Annual Research Review: Developmental considerations of gene by environment interactions / Rhoshel LENROOT in Journal of Child Psychology and Psychiatry, 52-4 (April 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.429-441 Titre : Annual Research Review: Developmental considerations of gene by environment interactions Type de document : Texte imprimé et/ou numérique Auteurs : Rhoshel LENROOT, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2011 Article en page(s) : p.429-441 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Biological development is driven by a complex dance between nurture and nature, determined not only by the specific features of the interacting genetic and environmental influences but also by the timing of their rendezvous. The initiation of large-scale longitudinal studies, ever-expanding knowledge of genetics, and increasing availability of neuroimaging data to provide endophenotypic bridges between molecules and behavior are beginning to provide some insight into interactions of developmental stage, genes, and the environment, although daunting challenges remain. Prominent amongst these challenges are difficulties in identifying and quantifying relevant environmental factors, discerning the relative contributions to multiply determined outcomes, and the likelihood that brain development is a non-linear dynamic process in which small initial differences may yield large later effects. Age-sensitive mechanisms include developmental changes in gene expression, epigenetic modifications, synaptic arborization/pruning, and maturational improvements in our capacity to seek out environments of our choosing. Greater understanding of how genetic and environmental factors interact differently across ages is an important step toward elucidating the mechanisms by which phenotypes are created – and how they may differ in health and disease. This knowledge may also provide clues to guide the type and timing of interventions to maximize outcomes. En ligne : Development; child; brain; heritability; epigenetics Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 [article] Annual Research Review: Developmental considerations of gene by environment interactions [Texte imprimé et/ou numérique] / Rhoshel LENROOT, Auteur ; Jay N. GIEDD, Auteur . - 2011 . - p.429-441. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-4 (April 2011) . - p.429-441 Index. décimale : PER Périodiques Résumé : Biological development is driven by a complex dance between nurture and nature, determined not only by the specific features of the interacting genetic and environmental influences but also by the timing of their rendezvous. The initiation of large-scale longitudinal studies, ever-expanding knowledge of genetics, and increasing availability of neuroimaging data to provide endophenotypic bridges between molecules and behavior are beginning to provide some insight into interactions of developmental stage, genes, and the environment, although daunting challenges remain. Prominent amongst these challenges are difficulties in identifying and quantifying relevant environmental factors, discerning the relative contributions to multiply determined outcomes, and the likelihood that brain development is a non-linear dynamic process in which small initial differences may yield large later effects. Age-sensitive mechanisms include developmental changes in gene expression, epigenetic modifications, synaptic arborization/pruning, and maturational improvements in our capacity to seek out environments of our choosing. Greater understanding of how genetic and environmental factors interact differently across ages is an important step toward elucidating the mechanisms by which phenotypes are created – and how they may differ in health and disease. This knowledge may also provide clues to guide the type and timing of interventions to maximize outcomes. En ligne : Development; child; brain; heritability; epigenetics Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119

