Article: texte impriméCandidate Electrophysiological Endophenotypes of Hyper-Reactivity to Change in Autism / Marie GOMOT in Journal of Autism and Developmental Disorders, 41-6 (June 2011) Ouvrir le lien
[article] 
in Journal of Autism and Developmental Disorders > 41-6 (June 2011) . - p.705-714
Titre :Candidate Electrophysiological Endophenotypes of Hyper-Reactivity to Change in Autism
Type de document : texte imprimé
Auteurs : Marie GOMOT, Auteur ; Romuald BLANC, Auteur ; Helen CLERY, Auteur ; Sylvie ROUX, Auteur ; Catherine BARTHELEMY, Auteur ; Nicole BRUNEAU, Auteur
Année de publication : 2011
Article en page(s) : p.705-714
Langues :Anglais (eng)
Mots-clés : Autism  Change processing  Auditory evoked potential (AEP)  Mismatch negativity (MMN)  P3a  Children
Index. décimale : PER Périodiques
Résumé : Although resistance to change is a main feature of autism, the brain processes underlying this aspect of the disorder remain poorly understood. The aims of this study were to examine neural basis of auditory change-detection in children with autism spectrum disorders (ASD; N = 27) through electrophysiological patterns (MMN, P3a) and to test whether these are quantitatively related to intolerance of change (using the BSE-R scale). ASD displayed significantly shorter MMN latency and larger P3a than controls, indicating a greater tendency to switch attention to deviant events. These electrophysiological abnormalities were significantly more marked in children who displayed greater difficulties in tolerating change. The atypical neurophysiological mechanism of change perception identified might thus be associated with one of the hallmark behavioural manifestations of autism.
En ligne : http://dx.doi.org/10.1007/s10803-010-1091-y
Permalink :http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1273

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