learn valuable self-awareness and self-determination skills for better outcomes in adulthood. Methods A systematic review and meta-analysis were employed to examine the students with ASD who are likely to benefit from SMIs in educational settings, the conditions these interventions are effective under, and identify the discrete intervention packages, social validity, and anticipated effects of the intervention. Results This review examined 62 single case designs with adequate quality and rigor in 18 studies, including 34 cases and 53 students with ASD. Findings indicating limited participant and intervention condition reporting within the evidence-base. Conclusions Lack of translational reporting of ASD characteristics, implementation conditions, and training methods limited conclusions about for whom and under what conditions. Further, the majority of studies in the evidence base focused exclusively on self-monitoring interventions to address engagement behaviors, indicating a need for further examination of other self-management components. Future directions of translational research of SMI for students with ASD are discussed. En ligne : https://doi.org/10.1016/j.rasd.2023.102294 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 Transforming the paradigm of child welfare / Catherine CERULLI in Development and Psychopathology, 33-2 (May 2021)
[article]
Titre : Transforming the paradigm of child welfare Type de document : Texte imprimé et/ou numérique Auteurs : Catherine CERULLI, Auteur ; Dante CICCHETTI, Auteur ; Elizabeth D. HANDLEY, Auteur ; Jody TODD MANLY, Auteur ; Fred A. ROGOSCH, Auteur ; Sheree L. TOTH, Auteur Année de publication : 2021 Article en page(s) : p.377-393 Langues : Anglais (eng) Mots-clés : abuse child maltreatment developmental psychopathology neglect translational research Index. décimale : PER Périodiques Résumé : As a founder of the field of applied developmental psychology, Dr Edward Zigler promoted public policy that translated scientific knowledge into real-world programs to improve the outcomes of high-risk children and families. Many researchers, practitioners, and public policy proponents have sought to carry on his legacy through integration of empirical research, evidence-based prevention and intervention, and advocacy to address a range of challenges facing families with young children. To advance the field of child maltreatment, a multidisciplinary team of investigators from the Universities of Rochester and Minnesota partnered with the Eunice Kennedy Shriver National Institute of Child Health and Human Development to create the Translational Research that Adapts New Science FOR Maltreatment Prevention Center (Transform). Building on state-of-the-art research methodologies and clinical practices, Transform leverages theoretically grounded research and evidence-based interventions to optimize outcomes for individuals across the life span who have experienced, or may be at risk for, maltreatment. Inspired by the work of Dr Zigler, Transform is committed to bridging science and real-world practice. Therefore, in addition to creating new science, Transform's Community Engagement Core provides translational science to a broad audience of investigators, child-serving professionals, and parental and governmental stakeholders. This article describes Transform's purpose, theoretical framework, current activities, and future directions. En ligne : http://dx.doi.org/10.1017/s0954579420002138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444
in Development and Psychopathology > 33-2 (May 2021) . - p.377-393[article] Transforming the paradigm of child welfare [Texte imprimé et/ou numérique] / Catherine CERULLI, Auteur ; Dante CICCHETTI, Auteur ; Elizabeth D. HANDLEY, Auteur ; Jody TODD MANLY, Auteur ; Fred A. ROGOSCH, Auteur ; Sheree L. TOTH, Auteur . - 2021 . - p.377-393.
Langues : Anglais (eng)
in Development and Psychopathology > 33-2 (May 2021) . - p.377-393
Mots-clés : abuse child maltreatment developmental psychopathology neglect translational research Index. décimale : PER Périodiques Résumé : As a founder of the field of applied developmental psychology, Dr Edward Zigler promoted public policy that translated scientific knowledge into real-world programs to improve the outcomes of high-risk children and families. Many researchers, practitioners, and public policy proponents have sought to carry on his legacy through integration of empirical research, evidence-based prevention and intervention, and advocacy to address a range of challenges facing families with young children. To advance the field of child maltreatment, a multidisciplinary team of investigators from the Universities of Rochester and Minnesota partnered with the Eunice Kennedy Shriver National Institute of Child Health and Human Development to create the Translational Research that Adapts New Science FOR Maltreatment Prevention Center (Transform). Building on state-of-the-art research methodologies and clinical practices, Transform leverages theoretically grounded research and evidence-based interventions to optimize outcomes for individuals across the life span who have experienced, or may be at risk for, maltreatment. Inspired by the work of Dr Zigler, Transform is committed to bridging science and real-world practice. Therefore, in addition to creating new science, Transform's Community Engagement Core provides translational science to a broad audience of investigators, child-serving professionals, and parental and governmental stakeholders. This article describes Transform's purpose, theoretical framework, current activities, and future directions. En ligne : http://dx.doi.org/10.1017/s0954579420002138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444