A pharmacogenetic study of escitalopram in autism spectrum disorders / Thomas OWLEY in Autism Research, 3-1 (February 2010)  

Public ISBD [article]  inAutism Research > 3-1 (February 2010) . - p.1-7 Titre : A pharmacogenetic study of escitalopram in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Thomas OWLEY, Auteur ; Edwin H. Jr COOK, Auteur ; Bennett L. LEVENTHAL, Auteur ; Camille W. BRUNE, Auteur ; Jeff SALT, Auteur ; Laura WALTON, Auteur ; Steve GUTER, Auteur ; Nelson AYUYAO, Auteur ; Robert D. GIBBONS, Auteur Année de publication : 2010 Article en page(s) : p.1-7 Langues : Anglais (eng) Mots-clés : autistic-disorder escitalopram pharmacogenetics open-label drug-treatment Index. décimale : PER Périodiques Résumé : Objective: To determine the effect of serotonin transporter polymorphism promoter region (5-HTTPLR) genotypic variation (low, intermediate, and high expression groups) on response to escitalopram treatment of children and adolescents with autism spectrum disorders (ASDs). Method: The study used a forced titration, open label design, with genotype blind until study completion. Participants were children and adolescents aged 4-17 years of age with a confirmed ASD (autistic disorder, Asperger's disorder, or pervasive developmental disorder, not otherwise specified). Results: There was an interaction between genotype group and time on the Aberrant Behavior Checklist (ABC) Irritability Subscale (primary outcome variable) (linear maximum marginal likelihood estimation=-4.84, Z=-2.89, SE=1.67, P=0.004). Examination of baseline to last visit revealed that a genotype grouping based on a previous study of platelet 5-HT uptake revealed less response in the genotype group that had S/S genotype for 5-HTTLPR and did not have a diplotype in intron 1 previously shown to be associated with increased platelet 5-HT uptake. Conclusion: This genotype-blind, prospective pharmacogenetic study found the group of subjects with associated with the lowest platelet 5-HT uptake from previous study had the smallest reduction in ABC-Irritability scores after open label treatment with escitalopram. Replication is necessary to confirm these findings. En ligne : http://dx.doi.org/10.1002/aur.109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993 [article] A pharmacogenetic study of escitalopram in autism spectrum disorders [Texte imprimé et/ou numérique] / Thomas OWLEY, Auteur ; Edwin H. Jr COOK, Auteur ; Bennett L. LEVENTHAL, Auteur ; Camille W. BRUNE, Auteur ; Jeff SALT, Auteur ; Laura WALTON, Auteur ; Steve GUTER, Auteur ; Nelson AYUYAO, Auteur ; Robert D. GIBBONS, Auteur . - 2010 . - p.1-7. Langues : Anglais (eng) in Autism Research > 3-1 (February 2010) . - p.1-7 Mots-clés : autistic-disorder escitalopram pharmacogenetics open-label drug-treatment Index. décimale : PER Périodiques Résumé : Objective: To determine the effect of serotonin transporter polymorphism promoter region (5-HTTPLR) genotypic variation (low, intermediate, and high expression groups) on response to escitalopram treatment of children and adolescents with autism spectrum disorders (ASDs). Method: The study used a forced titration, open label design, with genotype blind until study completion. Participants were children and adolescents aged 4-17 years of age with a confirmed ASD (autistic disorder, Asperger's disorder, or pervasive developmental disorder, not otherwise specified). Results: There was an interaction between genotype group and time on the Aberrant Behavior Checklist (ABC) Irritability Subscale (primary outcome variable) (linear maximum marginal likelihood estimation=-4.84, Z=-2.89, SE=1.67, P=0.004). Examination of baseline to last visit revealed that a genotype grouping based on a previous study of platelet 5-HT uptake revealed less response in the genotype group that had S/S genotype for 5-HTTLPR and did not have a diplotype in intron 1 previously shown to be associated with increased platelet 5-HT uptake. Conclusion: This genotype-blind, prospective pharmacogenetic study found the group of subjects with associated with the lowest platelet 5-HT uptake from previous study had the smallest reduction in ABC-Irritability scores after open label treatment with escitalopram. Replication is necessary to confirm these findings. En ligne : http://dx.doi.org/10.1002/aur.109 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=993

The Scottish Centre for Autism Preschool Treatment Programme: I: A Developmental Approach to Early Intervention / Jeff SALT in Autism, 5-4 (December 2001)  

