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Lack of association between markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and autism in an Irish sample / Lynne E. COCHRANE in Autism Research, 3-6 (December 2010)
[article]
Titre : Lack of association between markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and autism in an Irish sample Type de document : Texte imprimé et/ou numérique Auteurs : Lynne E. COCHRANE, Auteur ; Katherine E. TANSEY, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur ; Richard ANNEY, Auteur Année de publication : 2010 Article en page(s) : p.342-344 Langues : Anglais (eng) Mots-clés : genetics allelic association Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder characterized by impairments in three core areas—language, social interaction and restricted/repetitive behaviours. It is generally accepted that genetics plays a large role in the aetiology of autism, but the exact mechanism is still unknown. We recently published evidence of an association between autism and the ITGA4 gene [Conroy et al., 2008]. Two genomic regions have shown evidence of linkage to autism in multiple studies— 2q31-q33 and 17q21-q22. Both of these regions harbour multiple integrin subunit genes. We tested markers in ITGA3, ITGA6, ITGAV and ITGB3 for association with autism in the Irish autism sample. No markers in ITGA3, ITGA6, ITGAV and ITGB3 were found to be associated with autism. Three 3-marker haplotypes in ITGAV, ITGA3 and ITGA6 were found to be nominally associated (0.01 En ligne : http://dx.doi.org/10.1002/aur.157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-6 (December 2010) . - p.342-344[article] Lack of association between markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and autism in an Irish sample [Texte imprimé et/ou numérique] / Lynne E. COCHRANE, Auteur ; Katherine E. TANSEY, Auteur ; Michael GILL, Auteur ; Louise GALLAGHER, Auteur ; Richard ANNEY, Auteur . - 2010 . - p.342-344.
Langues : Anglais (eng)
in Autism Research > 3-6 (December 2010) . - p.342-344
Mots-clés : genetics allelic association Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder characterized by impairments in three core areas—language, social interaction and restricted/repetitive behaviours. It is generally accepted that genetics plays a large role in the aetiology of autism, but the exact mechanism is still unknown. We recently published evidence of an association between autism and the ITGA4 gene [Conroy et al., 2008]. Two genomic regions have shown evidence of linkage to autism in multiple studies— 2q31-q33 and 17q21-q22. Both of these regions harbour multiple integrin subunit genes. We tested markers in ITGA3, ITGA6, ITGAV and ITGB3 for association with autism in the Irish autism sample. No markers in ITGA3, ITGA6, ITGAV and ITGB3 were found to be associated with autism. Three 3-marker haplotypes in ITGAV, ITGA3 and ITGA6 were found to be nominally associated (0.01 En ligne : http://dx.doi.org/10.1002/aur.157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115