Attention difficulties and mood-related ruminative response style in adolescents with unipolar depression / Paul O. WILKINSON in Journal of Child Psychology and Psychiatry, 47-12 (December 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-12 (December 2006) . - p.1284–1291 Titre : Attention difficulties and mood-related ruminative response style in adolescents with unipolar depression Type de document : texte imprimé Auteurs : Paul O. WILKINSON, Auteur ; Ian M. GOODYER, Auteur Année de publication : 2007 Article en page(s) : p.1284–1291 Langues : Anglais (eng) Mots-clés : Adolescence depression executive-function neuropsychology rumination Index. décimale : PER Périodiques Résumé : Background: Depressed adults may show impairment in switching attention from one task to another. Rumination on negative thoughts is associated with the onset and persistence of depressive episodes. It is unclear if such mood-related ruminations are specifically associated with slowed ability in switching attention from one task to another. Method: Adolescents with current unipolar depression (n = 40) were compared with age and sex-matched controls (n = 38) on tests of attention and general cognitive abilities and completed the mood-related ruminative response style questionnaire. Results: Compared to controls, depressed participants were significantly slower at switching attention. There was no association between attentional switching and mood-related ruminations and both processes contributed to the likelihood of being depressed. Findings were not accounted for by slowness in reading and speaking, the effects of antidepressants nor being more careful on tasks. Conclusions: Depressed adolescents demonstrate dual deficits in mood-related ruminative thinking and attention. Further studies are needed to investigate whether higher ruminations are associated with attention impairments in emotionally-valent attentional switching tasks, and whether both processes precede the emergence of clinical disorder. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01660.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=818 [article] Attention difficulties and mood-related ruminative response style in adolescents with unipolar depression [texte imprimé] / Paul O. WILKINSON, Auteur ; Ian M. GOODYER, Auteur . - 2007 . - p.1284–1291. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-12 (December 2006) . - p.1284–1291 Mots-clés : Adolescence depression executive-function neuropsychology rumination Index. décimale : PER Périodiques Résumé : Background: Depressed adults may show impairment in switching attention from one task to another. Rumination on negative thoughts is associated with the onset and persistence of depressive episodes. It is unclear if such mood-related ruminations are specifically associated with slowed ability in switching attention from one task to another. Method: Adolescents with current unipolar depression (n = 40) were compared with age and sex-matched controls (n = 38) on tests of attention and general cognitive abilities and completed the mood-related ruminative response style questionnaire. Results: Compared to controls, depressed participants were significantly slower at switching attention. There was no association between attentional switching and mood-related ruminations and both processes contributed to the likelihood of being depressed. Findings were not accounted for by slowness in reading and speaking, the effects of antidepressants nor being more careful on tasks. Conclusions: Depressed adolescents demonstrate dual deficits in mood-related ruminative thinking and attention. Further studies are needed to investigate whether higher ruminations are associated with attention impairments in emotionally-valent attentional switching tasks, and whether both processes precede the emergence of clinical disorder. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01660.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=818

Childhood adversity and allostatic overload of the hypothalamic–pituitary–adrenal axis: A vulnerability model for depressive disorders / Paul O. WILKINSON in Development and Psychopathology, 23-4 (November 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-4 (November 2011) . - p.1017-1037 Titre : Childhood adversity and allostatic overload of the hypothalamic–pituitary–adrenal axis: A vulnerability model for depressive disorders Type de document : texte imprimé Auteurs : Paul O. WILKINSON, Auteur ; Ian M. GOODYER, Auteur Année de publication : 2011 Article en page(s) : p.1017-1037 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Childhood adversity is associated with increased risk for onset of depressive episodes. This review will present evidence that allostatic overload of the hypothalamic–pituitary–adrenal axis (HPAA) partially mediates this association. The HPAA is the physiological system that regulates levels of the stress hormone cortisol. First, data from animals and humans has shown that early environmental adversity is associated with long-term dysregulation of the HPAA. This may occur due to permanent epigenetic modification of the glucocorticoid