Peripherally administered IL-1α interferes with scopolamine-induced amnesia in mice / Mauro BIANCHI in Cognitive Brain Research, 1-4 (December 1993)

Public ISBD [article]  inCognitive Brain Research > 1-4 (December 1993) . - p.257-259 Titre : Peripherally administered IL-1α interferes with scopolamine-induced amnesia in mice Type de document : Texte imprimé et/ou numérique Auteurs : Mauro BIANCHI, Auteur ; Alberto E. PANERAI, Auteur Année de publication : 1993 Article en page(s) : p.257-259 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We studied the effects of human recombinant interleukin-1α on scopolamine-induced amnesia for a passive avoidance response in the mouse. Post-training intraperitoneal administration of the cytokine (0.25 or 0.50 μg/mouse) significantly reduced the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results indicate that peripheral interleukin-1α can influence behavior and suggest the involvement of the cholinergic system in the neuromodulatory actions of this cytokine. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782 [article] Peripherally administered IL-1α interferes with scopolamine-induced amnesia in mice [Texte imprimé et/ou numérique] / Mauro BIANCHI, Auteur ; Alberto E. PANERAI, Auteur . - 1993 . - p.257-259. Langues : Anglais (eng) in Cognitive Brain Research > 1-4 (December 1993) . - p.257-259 Index. décimale : PER Périodiques Résumé : We studied the effects of human recombinant interleukin-1α on scopolamine-induced amnesia for a passive avoidance response in the mouse. Post-training intraperitoneal administration of the cytokine (0.25 or 0.50 μg/mouse) significantly reduced the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results indicate that peripheral interleukin-1α can influence behavior and suggest the involvement of the cholinergic system in the neuromodulatory actions of this cytokine. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=782

Reversal of scopolamine-induced amnesia by the GABAB receptor antagonist CGP 35348 in the mouse / Mauro BIANCHI in Cognitive Brain Research, 1-2 (April 1993)

Public ISBD [article]  inCognitive Brain Research > 1-2 (April 1993) . - p.135-136 Titre : Reversal of scopolamine-induced amnesia by the GABAB receptor antagonist CGP 35348 in the mouse Type de document : Texte imprimé et/ou numérique Auteurs : Mauro BIANCHI, Auteur ; Alberto E. PANERAI, Auteur Année de publication : 1993 Article en page(s) : p.135-136 Langues : Anglais (eng) Mots-clés : GABA-B-receptor CGP-35348 Memory Passive-avoidance Scopolamine-induced-amnesia Index. décimale : PER Périodiques Résumé : We studied the effects of CGP 35348, a centrally active blocker of GABAB receptors, on scopolamine-induced amnesia for a passive avoidance response in the mouse. Both pre-training or post-training intraperitoneal administration of the GABAB antagonist (75, 150 and 300 mg/kg i.p.) significantly reduces the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results are in agreement with previous observations indicating a role for the GABAB receptors in the modulation of memory function, and suggest a possible role of GABAB receptor antagonists as nootropic drugs. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781 [article] Reversal of scopolamine-induced amnesia by the GABAB receptor antagonist CGP 35348 in the mouse [Texte imprimé et/ou numérique] / Mauro BIANCHI, Auteur ; Alberto E. PANERAI, Auteur . - 1993 . - p.135-136. Langues : Anglais (eng) in Cognitive Brain Research > 1-2 (April 1993) . - p.135-136 Mots-clés : GABA-B-receptor CGP-35348 Memory Passive-avoidance Scopolamine-induced-amnesia Index. décimale : PER Périodiques Résumé : We studied the effects of CGP 35348, a centrally active blocker of GABAB receptors, on scopolamine-induced amnesia for a passive avoidance response in the mouse. Both pre-training or post-training intraperitoneal administration of the GABAB antagonist (75, 150 and 300 mg/kg i.p.) significantly reduces the amnesic effect of scopolamine (1.0 mg/kg i.p.). Our results are in agreement with previous observations indicating a role for the GABAB receptors in the modulation of memory function, and suggest a possible role of GABAB receptor antagonists as nootropic drugs. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=781

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