Genetic and environmental influence on attachment disorganization / Gottfried SPANGLER in Journal of Child Psychology and Psychiatry, 50-8 (August 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.952-961 Titre : Genetic and environmental influence on attachment disorganization Type de document : Texte imprimé et/ou numérique Auteurs : Gottfried SPANGLER, Auteur ; Monika JOHANN, Auteur ; Zsolt RONAI, Auteur ; Peter ZIMMERMANN, Auteur Année de publication : 2009 Article en page(s) : p.952-961 Langues : Anglais (eng) Mots-clés : Attachment gene–environment-interaction DRD4 serotonin-transporter Index. décimale : PER Périodiques Résumé : Background: Empirical studies demonstrate that maternal sensitivity is associated with attachment security in infancy, while maternal frightening/frightened behavior is related to attachment disorganization. However, attachment disorganization is also predicted by individual dispositions in infancy. Indeed, recent studies indicate a link between attachment disorganization and DRD4 gene polymorphisms, thus suggesting a genetic vulnerability for attachment disorganization. The aims of our study were twofold, to test a) a possible direct link between molecular genetic variations and attachment disorganization, and b) a possible gene–environment interaction with a moderating effect of early maternal caregiving. Methods: Attachment security and disorganization, as well as quality of maternal behavior were assessed in the infants of the Regensburg Longitudinal Study IV (N = 106) at the age of 12 months. DNA samples were collected in order to assess the exon III repeat polymorphism in the coding region and the −521 C/T single nucleotide polymorphism (SNP) in the regulatory region of the DRD4 gene and a repeat polymorphism (5-HTTLPR) in the promoter region of the serotonin transporter gene. Results: Significant associations were found between attachment disorganization and the short polymorphism of the serotonin transporter gene. Also, a gene–environment interaction indicated that this genetic association was only valid for infants of mothers exhibiting low responsiveness. No other significant genetic associations with attachment disorganization were apparent. Conclusions: The study suggests a gene–environment interaction whereby biological determinants of attachment disorganization are moderated by social experiences. Different pathways of the development of attachment disorganization are discussed based on a bio-behavioral model of development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02054.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=787 [article] Genetic and environmental influence on attachment disorganization [Texte imprimé et/ou numérique] / Gottfried SPANGLER, Auteur ; Monika JOHANN, Auteur ; Zsolt RONAI, Auteur ; Peter ZIMMERMANN, Auteur . - 2009 . - p.952-961. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.952-961 Mots-clés : Attachment gene–environment-interaction DRD4 serotonin-transporter Index. décimale : PER Périodiques Résumé : Background: Empirical studies demonstrate that maternal sensitivity is associated with attachment security in infancy, while maternal frightening/frightened behavior is related to attachment disorganization. However, attachment disorganization is also predicted by individual dispositions in infancy. Indeed, recent studies indicate a link between attachment disorganization and DRD4 gene polymorphisms, thus suggesting a genetic vulnerability for attachment disorganization. The aims of our study were twofold, to test a) a possible direct link between molecular genetic variations and attachment disorganization, and b) a possible gene–environment interaction with a moderating effect of early maternal caregiving. Methods: Attachment security and disorganization, as well as quality of maternal behavior were assessed in the infants of the Regensburg Longitudinal Study IV (N = 106) at the age of 12 months. DNA samples were collected in order to assess the exon III repeat polymorphism in the coding region and the −521 C/T single nucleotide polymorphism (SNP) in the regulatory region of the DRD4 gene and a repeat polymorphism (5-HTTLPR) in the promoter region of the serotonin transporter gene. Results: Significant associations were found between attachment disorganization and the short polymorphism of the serotonin transporter gene. Also, a gene–environment interaction indicated that this genetic association was only valid for infants of mothers exhibiting low responsiveness. No other significant genetic associations with attachment disorganization were apparent. Conclusions: The study suggests a gene–environment interaction whereby biological determinants of attachment disorganization are moderated by social experiences. Different pathways of the development of attachment disorganization are discussed based on a bio-behavioral model of development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02054.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=787

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