A preliminary study of gene polymorphisms involved in the neurotransmitters metabolism of a homogeneous Spanish autistic group / Fernando CALAHORRO in Research in Autism Spectrum Disorders, 3-2 (April-june 2009)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 3-2 (April-june 2009) . - p.438-443 Titre : A preliminary study of gene polymorphisms involved in the neurotransmitters metabolism of a homogeneous Spanish autistic group Type de document : Texte imprimé et/ou numérique Auteurs : Fernando CALAHORRO, Auteur ; Vicente SANCHEZ, Auteur ; Eudoxia GAY, Auteur ; Rafael BURGOS, Auteur ; Pilar TIENDA, Auteur ; Auxiliadora ROMERO, Auteur ; Yolanza SANZ, Auteur ; Teresa GUIJARRO, Auteur ; Nuria ANAYA, Auteur ; Encarna ALEJANDRE, Auteur ; Manuel RUIZ-RUBIO, Auteur Année de publication : 2009 Article en page(s) : p.438-443 Langues : Anglais (eng) Mots-clés : Autism DAT1 Dopamine DRD4 MAO-A Serotonin SLC6A4 Index. décimale : PER Périodiques Résumé : Twin studies have shown a strong genetic component for autism. Neurotransmitters, such as serotonin and catecholamines, have been suggested to play a role in the disease since they have an essential function in synaptogenesis and brain development. In this preliminary study, polymorphism of genes implicated in the serotonergic and dopaminergic pathways have been examined in a Spanish population of children diagnosed with autism. Significant association with the disorder was found for the short allele in the promoter of the gene encoding the serotonin transporter (SLC6A4); in addition, a preferential maternal transmission of this allele to affected offspring was observed. En ligne : http://dx.doi.org/10.1016/j.rasd.2008.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=709 [article] A preliminary study of gene polymorphisms involved in the neurotransmitters metabolism of a homogeneous Spanish autistic group [Texte imprimé et/ou numérique] / Fernando CALAHORRO, Auteur ; Vicente SANCHEZ, Auteur ; Eudoxia GAY, Auteur ; Rafael BURGOS, Auteur ; Pilar TIENDA, Auteur ; Auxiliadora ROMERO, Auteur ; Yolanza SANZ, Auteur ; Teresa GUIJARRO, Auteur ; Nuria ANAYA, Auteur ; Encarna ALEJANDRE, Auteur ; Manuel RUIZ-RUBIO, Auteur . - 2009 . - p.438-443. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 3-2 (April-june 2009) . - p.438-443 Mots-clés : Autism DAT1 Dopamine DRD4 MAO-A Serotonin SLC6A4 Index. décimale : PER Périodiques Résumé : Twin studies have shown a strong genetic component for autism. Neurotransmitters, such as serotonin and catecholamines, have been suggested to play a role in the disease since they have an essential function in synaptogenesis and brain development. In this preliminary study, polymorphism of genes implicated in the serotonergic and dopaminergic pathways have been examined in a Spanish population of children diagnosed with autism. Significant association with the disorder was found for the short allele in the promoter of the gene encoding the serotonin transporter (SLC6A4); in addition, a preferential maternal transmission of this allele to affected offspring was observed. En ligne : http://dx.doi.org/10.1016/j.rasd.2008.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=709

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