[article]
Titre : |
mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur ; Robert J. ROONEY, Auteur ; Diven H. PATEL, Auteur |
Année de publication : |
2010 |
Article en page(s) : |
p.743-750 |
Langues : |
Anglais (eng) |
Mots-clés : |
GABBR1 GABRα4 GABRα5 GABRβ1 Autism Brain |
Index. décimale : |
PER Périodiques |
Résumé : |
We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABRα4; GABRα5; GABRβ1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRα4, GABRα5, GABRβ1) and one demonstrated concordance in cerebellum (GABΒR1). These results provide further evidence of impairment of GABAergic signaling in autism. |
En ligne : |
http://dx.doi.org/10.1007/s10803-009-0924-z |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 |
in Journal of Autism and Developmental Disorders > 40-6 (June 2010) . - p.743-750
[article] mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism [Texte imprimé et/ou numérique] / S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur ; Robert J. ROONEY, Auteur ; Diven H. PATEL, Auteur . - 2010 . - p.743-750. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 40-6 (June 2010) . - p.743-750
Mots-clés : |
GABBR1 GABRα4 GABRα5 GABRβ1 Autism Brain |
Index. décimale : |
PER Périodiques |
Résumé : |
We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABRα4; GABRα5; GABRβ1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRα4, GABRα5, GABRβ1) and one demonstrated concordance in cerebellum (GABΒR1). These results provide further evidence of impairment of GABAergic signaling in autism. |
En ligne : |
http://dx.doi.org/10.1007/s10803-009-0924-z |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 |
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