receptor. Second, data from humans has demonstrated that HPAA dysregulation is associated with increased risk of future depression onset in healthy individuals, and pharmacological correction of HPAA dysregulation reduces depressive symptoms. HPAA dysregulation may result in corticoid-mediated abnormalities in neurogenesis in early life and/or neurotoxicity on neural systems that subserve emotion and cognition. En ligne : http://dx.doi.org/10.1017/S0954579411000472 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Childhood adversity and allostatic overload of the hypothalamic–pituitary–adrenal axis: A vulnerability model for depressive disorders [texte imprimé] / Paul O. WILKINSON, Auteur ; Ian M. GOODYER, Auteur . - 2011 . - p.1017-1037. Langues : Anglais (eng) in Development and Psychopathology > 23-4 (November 2011) . - p.1017-1037 Index. décimale : PER Périodiques Résumé : Childhood adversity is associated with increased risk for onset of depressive episodes. This review will present evidence that allostatic overload of the hypothalamic–pituitary–adrenal axis (HPAA) partially mediates this association. The HPAA is the physiological system that regulates levels of the stress hormone cortisol. First, data from animals and humans has shown that early environmental adversity is associated with long-term dysregulation of the HPAA. This may occur due to permanent epigenetic modification of the glucocorticoid receptor. Second, data from humans has demonstrated that HPAA dysregulation is associated with increased risk of future depression onset in healthy individuals, and pharmacological correction of HPAA dysregulation reduces depressive symptoms. HPAA dysregulation may result in corticoid-mediated abnormalities in neurogenesis in early life and/or neurotoxicity on neural systems that subserve emotion and cognition. En ligne : http://dx.doi.org/10.1017/S0954579411000472 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity / Jessica FRITZ in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.411-423 Titre : Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity Type de document : texte imprimé Auteurs : Jessica FRITZ, Auteur ; Jason STRETTON, Auteur ; Adrian Dahl ASKELUND, Auteur ; Susanne SCHWEIZER, Auteur ; Nicholas D. WALSH, Auteur ; Bernet M. ELZINGA, Auteur ; Ian M. GOODYER, Auteur ; Paul O. WILKINSON, Auteur ; Anne-Laura VAN HARMELEN, Auteur Article en page(s) : p.411-423 Langues : Anglais (eng) Mots-clés : anterior insula  dorsal anterior cingulate cortex  mental health resilience  social rejection  social support  that could affect this article. Index. décimale : PER Périodiques Résumé : Childhood adversity (CA) increases the risk of subsequent mental health problems. Adolescent social support (from family and/or friends) reduces the risk of mental health problems after CA. However, the mechanisms of this effect remain unclear, and we speculate that they are manifested on neurodevelopmental levels. Therefore, we investigated whether family and/or friendship support at ages 14 and 17 function as intermediate variables for the relationship between CA before age 11 and affective or neural responses to social rejection feedback at age 18. We studied 55 adolescents with normative mental health at age 18 (26 with CA and therefore considered "resilient"), from a longitudinal cohort. Participants underwent a Social Feedback Task in the magnetic resonance imaging scanner. Social rejection feedback activated the dorsal anterior cingulate cortex and the left anterior insula. CA did not predict affective or neural responses to social rejection at age 18. Yet, CA predicted better friendships at age 14 and age 18, when adolescents with and without CA had comparable mood levels. Thus, adolescents with CA and normative mood levels have more adolescent friendship support and seem to have normal mood and neural responses to social rejection. En ligne : http://dx.doi.org/10.1017/s0954579419000178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity [texte imprimé] / Jessica FRITZ, Auteur ; Jason STRETTON, Auteur ; Adrian Dahl ASKELUND, Auteur ; Susanne SCHWEIZER, Auteur ; Nicholas D. WALSH, Auteur ; Bernet M. ELZINGA, Auteur ; Ian M. GOODYER, Auteur ; Paul O. WILKINSON, Auteur ; Anne-Laura VAN HARMELEN, Auteur . - p.411-423. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.411-423 Mots-clés : anterior insula  dorsal anterior cingulate cortex  mental health resilience  social rejection  social support  that could affect this article. Index. décimale : PER Périodiques Résumé : Childhood adversity (CA) increases the risk of subsequent mental health problems. Adolescent social support (from family and/or friends) reduces the risk of mental health problems after CA. However, the mechanisms of this effect remain unclear, and we speculate that they are manifested on neurodevelopmental levels. Therefore, we investigated whether family and/or friendship support at ages 14 and 17 function as intermediate variables for the relationship between CA before age 11 and affective or neural responses to social rejection feedback at age 18. We studied 55 adolescents with normative mental health at age 18 (26 with CA