Gyrification patterns in monozygotic twin pairs varying in discordance for autism / Wendy R. KATES in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.267-278 Titre : Gyrification patterns in monozygotic twin pairs varying in discordance for autism Type de document : Texte imprimé et/ou numérique Auteurs : Wendy R. KATES, Auteur ; Courtney BURNETTE, Auteur ; Ichiro IKUTA, Auteur Année de publication : 2009 Article en page(s) : p.267-278 Langues : Anglais (eng) Mots-clés : Autism twins cortical-gyrification MRI brain Index. décimale : PER Périodiques Résumé : In order to disentangle genetic and environmental contributions to cortical anomalies in children with autism, we investigated cortical folding patterns in a cohort of 14 monozygotic (MZ) twin pairs who displayed a range of phenotypic discordance for autism, and 14 typically developing community controls. Cortical folding was assessed with the gyrification index, which was calculated on high resolution anatomic MR images. We found that the cortical folding patterns across most lobar regions of the cerebral cortex was highly discordant within MZ twin pairs. In addition, children with autism and their co-twins exhibited increased cortical folding in the right parietal lobe, relative to age- and gender-matched typical developing children. Increased folding in the right parietal lobe was associated with more symptoms of autism for co-twins. Finally, the robust association between cortical folding and IQ observed in typical children was not observed in either children with autism or their co-twins. These findings, which contribute to our understanding of the limits of genetic liability in autism, suggest that anomalies in the structural integrity of the cortex in this PDD may disrupt the association between cortical folding and intelligence that has been reported in typical individuals, and may account, in part, for the deficits in visual spatial attention and in social cognition that have been reported in children with autism. En ligne : http://dx.doi.org/10.1002/aur.98 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] Gyrification patterns in monozygotic twin pairs varying in discordance for autism [Texte imprimé et/ou numérique] / Wendy R. KATES, Auteur ; Courtney BURNETTE, Auteur ; Ichiro IKUTA, Auteur . - 2009 . - p.267-278. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.267-278 Mots-clés : Autism twins cortical-gyrification MRI brain Index. décimale : PER Périodiques Résumé : In order to disentangle genetic and environmental contributions to cortical anomalies in children with autism, we investigated cortical folding patterns in a cohort of 14 monozygotic (MZ) twin pairs who displayed a range of phenotypic discordance for autism, and 14 typically developing community controls. Cortical folding was assessed with the gyrification index, which was calculated on high resolution anatomic MR images. We found that the cortical folding patterns across most lobar regions of the cerebral cortex was highly discordant within MZ twin pairs. In addition, children with autism and their co-twins exhibited increased cortical folding in the right parietal lobe, relative to age- and gender-matched typical developing children. Increased folding in the right parietal lobe was associated with more symptoms of autism for co-twins. Finally, the robust association between cortical folding and IQ observed in typical children was not observed in either children with autism or their co-twins. These findings, which contribute to our understanding of the limits of genetic liability in autism, suggest that anomalies in the structural integrity of the cortex in this PDD may disrupt the association between cortical folding and intelligence that has been reported in typical individuals, and may account, in part, for the deficits in visual spatial attention and in social cognition that have been reported in children with autism. En ligne : http://dx.doi.org/10.1002/aur.98 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

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