Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-α / Stephen B. MANUCK in Development and Psychopathology, 23-1 (January 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-1 (January 2011) . - p.69-83 Titre : Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-α Type de document : Texte imprimé et/ou numérique Auteurs : Stephen B. MANUCK, Auteur ; Anna E. CRAIG, Auteur ; Janine D. FLORY, Auteur ; Indrani HALDER, Auteur ; Robert E. FERRELL, Auteur Année de publication : 2011 Article en page(s) : p.69-83 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Age at menarche, a sentinel index of pubertal maturation, was examined in relation to early family relationships (conflict, cohesion) and polymorphic variation in the gene encoding estrogen receptor-α (ESR1) in a midlife sample of 455 European American women. Consistent with prior literature, women who reported being raised in families characterized by close interpersonal relationships and little conflict tended to reach menarche at a later age than participants reared in families lacking cohesion and prone to discord. Moreover, this association was moderated by ESR1 variation, such that quality of the family environment covaried positively with menarcheal age among participants homozygous for minor alleles of the two ESR1 polymorphisms studied here (rs9304799, rs2234693), but not among women of other ESR1 genotypes. In addition, (a) family relationship variables were unrelated to ESR1 variation, and (b) genotype-dependent effects of childhood environment on age at menarche could not be accounted for by personality traits elsewhere shown to explain heritable variation in reported family conflict and cohesion. These findings are consistent with theories of differential susceptibility to environmental influence, as well as the more specific hypothesis (by Belsky) that girls differ genetically in their sensitivity to rearing effects on pubertal maturation. En ligne : http://dx.doi.org/10.1017/S0954579410000659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-α [Texte imprimé et/ou numérique] / Stephen B. MANUCK, Auteur ; Anna E. CRAIG, Auteur ; Janine D. FLORY, Auteur ; Indrani HALDER, Auteur ; Robert E. FERRELL, Auteur . - 2011 . - p.69-83. Langues : Anglais (eng) in Development and Psychopathology > 23-1 (January 2011) . - p.69-83 Index. décimale : PER Périodiques Résumé : Age at menarche, a sentinel index of pubertal maturation, was examined in relation to early family relationships (conflict, cohesion) and polymorphic variation in the gene encoding estrogen receptor-α (ESR1) in a midlife sample of 455 European American women. Consistent with prior literature, women who reported being raised in families characterized by close interpersonal relationships and little conflict tended to reach menarche at a later age than participants reared in families lacking cohesion and prone to discord. Moreover, this association was moderated by ESR1 variation, such that quality of the family environment covaried positively with menarcheal age among participants homozygous for minor alleles of the two ESR1 polymorphisms studied here (rs9304799, rs2234693), but not among women of other ESR1 genotypes. In addition, (a) family relationship variables were unrelated to ESR1 variation, and (b) genotype-dependent effects of childhood environment on age at menarche could not be accounted for by personality traits elsewhere shown to explain heritable variation in reported family conflict and cohesion. These findings are consistent with theories of differential susceptibility to environmental influence, as well as the more specific hypothesis (by Belsky) that girls differ genetically in their sensitivity to rearing effects on pubertal maturation. En ligne : http://dx.doi.org/10.1017/S0954579410000659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism / Amy L. BYRD in Development and Psychopathology, 31-1 (February 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-1 (February 2019) . - p.361-377 Titre : The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism Type de document : Texte imprimé et/ou numérique Auteurs : Amy L. BYRD, Auteur ; Stephen B. MANUCK, Auteur ; Samuel W. HAWES, Auteur ; Tayler J. VEBARES, Auteur ; Vishwajit NIMGAONKAR, Auteur ; Kodavali V. CHOWDARI, Auteur ; Alison E. HIPWELL, Auteur ; Kate KEENAN, Auteur ; Stephanie D. STEPP, Auteur Article en page(s) : p.361-377 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Research consistently demonstrates that common polymorphic variation in monoamine oxidase A (MAOA) moderates the influence of childhood maltreatment on later antisocial behavior, with growing evidence that the “risk” allele (high vs. low activity) differs for females. However, little is known about how this Gene × Environment interaction functions to increase risk, or if this risk pathway is specific to antisocial behavior. Using a prospectively assessed, longitudinal sample of females (n = 2,004), we examined whether changes in emotional reactivity (ER) during adolescence mediated associations between this Gene × Environment and antisocial personality disorder in early adulthood. In addition, we assessed whether this putative risk pathway also conferred risk for borderline personality disorder, a related disorder characterized by high ER. While direct associations between early maltreatment and later personality pathology did not vary by genotype, there was a significant difference in the indirect path via ER during adolescence. Consistent with hypotheses, females with high-activity MAOA genotype who experienced early maltreatment had greater increases in ER during adolescence, and higher levels of ER predicted both antisocial personality disorder and borderline personality disorder symptom severity. Taken together, findings suggest that the interaction between MAOA and early maltreatment places women at risk for a broader range of personality pathology via effects on ER. En ligne : http://dx.doi.org/10.1017/S0954579417001900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism [Texte imprimé et/ou numérique] / Amy L. BYRD, Auteur ; Stephen B. MANUCK, Auteur ; Samuel W. HAWES, Auteur ; Tayler J. VEBARES, Auteur ; Vishwajit NIMGAONKAR, Auteur ; Kodavali V. CHOWDARI, Auteur ; Alison E. HIPWELL, Auteur ; Kate KEENAN, Auteur ; Stephanie D. STEPP, Auteur . - p.361-377. Langues : Anglais (eng) in Development and Psychopathology > 31-1 (February 2019) . - p.361-377 Index. décimale : PER Périodiques Résumé : Research consistently demonstrates that common polymorphic variation in monoamine oxidase A (MAOA) moderates the influence of childhood maltreatment on later antisocial behavior, with growing evidence that the “risk” allele (high vs. low activity) differs for females. However, little is known about how this Gene × Environment interaction functions to increase risk, or if this risk pathway is specific to antisocial behavior. Using a prospectively assessed, longitudinal sample of females (n = 2,004), we examined whether changes in emotional reactivity (ER) during adolescence mediated associations between this Gene × Environment and antisocial personality disorder in early adulthood. In addition, we assessed whether this putative risk pathway also conferred risk for borderline personality disorder, a related disorder characterized by high ER. While direct associations between early maltreatment and later personality pathology did not vary by genotype, there was a significant difference in the indirect path via ER during adolescence. Consistent with hypotheses, females with high-activity MAOA genotype who experienced early maltreatment had greater increases in ER during adolescence, and higher levels of ER predicted both antisocial personality disorder and borderline personality disorder symptom severity. Taken together, findings suggest that the interaction between MAOA and early maltreatment places women at risk for a broader range of personality pathology via effects on ER. En ligne : http://dx.doi.org/10.1017/S0954579417001900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism – ERRATUM / Amy L. BYRD in Development and Psychopathology, 31-1 (February 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-1 (February 2019) . - p.393-393 Titre : The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism – ERRATUM Type de document : Texte imprimé et/ou numérique Auteurs : Amy L. BYRD, Auteur ; Stephen B. MANUCK, Auteur ; Samuel W. HAWES, Auteur ; Tayler J. VEBARES, Auteur ; Vishwajit NIMGAONKAR, Auteur ; Kodavali V. CHOWDARI, Auteur ; Alison E. HIPWELL, Auteur ; Kate KEENAN, Auteur ; Stephanie D. STEPP, Auteur Article en page(s) : p.393-393 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579418000238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism – ERRATUM [Texte imprimé et/ou numérique] / Amy L. BYRD, Auteur ; Stephen B. MANUCK, Auteur ; Samuel W. HAWES, Auteur ; Tayler J. VEBARES, Auteur ; Vishwajit NIMGAONKAR, Auteur ; Kodavali V. CHOWDARI, Auteur ; Alison E. HIPWELL, Auteur ; Kate KEENAN, Auteur ; Stephanie D. STEPP, Auteur . - p.393-393. Langues : Anglais (eng) in Development and Psychopathology > 31-1 (February 2019) . - p.393-393 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579418000238 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

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