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Does the cognitive architecture of simplex and multiplex ASD families differ? / Anoek M. OERLEMANS in Journal of Autism and Developmental Disorders, 46-2 (February 2016)
[article]
Titre : Does the cognitive architecture of simplex and multiplex ASD families differ? Type de document : Texte imprimé et/ou numérique Auteurs : Anoek M. OERLEMANS, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur Année de publication : 2016 Article en page(s) : p.489-501 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder (ASD) Simplex-multiplex stratification Family Unaffected siblings Cognition Index. décimale : PER Périodiques Résumé : Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2572-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.489-501[article] Does the cognitive architecture of simplex and multiplex ASD families differ? [Texte imprimé et/ou numérique] / Anoek M. OERLEMANS, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur . - 2016 . - p.489-501.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-2 (February 2016) . - p.489-501
Mots-clés : Autism Spectrum Disorder (ASD) Simplex-multiplex stratification Family Unaffected siblings Cognition Index. décimale : PER Périodiques Résumé : Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2572-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=280 Neurocognitive markers of late-onset ADHD: a 6-year longitudinal study / Shahrzad ILBEGI in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)
[article]
Titre : Neurocognitive markers of late-onset ADHD: a 6-year longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Shahrzad ILBEGI, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Stephen V. FARAONE, Auteur ; Jaap OOSTERLAAN, Auteur ; Marjolein LUMAN, Auteur ; Marloes VAN LIESHOUT, Auteur ; Nanda N. ROMMELSE, Auteur Année de publication : 2021 Article en page(s) : p.244-252 Langues : Anglais (eng) Mots-clés : Late-onset ADHD neurocognitive markers unaffected siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: There is an increased interest in 'late-onset' attention-deficit/hyperactivity disorder (ADHD), referring to the onset of clinically significant ADHD symptoms after the age of 12 years. This study aimed to examine whether unaffected siblings with late-onset ADHD could be differentiated from stable unaffected siblings by their neurocognitive functioning in childhood. METHODS: We report findings from a 6-year prospective, longitudinal study of the Dutch part of the International Multicenter ADHD Genetics (IMAGE) study, including individuals with childhood-onset (persistent) ADHD (n = 193), their siblings with late-onset ADHD (n = 34), their stable unaffected siblings (n = 111) and healthy controls (n = 186). At study entry (mean age: 11.3) and follow-up (mean age: 17.01), participants were assessed for ADHD by structured psychiatric interviews and multi-informant questionnaires. Several neurocognitive functions were assessed at baseline and after 6 years, including time reproduction, timing variability (reaction time variability and time production variability), reaction time speed, motor control and working memory; intelligence was taken as a measure of overall neurocognitive functioning. RESULTS: Siblings with late-onset ADHD were similar to individuals with childhood-onset ADHD in showing longer reaction times and/or higher error rates on all neurocognitive measures at baseline and follow-up, when compared to healthy controls. They differed from stable unaffected siblings (who were similar to healthy controls) by greater reaction time variability and timing production variability at baseline. No significant group by time interaction was found for any of the tasks. CONCLUSIONS: For unaffected siblings of individuals with ADHD, reaction time variability and timing production variability may serve as neurocognitive marker for late-onset ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13272 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440
in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.244-252[article] Neurocognitive markers of late-onset ADHD: a 6-year longitudinal study [Texte imprimé et/ou numérique] / Shahrzad ILBEGI, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur ; Barbara FRANKE, Auteur ; Stephen V. FARAONE, Auteur ; Jaap OOSTERLAAN, Auteur ; Marjolein LUMAN, Auteur ; Marloes VAN LIESHOUT, Auteur ; Nanda N. ROMMELSE, Auteur . - 2021 . - p.244-252.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-2 (February 2021) . - p.244-252
Mots-clés : Late-onset ADHD neurocognitive markers unaffected siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: There is an increased interest in 'late-onset' attention-deficit/hyperactivity disorder (ADHD), referring to the onset of clinically significant ADHD symptoms after the age of 12 years. This study aimed to examine whether unaffected siblings with late-onset ADHD could be differentiated from stable unaffected siblings by their neurocognitive functioning in childhood. METHODS: We report findings from a 6-year prospective, longitudinal study of the Dutch part of the International Multicenter ADHD Genetics (IMAGE) study, including individuals with childhood-onset (persistent) ADHD (n = 193), their siblings with late-onset ADHD (n = 34), their stable unaffected siblings (n = 111) and healthy controls (n = 186). At study entry (mean age: 11.3) and follow-up (mean age: 17.01), participants were assessed for ADHD by structured psychiatric interviews and multi-informant questionnaires. Several neurocognitive functions were assessed at baseline and after 6 years, including time reproduction, timing variability (reaction time variability and time production variability), reaction time speed, motor control and working memory; intelligence was taken as a measure of overall neurocognitive functioning. RESULTS: Siblings with late-onset ADHD were similar to individuals with childhood-onset ADHD in showing longer reaction times and/or higher error rates on all neurocognitive measures at baseline and follow-up, when compared to healthy controls. They differed from stable unaffected siblings (who were similar to healthy controls) by greater reaction time variability and timing production variability at baseline. No significant group by time interaction was found for any of the tasks. CONCLUSIONS: For unaffected siblings of individuals with ADHD, reaction time variability and timing production variability may serve as neurocognitive marker for late-onset ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13272 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440