Altered amygdala and hippocampus function in adolescents with hypercortisolemia: A functional magnetic resonance imaging study of Cushing syndrome / Françoise S. MAHEU in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1177-1189 Titre : Altered amygdala and hippocampus function in adolescents with hypercortisolemia: A functional magnetic resonance imaging study of Cushing syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Françoise S. MAHEU, Auteur ; Daniel Samuel PINE, Auteur ; Monique ERNST, Auteur ; Luigi MAZZONE, Auteur ; Deborah P. MERKE, Auteur ; Margaret F. KEIL, Auteur ; Constantine A. STRATAKIS, Auteur Année de publication : 2008 Article en page(s) : p.1177-1189 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Chronic elevations of endogenous cortisol levels have been shown to alter medial temporal cortical structures and to be accompanied by declarative memory impairments and depressive symptoms in human adults. These effects of elevated endogenous levels of cortisol have not been directly studied in adolescents. Because adolescents with Cushing syndrome show endogenous elevations in cortisol, they represent a unique natural model to study the effects of prolonged hypercortisolemia on brain function, and memory and affective processes during this developmental stage. Using functional magnetic resonance imaging (fMRI), we compared 12 adolescents with Cushing syndrome with 22 healthy control adolescents on amygdala and anterior hippocampus activation during an emotional faces encoding task. None of these adolescents manifested depressive symptoms. Encoding success was assessed using a memory recognition test performed after the scan. The fMRI analyses followed an event-related design and were conducted using the SPM99 platform. Compared to healthy adolescents, patients with Cushing syndrome showed greater left amygdala and right anterior hippocampus activation during successful face encoding. Memory performance for faces recognition did not differ between groups. This first study of cerebral function in adolescents with chronic endogeneous hypercortisolemia due to Cushing syndrome demonstrates the presence of functional alterations in amygdala and hippocampus, which are not associated with affective or memory impairments. Such findings need to be followed by work examining the role of age and related brain maturational stage on these effects, as well as the identification of possible protective factors conferring resilience to affective and cognitive consequences in this disease and/or during this stage of cerebral development. En ligne : http://dx.doi.org/10.1017/s0954579408000564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602 [article] Altered amygdala and hippocampus function in adolescents with hypercortisolemia: A functional magnetic resonance imaging study of Cushing syndrome [Texte imprimé et/ou numérique] / Françoise S. MAHEU, Auteur ; Daniel Samuel PINE, Auteur ; Monique ERNST, Auteur ; Luigi MAZZONE, Auteur ; Deborah P. MERKE, Auteur ; Margaret F. KEIL, Auteur ; Constantine A. STRATAKIS, Auteur . - 2008 . - p.1177-1189. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1177-1189 Index. décimale : PER Périodiques Résumé : Chronic elevations of endogenous cortisol levels have been shown to alter medial temporal cortical structures and to be accompanied by declarative memory impairments and depressive symptoms in human adults. These effects of elevated endogenous levels of cortisol have not been directly studied in adolescents. Because adolescents with Cushing syndrome show endogenous elevations in cortisol, they represent a unique natural model to study the effects of prolonged hypercortisolemia on brain function, and memory and affective processes during this developmental stage. Using functional magnetic resonance imaging (fMRI), we compared 12 adolescents with Cushing syndrome with 22 healthy control adolescents on amygdala and anterior hippocampus activation during an emotional faces encoding task. None of these adolescents manifested depressive symptoms. Encoding success was assessed using a memory recognition test performed after the scan. The fMRI analyses followed an event-related design and were conducted using the SPM99 platform. Compared to healthy adolescents, patients with Cushing syndrome showed greater left amygdala and right anterior hippocampus activation during successful face encoding. Memory performance for faces recognition did not differ between groups. This first study of cerebral function in adolescents with chronic endogeneous hypercortisolemia due to Cushing syndrome demonstrates the presence of functional alterations in amygdala and hippocampus, which are not associated with affective or memory impairments. Such findings need to be followed by work examining the role of age and related brain maturational stage on these effects, as well as the identification of possible protective factors conferring resilience to affective and cognitive consequences in this disease and/or during this stage of cerebral development. En ligne : http://dx.doi.org/10.1017/s0954579408000564 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602

