[article] 
inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1377-1392

Titre :	Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Stephanie M. SANSONE, Auteur ; Keith F. WIDAMAN, Auteur ; Scott S. HALL, Auteur ; Allan L. REISS, Auteur ; Amy LIGHTBODY, Auteur ; Walter E. KAUFMANN, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Ave LACHIEWICZ, Auteur ; Elaine C. BROWN, Auteur ; David HESSL, Auteur
Année de publication :	2012
Article en page(s) :	p.1377-1392
Langues :	Anglais (eng)
Mots-clés :	FMR1 gene  Fragile X syndrome  Autism  Factor analysis  Rating scale  Social avoidance  Aberrant Behavior Checklist
Index. décimale :	PER Périodiques
Résumé :	Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.
En ligne :	http://dx.doi.org/10.1007/s10803-011-1370-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166

[article] Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment [Texte imprimé et/ou numérique] / Stephanie M. SANSONE, Auteur ; Keith F. WIDAMAN, Auteur ; Scott S. HALL, Auteur ; Allan L. REISS, Auteur ; Amy LIGHTBODY, Auteur ; Walter E. KAUFMANN, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Ave LACHIEWICZ, Auteur ; Elaine C. BROWN, Auteur ; David HESSL, Auteur . - 2012 . - p.1377-1392.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1377-1392

Mots-clés :	FMR1 gene  Fragile X syndrome  Autism  Factor analysis  Rating scale  Social avoidance  Aberrant Behavior Checklist
Index. décimale :	PER Périodiques
Résumé :	Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.
En ligne :	http://dx.doi.org/10.1007/s10803-011-1370-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166