Children's Attentional Biases and 5-HTTLPR Genotype: Potential Mechanisms Linking Mother and Child Depression / Brandon E. GIBB in Journal of Clinical Child & Adolescent Psychology, 38-3 (May 2009)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 38-3 (May 2009) . - p.415-426 Titre : Children's Attentional Biases and 5-HTTLPR Genotype: Potential Mechanisms Linking Mother and Child Depression Type de document : Texte imprimé et/ou numérique Auteurs : Brandon E. GIBB, Auteur ; Jessica S. BENAS, Auteur ; Marie GRASSIA, Auteur ; John E. MCGEARY, Auteur Année de publication : 2009 Article en page(s) : p.415-426 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In this study, we examined the roles of specific cognitive (attentional bias) and genetic (5-HTTLPR) risk factors in the intergenerational transmission of depression. Focusing first on the link between maternal history of major depressive disorder (MDD) and children's attentional biases, we found that children of mothers with a history of MDD during their children's lives, compared to children of mothers with no depression history, exhibited greater attentional avoidance of sad faces. This attention bias was specific to sad, rather than happy or angry, faces. There was also preliminary evidence that this relation is stronger among children carrying the 5-HTTLPR S or LG allele than among those homozygous for the LA allele. Next, conceptualizing mothers' levels of depressive symptoms during the multi-wave prospective follow-up within a vulnerability-stress framework, we found evidence for a three-way child 5-HTTLPR attentional bias mother depressive symptom interaction predicting children's depressive symptoms. Specifically, the relation between mother and child depressive symptom levels over time was strongest among children carrying the 5-HTTLR S or LG allele who also exhibited attentional avoidance of sad faces. These findings provide initial support for role of children's 5-HTTLPR genotype and attentional biases for sad faces in the intergenerational transmission of depression. En ligne : http://dx.doi.org/10.1080/15374410902851705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=757 [article] Children's Attentional Biases and 5-HTTLPR Genotype: Potential Mechanisms Linking Mother and Child Depression [Texte imprimé et/ou numérique] / Brandon E. GIBB, Auteur ; Jessica S. BENAS, Auteur ; Marie GRASSIA, Auteur ; John E. MCGEARY, Auteur . - 2009 . - p.415-426. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 38-3 (May 2009) . - p.415-426 Index. décimale : PER Périodiques Résumé : In this study, we examined the roles of specific cognitive (attentional bias) and genetic (5-HTTLPR) risk factors in the intergenerational transmission of depression. Focusing first on the link between maternal history of major depressive disorder (MDD) and children's attentional biases, we found that children of mothers with a history of MDD during their children's lives, compared to children of mothers with no depression history, exhibited greater attentional avoidance of sad faces. This attention bias was specific to sad, rather than happy or angry, faces. There was also preliminary evidence that this relation is stronger among children carrying the 5-HTTLPR S or LG allele than among those homozygous for the LA allele. Next, conceptualizing mothers' levels of depressive symptoms during the multi-wave prospective follow-up within a vulnerability-stress framework, we found evidence for a three-way child 5-HTTLPR attentional bias mother depressive symptom interaction predicting children's depressive symptoms. Specifically, the relation between mother and child depressive symptom levels over time was strongest among children carrying the 5-HTTLR S or LG allele who also exhibited attentional avoidance of sad faces. These findings provide initial support for role of children's 5-HTTLPR genotype and attentional biases for sad faces in the intergenerational transmission of depression. En ligne : http://dx.doi.org/10.1080/15374410902851705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=757

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