Language performance in siblings of nonverbal children with autism / Yonata LEVY in Autism, 15-3 (May 2011)  

Public ISBD [article]  inAutism > 15-3 (May 2011) . - p.341-354 Titre : Language performance in siblings of nonverbal children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Yonata LEVY, Auteur ; Chanit BAR-YUDA, Auteur Année de publication : 2011 Article en page(s) : p.341-354 Langues : Anglais (eng) Mots-clés : IQ  language  nonverbal autism  siblings Index. décimale : PER Périodiques Résumé : The study focuses on language and cognitive abilities of siblings of the linguistically most affected children with autism (i.e. siblings of nonverbal children — SIBS-ANV). Twenty-eight SIBS-ANV (17 boys), ages 4—9 years, took part in the study. All children attended regular schools, and none had received a diagnosis of autism. Controls were 27 typically developing children (SIBS-TD; 16 boys) matched to the SIBS-ANV on age, family background, socioeconomic status and type of school they attended. Significant IQ differences, as well as language differences as measured on the Clinical Evaluation of Language Fundamentals (CELF), emerged between SIBS-ANV and SIBS-TD. However, differences in the language scores mostly disappeared when PIQ and FSIQ were controlled for. Furthermore, grammatical analysis of spontaneous speech samples produced in the course of testing did not reveal any significant differences between the groups. These results add to recent work suggesting that language deficits may not be part of the Broad Autism Phenotype (BAP). It further suggests that the cognitive deficit characteristic of nonverbal people with autism may be familial. En ligne : http://dx.doi.org/10.1177/1362361310386504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 [article] Language performance in siblings of nonverbal children with autism [Texte imprimé et/ou numérique] / Yonata LEVY, Auteur ; Chanit BAR-YUDA, Auteur . - 2011 . - p.341-354. Langues : Anglais (eng) in Autism > 15-3 (May 2011) . - p.341-354 Mots-clés : IQ  language  nonverbal autism  siblings Index. décimale : PER Périodiques Résumé : The study focuses on language and cognitive abilities of siblings of the linguistically most affected children with autism (i.e. siblings of nonverbal children — SIBS-ANV). Twenty-eight SIBS-ANV (17 boys), ages 4—9 years, took part in the study. All children attended regular schools, and none had received a diagnosis of autism. Controls were 27 typically developing children (SIBS-TD; 16 boys) matched to the SIBS-ANV on age, family background, socioeconomic status and type of school they attended. Significant IQ differences, as well as language differences as measured on the Clinical Evaluation of Language Fundamentals (CELF), emerged between SIBS-ANV and SIBS-TD. However, differences in the language scores mostly disappeared when PIQ and FSIQ were controlled for. Furthermore, grammatical analysis of spontaneous speech samples produced in the course of testing did not reveal any significant differences between the groups. These results add to recent work suggesting that language deficits may not be part of the Broad Autism Phenotype (BAP). It further suggests that the cognitive deficit characteristic of nonverbal people with autism may be familial. En ligne : http://dx.doi.org/10.1177/1362361310386504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130

Research Review: Crossing syndrome boundaries in the search for brain endophenotypes / Yonata LEVY in Journal of Child Psychology and Psychiatry, 50-6 (June 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-6 (June 2009) . - p.657-668 Titre : Research Review: Crossing syndrome boundaries in the search for brain endophenotypes Type de document : Texte imprimé et/ou numérique Auteurs : Yonata LEVY, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2009 Article en page(s) : p.657-668 Langues : Anglais (eng) Mots-clés : Syndrome trait behavior brain-imaging genetic Index. décimale : PER Périodiques Résumé : The inherent imprecision of behavioral phenotyping is the single most important factor contributing to the failure to discover the biological factors that are involved in psychiatric and neurodevelopmental disorders (e.g., Bearden & Freimer, 2006). In this review article we argue that in addition to an appreciation of the inherent complexity at the biological level, a rather urgent task facing behavioral scientists involves a reconsideration of the role that clinical syndromes play in psychological theorizing, as well as in research into the biological basis of cognition and personality. Syndrome heterogeneity, cross-syndrome similarities and syndrome comorbidities question the relevance of syndromes to biological research. It is suggested that the search for brain endophenotypes, intermediate between genes and behavior, should be based on cross-syndrome, trait classification. Cohort selection should rest on behavioral homogeneity, enabling, when necessary, syndrome heterogeneity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01986.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=755 [article] Research Review: Crossing syndrome boundaries in the search for brain endophenotypes [Texte imprimé et/ou numérique] / Yonata LEVY, Auteur ; Richard P. EBSTEIN, Auteur . - 2009 . - p.657-668. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-6 (June 2009) . - p.657-668 Mots-clés : Syndrome trait behavior brain-imaging genetic Index. décimale : PER Périodiques Résumé : The inherent imprecision of behavioral phenotyping is the single most important factor contributing to the failure to discover the biological factors that are involved in psychiatric and neurodevelopmental disorders (e.g., Bearden & Freimer, 2006). In this review article we argue that in addition to an appreciation of the inherent complexity at the biological level, a rather urgent task facing behavioral scientists involves a reconsideration of the role that clinical syndromes play in psychological theorizing, as well as in research into the biological basis of cognition and personality. Syndrome heterogeneity, cross-syndrome similarities and syndrome comorbidities question the relevance of syndromes to biological research. It is suggested that the search for brain endophenotypes, intermediate between genes and behavior, should be based on cross-syndrome, trait classification. Cohort selection should rest on behavioral homogeneity, enabling, when necessary, syndrome heterogeneity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01986.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=755

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