An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making / Amy L. KRAIN in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1023–1030 Titre : An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making Type de document : Texte imprimé et/ou numérique Auteurs : Amy L. KRAIN, Auteur ; Daniel Samuel PINE, Auteur ; Sara HEFTON, Auteur ; Monique ERNST, Auteur ; Rachel G. KLEIN, Auteur ; Michael P. MILHAM, Auteur ; Francisco Xavier CASTELLANOS, Auteur Année de publication : 2007 Article en page(s) : p.1023–1030 Langues : Anglais (eng) Mots-clés : Adolescence anxiety brain-imaging development Index. décimale : PER Périodiques Résumé : Background: Maturation of prefrontal circuits during adolescence contributes to the development of cognitive processes such as decision-making. Recent theories suggest that these neural changes also play a role in the shift from generalized anxiety disorder (GAD) to depression that often occurs during this developmental period. Cognitive models of the development of GAD highlight the role of intolerance of uncertainty (IU), which can be characterized behaviorally by impairments in decision-making. The present study examines potential developmental differences in frontal regions associated with uncertain decision-making, and tests the impact of IU on these circuits. Methods: Twelve healthy adults (ages 19–36) and 12 healthy adolescents (ages 13–17) completed a decision-making task with conditions of varied uncertainty while fMRI scans were acquired. They also completed measures of worry and IU, and a questionnaire about their levels of anxiety and certainty during the task. Results: Combined group analyses demonstrated significant linear effects of uncertainty on activity within anterior cingulate cortex (ACC). Region of interest (ROI)-based analysis found a significant interaction of group and IU ratings in ACC. Increased IU was associated with robust linear increases in ACC activity only in adolescents. An ROI analysis of feedback-related processing found that adolescents demonstrated greater activation during incorrect trials relative to correct trials, while the adults showed no difference in neural activity associated with incorrect and correct feedback. Conclusions: This decision-making task was shown to be effective at eliciting uncertainty-related ACC activity in adults and adolescents. Further, IU impacts ACC activity in adolescents during uncertain decision-making, providing preliminary support for a developmental model of GAD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01677.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=792 [article] An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making [Texte imprimé et/ou numérique] / Amy L. KRAIN, Auteur ; Daniel Samuel PINE, Auteur ; Sara HEFTON, Auteur ; Monique ERNST, Auteur ; Rachel G. KLEIN, Auteur ; Michael P. MILHAM, Auteur ; Francisco Xavier CASTELLANOS, Auteur . - 2007 . - p.1023–1030. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1023–1030 Mots-clés : Adolescence anxiety brain-imaging development Index. décimale : PER Périodiques Résumé : Background: Maturation of prefrontal circuits during adolescence contributes to the development of cognitive processes such as decision-making. Recent theories suggest that these neural changes also play a role in the shift from generalized anxiety disorder (GAD) to depression that often occurs during this developmental period. Cognitive models of the development of GAD highlight the role of intolerance of uncertainty (IU), which can be characterized behaviorally by impairments in decision-making. The present study examines potential developmental differences in frontal regions associated with uncertain decision-making, and tests the impact of IU on these circuits. Methods: Twelve healthy adults (ages 19–36) and 12 healthy adolescents (ages 13–17) completed a decision-making task with conditions of varied uncertainty while fMRI scans were acquired. They also completed measures of worry and IU, and a questionnaire about their levels of anxiety and certainty during the task. Results: Combined group analyses demonstrated significant linear effects of uncertainty on activity within anterior cingulate cortex (ACC). Region of interest (ROI)-based analysis found a significant interaction of group and IU ratings in ACC. Increased IU was associated with robust linear increases in ACC activity only in adolescents. An ROI analysis of feedback-related processing found that adolescents demonstrated greater activation during incorrect trials relative to correct trials, while the adults showed no difference in neural activity associated with incorrect and correct feedback. Conclusions: This decision-making task was shown to be effective at eliciting uncertainty-related ACC activity in adults and adolescents. Further, IU impacts ACC activity in adolescents during uncertain decision-making, providing preliminary support for a developmental model of GAD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01677.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=792

Assessing gene–environment interactions on anxiety symptom subtypes across childhood and adolescence / Jennifer Y.F. LAU in Development and Psychopathology, 19-4 (Fall 2007)  

