Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms / Sarah WHITTLE in Development and Psychopathology, 23-1 (January 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-1 (January 2011) . - p.115-129 Titre : Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Sarah WHITTLE, Auteur ; Marie B.H. YAP, Auteur ; Lisa B. SHEEBER, Auteur ; Paul DUDGEON, Auteur ; Murat YUCEL, Auteur ; Christos PANTELIS, Auteur ; Julian G. SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur Année de publication : 2011 Article en page(s) : p.115-129 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volumes more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder. En ligne : http://dx.doi.org/10.1017/S0954579410000684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Hippocampal volume and sensitivity to maternal aggressive behavior: A prospective study of adolescent depressive symptoms [Texte imprimé et/ou numérique] / Sarah WHITTLE, Auteur ; Marie B.H. YAP, Auteur ; Lisa B. SHEEBER, Auteur ; Paul DUDGEON, Auteur ; Murat YUCEL, Auteur ; Christos PANTELIS, Auteur ; Julian G. SIMMONS, Auteur ; Nicholas B. ALLEN, Auteur . - 2011 . - p.115-129. Langues : Anglais (eng) in Development and Psychopathology > 23-1 (January 2011) . - p.115-129 Index. décimale : PER Périodiques Résumé : It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volumes more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder. En ligne : http://dx.doi.org/10.1017/S0954579410000684 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

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