[article]
Titre : |
Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Jennifer YUHAS, Auteur ; Lisa CORDEIRO, Auteur ; Flora TASSONE, Auteur ; Elizabeth C. BALLINGER, Auteur ; Andrea SCHNEIDER, Auteur ; James M. LONG, Auteur ; Edward M. ORNITZ, Auteur ; David HESSL, Auteur |
Année de publication : |
2011 |
Article en page(s) : |
p.248-253 |
Note générale : |
Article Open Access |
Langues : |
Anglais (eng) |
Mots-clés : |
PPI FMR1 gene Sensorimotor gating mGluR5 Prepulse inhibition Startle |
Index. décimale : |
PER Périodiques |
Résumé : |
Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS−A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS−A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS−A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating. |
En ligne : |
http://dx.doi.org/10.1007/s10803-010-1040-9 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 |
in Journal of Autism and Developmental Disorders > 41-2 (February 2011) . - p.248-253
[article] Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome [Texte imprimé et/ou numérique] / Jennifer YUHAS, Auteur ; Lisa CORDEIRO, Auteur ; Flora TASSONE, Auteur ; Elizabeth C. BALLINGER, Auteur ; Andrea SCHNEIDER, Auteur ; James M. LONG, Auteur ; Edward M. ORNITZ, Auteur ; David HESSL, Auteur . - 2011 . - p.248-253. Article Open Access Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 41-2 (February 2011) . - p.248-253
Mots-clés : |
PPI FMR1 gene Sensorimotor gating mGluR5 Prepulse inhibition Startle |
Index. décimale : |
PER Périodiques |
Résumé : |
Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS−A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS−A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS−A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating. |
En ligne : |
http://dx.doi.org/10.1007/s10803-010-1040-9 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 |
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