and therefore considered "resilient"), from a longitudinal cohort. Participants underwent a Social Feedback Task in the magnetic resonance imaging scanner. Social rejection feedback activated the dorsal anterior cingulate cortex and the left anterior insula. CA did not predict affective or neural responses to social rejection at age 18. Yet, CA predicted better friendships at age 14 and age 18, when adolescents with and without CA had comparable mood levels. Thus, adolescents with CA and normative mood levels have more adolescent friendship support and seem to have normal mood and neural responses to social rejection. En ligne : http://dx.doi.org/10.1017/s0954579419000178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Practitioner Review: Therapeutics of unipolar major depressions in adolescents / Ian M. GOODYER in Journal of Child Psychology and Psychiatry, 60-3 (March 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-3 (March 2019) . - p.232-243 Titre : Practitioner Review: Therapeutics of unipolar major depressions in adolescents Type de document : texte imprimé Auteurs : Ian M. GOODYER, Auteur ; Paul O. WILKINSON, Auteur Article en page(s) : p.232-243 Langues : Anglais (eng) Mots-clés : Depression  adolescents  antidepressants  psychotherapies Index. décimale : PER Périodiques Résumé : BACKGROUND: Over the past two decades new and key randomized controlled trials have reported the efficacy, clinical and cost effectiveness of psychological and pharmacological treatments for adolescents with major depression. METHODS: The literature was searched through pubmed, psychinfo, scopus and web of science for randomized controlled trials of current major depression together with meta-analyses and systematic reviews of trials between 2000 and 2017. Those specific to the adolescent years (11-18 years) were taken as the primary source for this narrative review. Additional selected studies in adults were used to illustrate methodological issues. RESULTS: Manualized psychological therapies and the SSRI fluoxetine are more effective than active placebo in the treatment of major depressions. Mild to moderate illnesses attending community-based services are likely to benefit from psychological treatment alone. Moderately to severely ill patients attending clinic and hospital services are likely to benefit from monotherapies or combining psychological and pharmacological treatment. Antidepressants carry a small but significant side-effect risk including increased suicidality. Side effects from psychotherapies are somewhat lower but specific negative consequences remain less well characterized. There is some evidence that CBT-based approaches prevent onset of major depression episode in well adolescents at high-risk. Other psychological interventions have not been adequately studied. There has been only limited identification of treatment moderators and no clear understanding of therapeutic mechanisms. CONCLUSIONS: There is now a range of clinically effective treatments for depressed adolescents. Future research needs to reveal moderators of and mechanisms for individual differences to treatment response, determine psychotherapies of value for milder depressions, enhance our understanding of safety and side-effects for all treatments, and consider how to reduce and treat treatment-resistant cases. En ligne : https://dx.doi.org/10.1111/jcpp.12940 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=385 [article] Practitioner Review: Therapeutics of unipolar major depressions in adolescents [texte imprimé] / Ian M. GOODYER, Auteur ; Paul O. WILKINSON, Auteur . - p.232-243. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-3 (March 2019) . - p.232-243 Mots-clés : Depression  adolescents  antidepressants  psychotherapies Index. décimale : PER Périodiques Résumé : BACKGROUND: Over the past two decades new and key randomized controlled trials have reported the efficacy, clinical and cost effectiveness of psychological and pharmacological treatments for adolescents with major depression. METHODS: The literature was searched through pubmed, psychinfo, scopus and web of science for randomized controlled trials of current major depression together with meta-analyses and systematic reviews of trials between 2000 and 2017. Those specific to the adolescent years (11-18 years) were taken as the primary source for this narrative review. Additional selected studies in adults were used to illustrate methodological issues. RESULTS: Manualized psychological therapies and the SSRI fluoxetine are more effective than active placebo in the treatment of major depressions. Mild to moderate illnesses attending community-based services are likely to benefit from psychological treatment alone. Moderately to severely ill patients attending clinic and hospital services are likely to benefit from monotherapies or combining psychological and pharmacological treatment. Antidepressants carry a small but significant side-effect risk including increased suicidality. Side effects from psychotherapies are somewhat lower but specific negative consequences remain less well characterized. There is some evidence that CBT-based approaches prevent onset of major depression episode in well adolescents at high-risk. Other psychological interventions have not been adequately studied. There has been only limited identification of treatment moderators and no clear understanding of therapeutic mechanisms. CONCLUSIONS: There is now a range of clinically effective treatments for depressed adolescents. Future research needs to reveal moderators of and mechanisms for individual differences to treatment response, determine psychotherapies of value for milder depressions, enhance our understanding of safety and side-effects for all treatments, and consider how to reduce and treat treatment-resistant cases. En ligne : https://dx.doi.org/10.1111/jcpp.12940 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=385

