Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia / Randal G. ROSS in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.535-549 Titre : Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Randal G. ROSS, Auteur ; Catherine ADAMS, Auteur ; Karen E. STEVENS, Auteur ; William R. PROCTOR, Auteur ; Sherry LEONARD, Auteur ; Michael A. KISLEY, Auteur ; Sharon K. HUNTER, Auteur ; Robert FREEDMAN, Auteur Année de publication : 2010 Article en page(s) : p.535-549 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between α7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02187.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Research Review: Cholinergic mechanisms, early brain development, and risk for schizophrenia [Texte imprimé et/ou numérique] / Randal G. ROSS, Auteur ; Catherine ADAMS, Auteur ; Karen E. STEVENS, Auteur ; William R. PROCTOR, Auteur ; Sherry LEONARD, Auteur ; Michael A. KISLEY, Auteur ; Sharon K. HUNTER, Auteur ; Robert FREEDMAN, Auteur . - 2010 . - p.535-549. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.535-549 Index. décimale : PER Périodiques Résumé : The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between α7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02187.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

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