Public ISBD [article]  inDevelopment and Psychopathology > 19-4 (Fall 2007) . - p.1129-1146 Titre : Assessing gene–environment interactions on anxiety symptom subtypes across childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer Y.F. LAU, Auteur ; Daniel Samuel PINE, Auteur ; Thalia C. ELEY, Auteur ; Alice M. GREGORY, Auteur ; Michelle A. GOLDWIN, Auteur Année de publication : 2007 Article en page(s) : p.1129-1146 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Consistent evidence shows both genetic and stress-related risks on child and adolescent anxiety, yet few studies have considered the degree to which genetic effects are moderated by stress (gene–environment interaction). We used longitudinal data from both a child and adolescent sample of twins to examine three novel issues on the presence of gene–environment interaction on anxiety symptoms. First, we assessed moderation of genetic risks on anxiety symptoms by negative life events in each age group. Second, by distinguishing between “stable” and “age-specific” genetic factors, we explored the continuity of gene–environment interaction across time and/or its emergence at specific ages. Third, we compared the presence of gene–environment interaction across different symptom types (general, panic, social, and separation). Genetic effects on separation anxiety symptoms in childhood (mean age = 8 years, 6 months) and panic anxiety symptoms in adolescence (mean age = 15 years) increased across independent negative life events. Shared environmental effects on separation anxiety symptoms and nonshared environmental effects on general anxiety symptoms in adolescence were also moderated by negative life events. We interpret these preliminary findings tentatively in the context of gene–environment interaction on anxiety in general, and on early separation and later panic anxiety in particular. En ligne : http://dx.doi.org/10.1017/s0954579407000582 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Assessing gene–environment interactions on anxiety symptom subtypes across childhood and adolescence [Texte imprimé et/ou numérique] / Jennifer Y.F. LAU, Auteur ; Daniel Samuel PINE, Auteur ; Thalia C. ELEY, Auteur ; Alice M. GREGORY, Auteur ; Michelle A. GOLDWIN, Auteur . - 2007 . - p.1129-1146. Langues : Anglais (eng) in Development and Psychopathology > 19-4 (Fall 2007) . - p.1129-1146 Index. décimale : PER Périodiques Résumé : Consistent evidence shows both genetic and stress-related risks on child and adolescent anxiety, yet few studies have considered the degree to which genetic effects are moderated by stress (gene–environment interaction). We used longitudinal data from both a child and adolescent sample of twins to examine three novel issues on the presence of gene–environment interaction on anxiety symptoms. First, we assessed moderation of genetic risks on anxiety symptoms by negative life events in each age group. Second, by distinguishing between “stable” and “age-specific” genetic factors, we explored the continuity of gene–environment interaction across time and/or its emergence at specific ages. Third, we compared the presence of gene–environment interaction across different symptom types (general, panic, social, and separation). Genetic effects on separation anxiety symptoms in childhood (mean age = 8 years, 6 months) and panic anxiety symptoms in adolescence (mean age = 15 years) increased across independent negative life events. Shared environmental effects on separation anxiety symptoms and nonshared environmental effects on general anxiety symptoms in adolescence were also moderated by negative life events. We interpret these preliminary findings tentatively in the context of gene–environment interaction on anxiety in general, and on early separation and later panic anxiety in particular. En ligne : http://dx.doi.org/10.1017/s0954579407000582 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