The role of gene–environment correlations and interactions in middle childhood depressive symptoms / Paul O. WILKINSON in Development and Psychopathology, 25-1 (February 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-1 (February 2013) . - p.93-104 Titre : The role of gene–environment correlations and interactions in middle childhood depressive symptoms Type de document : texte imprimé Auteurs : Paul O. WILKINSON, Auteur ; Maciej TRZASKOWSKI, Auteur ; Claire Margaret Alison HAWORTH, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.93-104 Index. décimale : PER Périodiques Résumé : Depression is known to be associated with a wide array of environmental factors. Such associations are due at least in part to genetic influences on both. This issue has been little explored with preadolescent children. Measures of family chaos and parenting style at age 9 and child depressive symptoms at age 12 were completed by 3,258 twin pairs from the Twins Early Development Study and their parents. Quantitative genetic modeling was used to explore common and unique genetic and environmental influences on both family environment and later depressive symptoms. Depressive symptoms at age 12 were significantly heritable. Moderate genetic effects influenced parenting style and family chaos at the age of 9, indicating gene–environment correlation. There were significant genetic correlations between family environment and depressive symptoms. There was some evidence of a Gene × Environment interaction, with stronger genetic effects on depressive symptoms for children with more suboptimal family environment. There was an Environment × Environment interaction, with effects of nonshared environment on depressive symptoms stronger for twins with more adverse parenting experiences. There is some evidence for gene–environment correlation between aspects of family environment in middle childhood and subsequent depressive symptoms. This suggests that one of the mechanisms by which genes lead to depressive symptoms may be by themselves influencing depressogenic environments. En ligne : http://dx.doi.org/10.1017/S0954579412000922 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190 [article] The role of gene–environment correlations and interactions in middle childhood depressive symptoms [texte imprimé] / Paul O. WILKINSON, Auteur ; Maciej TRZASKOWSKI, Auteur ; Claire Margaret Alison HAWORTH, Auteur ; Thalia C. ELEY, Auteur . - p.93-104. in Development and Psychopathology > 25-1 (February 2013) . - p.93-104 Index. décimale : PER Périodiques Résumé : Depression is known to be associated with a wide array of environmental factors. Such associations are due at least in part to genetic influences on both. This issue has been little explored with preadolescent children. Measures of family chaos and parenting style at age 9 and child depressive symptoms at age 12 were completed by 3,258 twin pairs from the Twins Early Development Study and their parents. Quantitative genetic modeling was used to explore common and unique genetic and environmental influences on both family environment and later depressive symptoms. Depressive symptoms at age 12 were significantly heritable. Moderate genetic effects influenced parenting style and family chaos at the age of 9, indicating gene–environment correlation. There were significant genetic correlations between family environment and depressive symptoms. There was some evidence of a Gene × Environment interaction, with stronger genetic effects on depressive symptoms for children with more suboptimal family environment. There was an Environment × Environment interaction, with effects of nonshared environment on depressive symptoms stronger for twins with more adverse parenting experiences. There is some evidence for gene–environment correlation between aspects of family environment in middle childhood and subsequent depressive symptoms. This suggests that one of the mechanisms by which genes lead to depressive symptoms may be by themselves influencing depressogenic environments. En ligne : http://dx.doi.org/10.1017/S0954579412000922 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190

Toward precision therapeutics: general and specific factors differentiate symptom change in depressed adolescents / Madison AITKEN in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

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