Public ISBD [article]  inAutism > 5-4 (December 2001) . - p.362-373 Titre : The Scottish Centre for Autism Preschool Treatment Programme: I: A Developmental Approach to Early Intervention Type de document : Texte imprimé et/ou numérique Auteurs : Jeff SALT, Auteur ; Val SELLARS, Auteur ; John SHEMILT, Auteur ; Sheila BOYD, Auteur ; Tracey COULSON, Auteur ; Susan MCCOOL, Auteur Article en page(s) : p.362-373 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early intervention is an area of intense current interest for parents and professionals. This article describes a mainstream National Health Service (NHS) approach to early intervention, developed at the Scottish Centre for Autism. The aims of treatment are to improve the child's early social communication and social interaction skills, leading to the potential development of play and flexibility of behaviour. This is achieved by 1:1 intensive treatment by trained therapists, and a schedule of parent training. The treatment protocol incorporates a child led approach; the use of imitation as a therapeutic strategy; using language contingent on activities; and the introduction of flexibility into play and social exchanges. En ligne : http://dx.doi.org/10.1177/1362361301005004003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209 [article] The Scottish Centre for Autism Preschool Treatment Programme: I: A Developmental Approach to Early Intervention [Texte imprimé et/ou numérique] / Jeff SALT, Auteur ; Val SELLARS, Auteur ; John SHEMILT, Auteur ; Sheila BOYD, Auteur ; Tracey COULSON, Auteur ; Susan MCCOOL, Auteur . - p.362-373. Langues : Anglais (eng) in Autism > 5-4 (December 2001) . - p.362-373 Index. décimale : PER Périodiques Résumé : Early intervention is an area of intense current interest for parents and professionals. This article describes a mainstream National Health Service (NHS) approach to early intervention, developed at the Scottish Centre for Autism. The aims of treatment are to improve the child's early social communication and social interaction skills, leading to the potential development of play and flexibility of behaviour. This is achieved by 1:1 intensive treatment by trained therapists, and a schedule of parent training. The treatment protocol incorporates a child led approach; the use of imitation as a therapeutic strategy; using language contingent on activities; and the introduction of flexibility into play and social exchanges. En ligne : http://dx.doi.org/10.1177/1362361301005004003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209

The Scottish Centre for Autism Preschool Treatment Programme: II: The Results of a Controlled Treatment Outcome Study / Jeff SALT in Autism, 6-1 (March 2002)  

Public ISBD [article]  inAutism > 6-1 (March 2002) . - p.33-46 Titre : The Scottish Centre for Autism Preschool Treatment Programme: II: The Results of a Controlled Treatment Outcome Study Type de document : Texte imprimé et/ou numérique Auteurs : Jeff SALT, Auteur ; John SHEMILT, Auteur ; Val SELLARS, Auteur ; Sheila BOYD, Auteur ; Tracey COULSON, Auteur ; Susan MC COOL, Auteur Article en page(s) : p.33-46 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This article evaluates the effectiveness of a developmentally based early intervention programme. Two groups of children were compared, a treatment group and a no-treatment control group. Standardized assessments were administered before and after the intervention period by an independent clinician. Pre-treatment comparisons revealed that the control group had a significantly higher pre-treatment IQ; but the two groups were comparable for age, mental age, socioeconomic status and number of hours of non-experimental therapy. Results demonstrated that children in the treatment group improved significantly more than those in the control group on measures of joint attention, social interaction, imitation, daily living skills, motor skills and an adaptive behaviour composite. A measure of requesting behaviour fell short of statistical significance. The total stress index reduced for treatment group parents and increased for the control group parents (but not significantly). The results of the study are considered to support the efficacy of this treatment approach. En ligne : http://dx.doi.org/10.1177/1362361302006001004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209 [article] The Scottish Centre for Autism Preschool Treatment Programme: II: The Results of a Controlled Treatment Outcome Study [Texte imprimé et/ou numérique] / Jeff SALT, Auteur ; John SHEMILT, Auteur ; Val SELLARS, Auteur ; Sheila BOYD, Auteur ; Tracey COULSON, Auteur ; Susan MC COOL, Auteur . - p.33-46. Langues : Anglais (eng) in Autism > 6-1 (March 2002) . - p.33-46 Index. décimale : PER Périodiques Résumé : This article evaluates the effectiveness of a developmentally based early intervention programme. Two groups of children were compared, a treatment group and a no-treatment control group. Standardized assessments were administered before and after the intervention period by an independent clinician. Pre-treatment comparisons revealed that the control group had a significantly higher pre-treatment IQ; but the two groups were comparable for age, mental age, socioeconomic status and number of hours of non-experimental therapy. Results demonstrated that children in the treatment group improved significantly more than those in the control group on measures of joint attention, social interaction, imitation, daily living skills, motor skills and an adaptive behaviour composite. A measure of requesting behaviour fell short of statistical significance. The total stress index reduced for treatment group parents and increased for the control group parents (but not significantly). The results of the study are considered to support the efficacy of this treatment approach. En ligne : http://dx.doi.org/10.1177/1362361302006001004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=209

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