Attention to novelty in behaviorally inhibited adolescents moderates risk for anxiety / Bethany C. REEB-SUTHERLAND in Journal of Child Psychology and Psychiatry, 50-11 (November 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-11 (November 2009) . - p.1365-1372 Titre : Attention to novelty in behaviorally inhibited adolescents moderates risk for anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Bethany C. REEB-SUTHERLAND, Auteur ; Nathan A. FOX, Auteur ; Daniel Samuel PINE, Auteur ; Peter J. MARSHALL, Auteur ; Ross E. VANDEWERT, Auteur ; Kathryn A. DEGNAN, Auteur ; Koraly PEREZ-EDGAR, Auteur ; Andrea CHRONIS-TUSCANO, Auteur Année de publication : 2009 Article en page(s) : p.1365-1372 Langues : Anglais (eng) Mots-clés : Temperament anxiety adolescence attention risk-factors Index. décimale : PER Périodiques Résumé : Background: Individual differences in specific components of attention contribute to behavioral reactivity and regulation. Children with the temperament of behavioral inhibition (BI) provide a good context for considering the manner in which certain components of attention shape behavior. Infants and children characterized as behaviorally inhibited manifest signs of heightened orienting to novelty. The current study considers whether this attention profile moderates risk for clinical anxiety disorders among adolescents with a history of BI. Methods: Participants were assessed at multiple time points for BI, beginning in early childhood. At adolescence, event-related potentials (ERPs) were recorded during a three-stimulus auditory novelty oddball task, which employed frequent standard and infrequent deviant tones as well as a set of complex, novel sounds. Clinical diagnosis was carried out using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL). P3 and mismatch negativity (MMN) components were examined at midline frontal, central, and parietal electrode sites. Results: Individuals who displayed high levels of BI during childhood and increased P3 amplitude to novelty in adolescence were more likely to have a history of anxiety disorders compared to behaviorally inhibited adolescents with lower P3 amplitudes. Groups did not differ on measures of MMN. Conclusions: Increased neural responses to novelty moderate risk for anxiety disorders amongst individuals with a history of BI. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02170.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=848 [article] Attention to novelty in behaviorally inhibited adolescents moderates risk for anxiety [Texte imprimé et/ou numérique] / Bethany C. REEB-SUTHERLAND, Auteur ; Nathan A. FOX, Auteur ; Daniel Samuel PINE, Auteur ; Peter J. MARSHALL, Auteur ; Ross E. VANDEWERT, Auteur ; Kathryn A. DEGNAN, Auteur ; Koraly PEREZ-EDGAR, Auteur ; Andrea CHRONIS-TUSCANO, Auteur . - 2009 . - p.1365-1372. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-11 (November 2009) . - p.1365-1372 Mots-clés : Temperament anxiety adolescence attention risk-factors Index. décimale : PER Périodiques Résumé : Background: Individual differences in specific components of attention contribute to behavioral reactivity and regulation. Children with the temperament of behavioral inhibition (BI) provide a good context for considering the manner in which certain components of attention shape behavior. Infants and children characterized as behaviorally inhibited manifest signs of heightened orienting to novelty. The current study considers whether this attention profile moderates risk for clinical anxiety disorders among adolescents with a history of BI. Methods: Participants were assessed at multiple time points for BI, beginning in early childhood. At adolescence, event-related potentials (ERPs) were recorded during a three-stimulus auditory novelty oddball task, which employed frequent standard and infrequent deviant tones as well as a set of complex, novel sounds. Clinical diagnosis was carried out using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL). P3 and mismatch negativity (MMN) components were examined at midline frontal, central, and parietal electrode sites. Results: Individuals who displayed high levels of BI during childhood and increased P3 amplitude to novelty in adolescence were more likely to have a history of anxiety disorders compared to behaviorally inhibited adolescents with lower P3 amplitudes. Groups did not differ on measures of MMN. Conclusions: Increased neural responses to novelty moderate risk for anxiety disorders amongst individuals with a history of BI. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02170.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=848

Commentary: Diagnosis and classification: There must be something left about which to argue – reflections on Rutter (2011) / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 52-6 (June 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-6 (June 2011) . - p.663-664 Titre : Commentary: Diagnosis and classification: There must be something left about which to argue – reflections on Rutter (2011) Type de document : Texte imprimé et/ou numérique Auteurs : Daniel Samuel PINE, Auteur Année de publication : 2011 Article en page(s) : p.663-664 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02382.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126 [article] Commentary: Diagnosis and classification: There must be something left about which to argue – reflections on Rutter (2011) [Texte imprimé et/ou numérique] / Daniel Samuel PINE, Auteur . - 2011 . - p.663-664. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-6 (June 2011) . - p.663-664 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02382.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126

Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder / Nancy E. ADLEMAN in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)  

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Editorial / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 48-2 (February 2007)  

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Editorial: Answering questions in developmental science: separating the wheat from the chaff / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 48-12 (December 2007)  

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Editorial: Categories and dimensions: reflections on obsessive-compulsive disorder (OCD) / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)  

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Editorial Commentary: Challenges and potential of DSM-5 and ICD-11 revisions / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 53-5 (May 2012)  

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Editorial: Evaluating new and old treatments for ADHD / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 50-7 (July 2009)  

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Editorial: Lessons learned on the quest to understand developmental psychopathology / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

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Editorial: Putting the ‘clinical’ in clinical neuroscience / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

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Editorial: The difficulties and privileges of the editor / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

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Impaired spatial navigation in pediatric anxiety / Sven C. MUELLER in Journal of Child Psychology and Psychiatry, 50-10 (October 2009)  

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