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Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder / Robert T. SCHULTZ in Autism - Open Access, 6-2 ([01/03/2016])
[article]
Titre : Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Robert T. SCHULTZ, Auteur ; Georgianna G. GOULD, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Autism Autism spectrum disorder Acetaminophen Anandamide Endocannabinoid Cannabinoid Fever Medication Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12-18months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08-33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs. non-ASD children use acetaminophen as a “first choice” compared to “never use” (OR 0.165, 95% CI 0.045, 0.599). We found significantly more children with ASD vs. non-ASD children change to the use of ibuprofen when acetaminophen is not effective at reducing fever (p = 0.033) and theorize this change in use is due to endocannabinoid system dysfunction. We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children. En ligne : https://dx.doi.org/10.4172/2165-7890.1000170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410
in Autism - Open Access > 6-2 [01/03/2016] . - 6 p.[article] Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Robert T. SCHULTZ, Auteur ; Georgianna G. GOULD, Auteur . - 6 p.
Langues : Anglais (eng)
in Autism - Open Access > 6-2 [01/03/2016] . - 6 p.
Mots-clés : Autism Autism spectrum disorder Acetaminophen Anandamide Endocannabinoid Cannabinoid Fever Medication Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12-18months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08-33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs. non-ASD children use acetaminophen as a “first choice” compared to “never use” (OR 0.165, 95% CI 0.045, 0.599). We found significantly more children with ASD vs. non-ASD children change to the use of ibuprofen when acetaminophen is not effective at reducing fever (p = 0.033) and theorize this change in use is due to endocannabinoid system dysfunction. We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children. En ligne : https://dx.doi.org/10.4172/2165-7890.1000170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study / Zeyan LIEW in Autism Research, 9-9 (September 2016)
[article]
Titre : Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Zeyan LIEW, Auteur ; Beate RITZ, Auteur ; Jasveer VIRK, Auteur ; Jørn OLSEN, Auteur Article en page(s) : p.951-958 Langues : Anglais (eng) Mots-clés : acetaminophen autism spectrum disorders infantile autism childhood behavior prenatal exposure pregnancy cohort Index. décimale : PER Périodiques Résumé : Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996–2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring. Information on acetaminophen use was collected prospectively from three computer-assisted telephone interviews. We used records from the Danish hospital and psychiatric registries to identify diagnoses of ASD. At the end of follow up, 1,027 (1.6%) children were diagnosed with ASD, 345 (0.5%) with infantile autism. We found that 31% of ASD (26% of infantile autism) have also been diagnosed with hyperkinetic disorders. More than 50% women reported ever using acetaminophen in pregnancy. We used Cox proportional hazards model to estimate hazard ratio (HR) and 95% confident interval (CI). Prenatal use of acetaminophen was associated with an increased risk of ASD accompanied by hyperkinetic symptoms (HR?=?1.51 95% CI 1.19–1.92), but not with other ASD cases (HR?=?1.06 95% CI 0.92–1.24). Longer duration of use (i.e., use for >20 weeks in gestation) increased the risk of ASD or infantile autism with hyperkinetic symptoms almost twofold. Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. Autism Res 2016, 9: 951–958. En ligne : http://dx.doi.org/10.1002/aur.1591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Autism Research > 9-9 (September 2016) . - p.951-958[article] Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study [Texte imprimé et/ou numérique] / Zeyan LIEW, Auteur ; Beate RITZ, Auteur ; Jasveer VIRK, Auteur ; Jørn OLSEN, Auteur . - p.951-958.
Langues : Anglais (eng)
in Autism Research > 9-9 (September 2016) . - p.951-958
Mots-clés : acetaminophen autism spectrum disorders infantile autism childhood behavior prenatal exposure pregnancy cohort Index. décimale : PER Périodiques Résumé : Acetaminophen (paracetamol) is the most commonly used pain and fever medication during pregnancy. Previously, a positive ecological correlation between acetaminophen use and autism spectrum disorders (ASD) has been reported but evidence from larger studies based on prospective data is lacking. We followed 64,322 children and mothers enrolled in the Danish National Birth Cohort (DNBC; 1996–2002) for average 12.7 years to investigate whether acetaminophen use in pregnancy is associated with increased risk of ASD in the offspring. Information on acetaminophen use was collected prospectively from three computer-assisted telephone interviews. We used records from the Danish hospital and psychiatric registries to identify diagnoses of ASD. At the end of follow up, 1,027 (1.6%) children were diagnosed with ASD, 345 (0.5%) with infantile autism. We found that 31% of ASD (26% of infantile autism) have also been diagnosed with hyperkinetic disorders. More than 50% women reported ever using acetaminophen in pregnancy. We used Cox proportional hazards model to estimate hazard ratio (HR) and 95% confident interval (CI). Prenatal use of acetaminophen was associated with an increased risk of ASD accompanied by hyperkinetic symptoms (HR?=?1.51 95% CI 1.19–1.92), but not with other ASD cases (HR?=?1.06 95% CI 0.92–1.24). Longer duration of use (i.e., use for >20 weeks in gestation) increased the risk of ASD or infantile autism with hyperkinetic symptoms almost twofold. Maternal use of acetaminophen in pregnancy was associated with ASD with hyperkinetic symptoms only, suggesting acetaminophen exposure early in fetal life may specifically impact this hyperactive behavioral phenotype. Autism Res 2016, 9: 951–958. En ligne : http://dx.doi.org/10.1002/aur.1591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294