Impaired spatial navigation in pediatric anxiety / Sven C. MUELLER in Journal of Child Psychology and Psychiatry, 50-10 (October 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-10 (October 2009) . - p.1227-1234 Titre : Impaired spatial navigation in pediatric anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Sven C. MUELLER, Auteur ; Daniel Samuel PINE, Auteur ; Monique ERNST, Auteur ; Veronica TEMPLE, Auteur ; Brian CORNWELL, Auteur ; Christian GRILLON, Auteur Année de publication : 2009 Article en page(s) : p.1227-1234 Langues : Anglais (eng) Mots-clés : Pediatric anxiety hippocampus water-maze spatial-navigation Index. décimale : PER Périodiques Résumé : Background: Previous theories implicate hippocampal dysfunction in anxiety disorders. Most of the data supporting these theories stem from animal research, particularly lesion studies. The generalization of findings from rodent models to human function is hampered by fundamental inter-species differences. The present work uses a task of spatial orientation, which is known to rely on hippocampal function. Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders. Methods: Thirty-four treatment-naive children with an anxiety disorder (mean 11.00 years ± 2.54) are compared to 35 healthy age- and IQ-matched healthy children (mean 11.95 years ± 2.36) on a virtual, computer-based equivalent of the Morris Water Maze task. Results: Results indicate that children with anxiety disorder exhibit overall impaired performance relative to the comparison group. Anxious children made more heading direction errors and had worse accuracy in completing trials relative to controls. Conclusions: The results present novel evidence that spatial orientation deficits occur in pediatric anxiety. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02112.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=838 [article] Impaired spatial navigation in pediatric anxiety [Texte imprimé et/ou numérique] / Sven C. MUELLER, Auteur ; Daniel Samuel PINE, Auteur ; Monique ERNST, Auteur ; Veronica TEMPLE, Auteur ; Brian CORNWELL, Auteur ; Christian GRILLON, Auteur . - 2009 . - p.1227-1234. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-10 (October 2009) . - p.1227-1234 Mots-clés : Pediatric anxiety hippocampus water-maze spatial-navigation Index. décimale : PER Périodiques Résumé : Background: Previous theories implicate hippocampal dysfunction in anxiety disorders. Most of the data supporting these theories stem from animal research, particularly lesion studies. The generalization of findings from rodent models to human function is hampered by fundamental inter-species differences. The present work uses a task of spatial orientation, which is known to rely on hippocampal function. Deficits in spatial navigation in anxious children suggest that the hippocampal network involved in spatial orientation is also implicated in anxiety disorders. Methods: Thirty-four treatment-naive children with an anxiety disorder (mean 11.00 years ± 2.54) are compared to 35 healthy age- and IQ-matched healthy children (mean 11.95 years ± 2.36) on a virtual, computer-based equivalent of the Morris Water Maze task. Results: Results indicate that children with anxiety disorder exhibit overall impaired performance relative to the comparison group. Anxious children made more heading direction errors and had worse accuracy in completing trials relative to controls. Conclusions: The results present novel evidence that spatial orientation deficits occur in pediatric anxiety. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02112.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=838

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