Brief Report: Risk Variants Could Inform Early Neurodevelopmental Outcome in Children with Developmental Disabilities / Hyeji LEE ; Soowhee KIM ; Kee Jeong PARK ; Joon-Yong AN ; Hyo-Won KIM in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2777-2783 Titre : Brief Report: Risk Variants Could Inform Early Neurodevelopmental Outcome in Children with Developmental Disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Hyeji LEE, Auteur ; Soowhee KIM, Auteur ; Kee Jeong PARK, Auteur ; Joon-Yong AN, Auteur ; Hyo-Won KIM, Auteur Article en page(s) : p.2777-2783 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The aim of this study was to examine genetic variations underlying the early neurodevelopmental outcome of developmental disabilities (DDs). The study cohort consisted of 191 children with DDs. Diagnosis was assessed at baseline and at the index age (72-84 months). Exome sequencing was conducted and putative risk variants were identified. According to the diagnostic improvement, children were categorized into the improvement group (n = 19) and the non-improvement group (n = 172). Compared to the non-improvement group, the improvement group had lower number of risk variants in known DD genes and haploinsufficient genes, and lower number of overall putative risk variants. Our results may serve as a preliminary basis for developing a model that informs clinical outcome by sequencing analysis. En ligne : https://doi.org/10.1007/s10803-022-05735-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Brief Report: Risk Variants Could Inform Early Neurodevelopmental Outcome in Children with Developmental Disabilities [Texte imprimé et/ou numérique] / Hyeji LEE, Auteur ; Soowhee KIM, Auteur ; Kee Jeong PARK, Auteur ; Joon-Yong AN, Auteur ; Hyo-Won KIM, Auteur . - p.2777-2783. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2777-2783 Index. décimale : PER Périodiques Résumé : The aim of this study was to examine genetic variations underlying the early neurodevelopmental outcome of developmental disabilities (DDs). The study cohort consisted of 191 children with DDs. Diagnosis was assessed at baseline and at the index age (72-84 months). Exome sequencing was conducted and putative risk variants were identified. According to the diagnostic improvement, children were categorized into the improvement group (n = 19) and the non-improvement group (n = 172). Compared to the non-improvement group, the improvement group had lower number of risk variants in known DD genes and haploinsufficient genes, and lower number of overall putative risk variants. Our results may serve as a preliminary basis for developing a model that informs clinical outcome by sequencing analysis. En ligne : https://doi.org/10.1007/s10803-022-05735-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Effect of environmental exposure to lead and tobacco smoke on inattentive and hyperactive symptoms and neurocognitive performance in children / Soo-Churl CHO in Journal of Child Psychology and Psychiatry, 51-9 (September 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-9 (September 2010) . - p.1050-1057 Titre : Effect of environmental exposure to lead and tobacco smoke on inattentive and hyperactive symptoms and neurocognitive performance in children Type de document : Texte imprimé et/ou numérique Auteurs : Soo-Churl CHO, Auteur ; Boong-Nyun KIM, Auteur ; Yun-Chul HONG, Auteur ; Min-Sup SHIN, Auteur ; Hee Jeong YOO, Auteur ; Jae-Won KIM, Auteur ; Soo-Young BHANG, Auteur ; In Hee CHO, Auteur ; Hyo-Won KIM, Auteur Année de publication : 2010 Article en page(s) : p.1050-1057 Langues : Anglais (eng) Mots-clés : Attention-deficit-hyperactivity-disorder-(ADHD) cognition environmental-health lead smoking Index. décimale : PER Périodiques Résumé : Background:  The present study assessed the association between blood lead and urinary cotinine levels and inattentive and hyperactive symptoms and neurocognitive performance in children. Methods:  A total of 667 children (age range 8–11) were recruited from nine schools in five Korean cities. The teachers and parents completed the Korean version of the Attention-deficit/hyperactivity disorder Rating Scales (K-ARS), and the children performed neurocognitive tests. Blood lead and urinary cotinine levels were then measured. Results:  The inattentive, hyperactive, and total scores of the teacher-rated K-ARS were positively associated with blood lead level, and the results of the continuous performance test (CPT), Stroop Color–Word Test, and Children’s Color Trails Test were inversely associated with urinary cotinine level when controlled for age, gender, father’s educational level, maternal IQ, child’s IQ, residential area, birth weight, and cotinine (for lead) or lead (for cotinine). The association between blood lead level and commission errors score on the CPT disappeared when the effect of urinary cotinine level was controlled. Conclusions:  These findings indicate that environmental exposure to tobacco smoke in children is associated with poor neurocognitive performance, and low levels of lead are associated with inattention and hyperactivity symptoms. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02250.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Effect of environmental exposure to lead and tobacco smoke on inattentive and hyperactive symptoms and neurocognitive performance in children [Texte imprimé et/ou numérique] / Soo-Churl CHO, Auteur ; Boong-Nyun KIM, Auteur ; Yun-Chul HONG, Auteur ; Min-Sup SHIN, Auteur ; Hee Jeong YOO, Auteur ; Jae-Won KIM, Auteur ; Soo-Young BHANG, Auteur ; In Hee CHO, Auteur ; Hyo-Won KIM, Auteur . - 2010 . - p.1050-1057. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-9 (September 2010) . - p.1050-1057 Mots-clés : Attention-deficit-hyperactivity-disorder-(ADHD) cognition environmental-health lead smoking Index. décimale : PER Périodiques Résumé : Background:  The present study assessed the association between blood lead and urinary cotinine levels and inattentive and hyperactive symptoms and neurocognitive performance in children. Methods:  A total of 667 children (age range 8–11) were recruited from nine schools in five Korean cities. The teachers and parents completed the Korean version of the Attention-deficit/hyperactivity disorder Rating Scales (K-ARS), and the children performed neurocognitive tests. Blood lead and urinary cotinine levels were then measured. Results:  The inattentive, hyperactive, and total scores of the teacher-rated K-ARS were positively associated with blood lead level, and the results of the continuous performance test (CPT), Stroop Color–Word Test, and Children’s Color Trails Test were inversely associated with urinary cotinine level when controlled for age, gender, father’s educational level, maternal IQ, child’s IQ, residential area, birth weight, and cotinine (for lead) or lead (for cotinine). The association between blood lead level and commission errors score on the CPT disappeared when the effect of urinary cotinine level was controlled. Conclusions:  These findings indicate that environmental exposure to tobacco smoke in children is associated with poor neurocognitive performance, and low levels of lead are associated with inattention and hyperactivity symptoms. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02250.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

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