From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process / Arielle R. DEUTSCH in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.845-861 Titre : From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process Type de document : Texte imprimé et/ou numérique Auteurs : Arielle R. DEUTSCH, Auteur ; Wendy S. SLUTSKE, Auteur ; Michael T. LYNSKEY, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Pamela A. F. MADDEN, Auteur ; Andrew C. HEATH, Auteur ; Nicholas G. MARTIN, Auteur Article en page(s) : p.845-861 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the “starting” milestone decreased risk for a shorter time period between the starting and the “ending” milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones. En ligne : http://dx.doi.org/10.1017/s0954579416000523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process [Texte imprimé et/ou numérique] / Arielle R. DEUTSCH, Auteur ; Wendy S. SLUTSKE, Auteur ; Michael T. LYNSKEY, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Pamela A. F. MADDEN, Auteur ; Andrew C. HEATH, Auteur ; Nicholas G. MARTIN, Auteur . - p.845-861. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.845-861 Index. décimale : PER Périodiques Résumé : Abstract The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the “starting” milestone decreased risk for a shorter time period between the starting and the “ending” milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones. En ligne : http://dx.doi.org/10.1017/s0954579416000523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311

Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation / Laurie A. CHASSIN in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.953-67 Titre : Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation Type de document : Texte imprimé et/ou numérique Auteurs : Laurie A. CHASSIN, Auteur ; Matthew R. LEE, Auteur ; Young Il CHO, Auteur ; Frances L. WANG, Auteur ; Arpana AGRAWAL, Auteur ; Kenneth J. SHER, Auteur ; Michael T. LYNSKEY, Auteur Année de publication : 2012 Article en page(s) : p.953-67 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the “traitlike” components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17–23 years) to adulthood (29–40 years). The results for males were consistent with genetically influenced peer selection mechanisms as mediators of parent alcoholism effects. Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages. There was evidence for women of an interaction between OPRM1 variation and peer affiliations but only at the earliest age band. Peer influences had stronger effects among women who were G-carriers. These results illustrate the complex ways in which the interplay between influences at multiple levels of analysis can underlie the intergenerational transmission of alcohol disorders as well as the importance of considering age and gender differences in these pathways. En ligne : http://dx.doi.org/10.1017/S0954579412000478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation [Texte imprimé et/ou numérique] / Laurie A. CHASSIN, Auteur ; Matthew R. LEE, Auteur ; Young Il CHO, Auteur ; Frances L. WANG, Auteur ; Arpana AGRAWAL, Auteur ; Kenneth J. SHER, Auteur ; Michael T. LYNSKEY, Auteur . - 2012 . - p.953-67. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.953-67 Index. décimale : PER Périodiques Résumé : This study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the “traitlike” components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17–23 years) to adulthood (29–40 years). The results for males were consistent with genetically influenced peer selection mechanisms as mediators of parent alcoholism effects. Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages. There was evidence for women of an interaction between OPRM1 variation and peer affiliations but only at the earliest age band. Peer influences had stronger effects among women who were G-carriers. These results illustrate the complex ways in which the interplay between influences at multiple levels of analysis can underlie the intergenerational transmission of alcohol disorders as well as the importance of considering age and gender differences in these pathways. En ligne : http://dx.doi.org/10.1017/S0954579412000478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

The Origins of the Correlations between Tobacco, Alcohol, and Cannabis Use During Adolescence / Michael T. LYNSKEY in Journal of Child Psychology and Psychiatry, 39-7 (October 1998)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 39-7 (October 1998) . - p.995-1005 Titre : The Origins of the Correlations between Tobacco, Alcohol, and Cannabis Use During Adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Michael T. LYNSKEY, Auteur ; David M. FERGUSSON, Auteur ; John L. HORWOOD, Auteur Année de publication : 1998 Article en page(s) : p.995-1005 Langues : Anglais (eng) Mots-clés : Substance use  adolescence  structural equation modelling  longitudinal study Index. décimale : PER Périodiques Résumé : Methods of structural equation modelling were used to analyse the correlations between reports of tobacco, alcohol, and cannabis use in a birth cohort of New Zealand children studied to the age of 16. This analysis produced three major conclusions: (a) the correlations between tobacco, alcohol, and cannabis use could be explained by a factor representing the individual's vulnerability to substance use; (b) predictors of vulnerability to substance use were the extent to which the individual affiliated with delinquent or substance using peers, novelty seeking, and parental illicit drug use; (c) in the region of 54% of the correlations between substance use behaviours could be predicted from observed risk factors and 46% was attributable to non-observed sources of vulnerability. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=123 [article] The Origins of the Correlations between Tobacco, Alcohol, and Cannabis Use During Adolescence [Texte imprimé et/ou numérique] / Michael T. LYNSKEY, Auteur ; David M. FERGUSSON, Auteur ; John L. HORWOOD, Auteur . - 1998 . - p.995-1005. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 39-7 (October 1998) . - p.995-1005 Mots-clés : Substance use  adolescence  structural equation modelling  longitudinal study Index. décimale : PER Périodiques Résumé : Methods of structural equation modelling were used to analyse the correlations between reports of tobacco, alcohol, and cannabis use in a birth cohort of New Zealand children studied to the age of 16. This analysis produced three major conclusions: (a) the correlations between tobacco, alcohol, and cannabis use could be explained by a factor representing the individual's vulnerability to substance use; (b) predictors of vulnerability to substance use were the extent to which the individual affiliated with delinquent or substance using peers, novelty seeking, and parental illicit drug use; (c) in the region of 54% of the correlations between substance use behaviours could be predicted from observed risk factors and 46% was attributable to non-observed sources of vulnerability. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=123

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