Article: texte impriméThe dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction / Marieke E. ALTINK in Journal of Child Psychology and Psychiatry, 49-10 (October 2008) Ouvrir le lien
[article] 
in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1053-1060
Titre :The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction
Type de document : texte imprimé
Auteurs : Marieke E. ALTINK, Auteur ; Joseph A. SERGEANT, Auteur ; Wai CHEN, Auteur ; Keeley-Joanne BROOKES, Auteur ; Richard ANNEY, Auteur ; Ellen A. FLIERS, Auteur ; Dorine I.E. SLAATS–WILLEMSE, Auteur ; Barbara FRANKE, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Margaret J. THOMPSON, Auteur ; Michael GILL, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Nanda N.J. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Edmund J.S. SONUGA-BARKE, Auteur ; Aisling MULLIGAN, Auteur
Article en page(s) : p.1053-1060
Langues :Anglais (eng)
Mots-clés : Dopamine-receptor-D4-gene attention-deficit-hyperactivity-disorder-(ADHD) maternal-smoking-during-pregnancy gene-by-environment-interaction
Index. décimale : PER Périodiques
Résumé : Background: The dopamine receptor D4 (DRD4) 7-repeat allele and maternal smoking during pregnancy are both considered as risk factors in the aetiology of attention deficit hyperactivity disorder (ADHD), but few studies have been conducted on their interactive effects in causing ADHD. The purpose of this study is to examine the gene by environment (G×E) interaction of the DRD4 7-repeat allele and smoking during pregnancy on ADHD and oppositional behavior in families from the International Multicenter ADHD Genetics project; and further, to test the hypothesis that the direction of effect of the DRD4 7-repeat allele differs between ADHD affected and unaffected children.

Methods: Linear mixed models were used to assess main and interactive effects of the DRD4 7-repeat allele and smoking during pregnancy in 539 ADHD-affected children and their 407 unaffected siblings, aged 6–17 years.

Results: There was some evidence pointing to differential effects of the DRD4 7-repeat allele on ADHD and oppositional symptoms in the affected (fewer symptoms) and unaffected children (increasing ADHD symptoms of teacher ratings). Affected children were more often exposed to prenatal smoking than unaffected children. There were limited main effects of prenatal smoking on severity of symptoms. Given the number of tests performed, no indication was found for G×E interactions.

Conclusion: Despite the large sample size, no G×E interactions were found. The impact of the DRD4 7-repeat allele might differ, depending on affected status and rater. This finding is discussed in terms of differences in the activity of the dopaminergic system and of different genes involved in rater-specific behaviors.
En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01998.x
Permalink :http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=6069

Centre d'Information et de Documentation
du CRA Rhône-Alpes

Accueil

Se connecter



Mot de passe oublié ?

Météo

la météo à BRON

Adresse

Centre d'Information et de Documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier, bât.211
95, Bd Pinel
F-69677 BRON
Horaires :
Lundi au Vendredi :
9h00 12h30 - 13h30 17h00
 
Tél:+33(0)4 37 91 54 65
Fax: +33(0)4 37 91 54 37
contact