[article] 
inAutism > 15-3 (May 2011) . - p.285-294

Titre :	Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur
Année de publication :	2011
Article en page(s) :	p.285-294
Langues :	Anglais (eng)
Mots-clés :	autism  disaccharidases  inflammation  intestine
Index. décimale :	PER Périodiques
Résumé :	Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history.
En ligne :	http://dx.doi.org/10.1177/1362361310369142
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130

[article] Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation [Texte imprimé et/ou numérique] / Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur . - 2011 . - p.285-294.
Langues : Anglais (eng)
in Autism > 15-3 (May 2011) . - p.285-294

Mots-clés :	autism  disaccharidases  inflammation  intestine
Index. décimale :	PER Périodiques
Résumé :	Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history.
En ligne :	http://dx.doi.org/10.1177/1362361310369142
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130