A pediatric twin study of brain morphometry / Gregory L. WALLACE in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.987–993 Titre : A pediatric twin study of brain morphometry Type de document : Texte imprimé et/ou numérique Auteurs : Gregory L. WALLACE, Auteur ; Michael A. ROSENTHAL, Auteur ; Michael C. NEALE, Auteur ; Kenneth S. KENDLER, Auteur ; Liv S. CLASEN, Auteur ; Elizabeth A. MOLLOY, Auteur ; Sarah ORDAZ, Auteur ; Essi VIDING, Auteur ; Rhoshel LENROOT, Auteur ; J. Eric SCHMITT, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2007 Article en page(s) : p.987–993 Langues : Anglais (eng) Mots-clés : Brain-development brain-imaging pediatric twin behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic twins during this developmental period allow exploration of genetic and non-genetic influences on these developmental trajectories. Method: Magnetic resonance imaging brain scans were acquired on a pediatric sample of 90 monozygotic twin pairs, 38 same-sex dyzygotic twin pairs, and 158 unrelated typically developing singletons. Structural equation modeling was used to estimate the additive genetic, common environment, and unique environment effects, as well as age by heritability interactions, on measures of brain volumes from these images. Results: Consistent with previous adult studies, additive genetic effects accounted for a substantial portion of variability in nearly all brain regions with the notable exception of the cerebellum. Significant age by heritability interactions were observed with gray matter volumes showing a reduction in heritability with increasing age, while white matter volume heritability increased with greater age. Conclusion: Understanding the relative contributions of genetic and nongenetic factors on developmental brain trajectories may have implications for better understanding brain-based disorders and typical cognitive development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01676.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788 [article] A pediatric twin study of brain morphometry [Texte imprimé et/ou numérique] / Gregory L. WALLACE, Auteur ; Michael A. ROSENTHAL, Auteur ; Michael C. NEALE, Auteur ; Kenneth S. KENDLER, Auteur ; Liv S. CLASEN, Auteur ; Elizabeth A. MOLLOY, Auteur ; Sarah ORDAZ, Auteur ; Essi VIDING, Auteur ; Rhoshel LENROOT, Auteur ; J. Eric SCHMITT, Auteur ; Jay N. GIEDD, Auteur . - 2007 . - p.987–993. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.987–993 Mots-clés : Brain-development brain-imaging pediatric twin behavioral-genetics Index. décimale : PER Périodiques Résumé : Background: Longitudinal pediatric neuroimaging studies have demonstrated increasing volumes of white matter and regionally-specific inverted U shaped developmental trajectories of gray matter volumes during childhood and adolescence. Studies of monozygotic and dyzygotic twins during this developmental period allow exploration of genetic and non-genetic influences on these developmental trajectories. Method: Magnetic resonance imaging brain scans were acquired on a pediatric sample of 90 monozygotic twin pairs, 38 same-sex dyzygotic twin pairs, and 158 unrelated typically developing singletons. Structural equation modeling was used to estimate the additive genetic, common environment, and unique environment effects, as well as age by heritability interactions, on measures of brain volumes from these images. Results: Consistent with previous adult studies, additive genetic effects accounted for a substantial portion of variability in nearly all brain regions with the notable exception of the cerebellum. Significant age by heritability interactions were observed with gray matter volumes showing a reduction in heritability with increasing age, while white matter volume heritability increased with greater age. Conclusion: Understanding the relative contributions of genetic and nongenetic factors on developmental brain trajectories may have implications for better understanding brain-based disorders and typical cognitive development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01676.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788

The changing impact of genes and environment on brain development during childhood and adolescence: Initial findings from a neuroimaging study of pediatric twins / Rhoshel LENROOT in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1161-1175 Titre : The changing impact of genes and environment on brain development during childhood and adolescence: Initial findings from a neuroimaging study of pediatric twins Type de document : Texte imprimé et/ou numérique Auteurs : Rhoshel LENROOT, Auteur ; Jay N. GIEDD, Auteur Année de publication : 2008 Article en page(s) : p.1161-1175 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Human brain development is created through continuing complex interactions of genetic and environmental influences. The challenge of linking specific genetic or environmental risk factors to typical or atypical behaviors has led to interest in using brain structural features as an intermediate phenotype. Twin studies in adults have found that many aspects of brain anatomy are highly heritable, demonstrating that genetic factors provide a significant contribution to variation in brain structures. Less is known about the relative impact of genes and environment while the brain is actively developing. We summarize results from the ongoing National Institute of Mental Health child and adolescent twin study that suggest that heritability of different brain areas changes over the course of development in a regionally specific fashion. Areas associated with more complex reasoning abilities become increasingly heritable with maturation. The potential mechanisms by which gene–environment interactions may affect heritability values during development is discussed. En ligne : http://dx.doi.org/10.1017/s0954579408000552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602 [article] The changing impact of genes and environment on brain development during childhood and adolescence: Initial findings from a neuroimaging study of pediatric twins [Texte imprimé et/ou numérique] / Rhoshel LENROOT, Auteur ; Jay N. GIEDD, Auteur . - 2008 . - p.1161-1175. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1161-1175 Index. décimale : PER Périodiques Résumé : Human brain development is created through continuing complex interactions of genetic and environmental influences. The challenge of linking specific genetic or environmental risk factors to typical or atypical behaviors has led to interest in using brain structural features as an intermediate phenotype. Twin studies in adults have found that many aspects of brain anatomy are highly heritable, demonstrating that genetic factors provide a significant contribution to variation in brain structures. Less is known about the relative impact of genes and environment while the brain is actively developing. We summarize results from the ongoing National Institute of Mental Health child and adolescent twin study that suggest that heritability of different brain areas changes over the course of development in a regionally specific fashion. Areas associated with more complex reasoning abilities become increasingly heritable with maturation. The potential mechanisms by which gene–environment interactions may affect heritability values during development is discussed. En ligne : http://dx.doi.org/10.1017/s0954579408000552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=602

---

1 (1 - 3 / 3)