Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment / Stephanie M. SANSONE in Journal of Autism and Developmental Disorders, 42-7 (July 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1377-1392 Titre : Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie M. SANSONE, Auteur ; Keith F. WIDAMAN, Auteur ; Scott S. HALL, Auteur ; Allan L. REISS, Auteur ; Amy LIGHTBODY, Auteur ; Walter E. KAUFMANN, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Ave LACHIEWICZ, Auteur ; Elaine C. BROWN, Auteur ; David HESSL, Auteur Année de publication : 2012 Article en page(s) : p.1377-1392 Langues : Anglais (eng) Mots-clés : FMR1 gene  Fragile X syndrome  Autism  Factor analysis  Rating scale  Social avoidance  Aberrant Behavior Checklist Index. décimale : PER Périodiques Résumé : Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials. En ligne : http://dx.doi.org/10.1007/s10803-011-1370-2 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1660 [article] Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment [Texte imprimé et/ou numérique] / Stephanie M. SANSONE, Auteur ; Keith F. WIDAMAN, Auteur ; Scott S. HALL, Auteur ; Allan L. REISS, Auteur ; Amy LIGHTBODY, Auteur ; Walter E. KAUFMANN, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; Ave LACHIEWICZ, Auteur ; Elaine C. BROWN, Auteur ; David HESSL, Auteur . - 2012 . - p.1377-1392. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-7 (July 2012) . - p.1377-1392 Mots-clés : FMR1 gene  Fragile X syndrome  Autism  Factor analysis  Rating scale  Social avoidance  Aberrant Behavior Checklist Index. décimale : PER Périodiques Résumé : Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials. En ligne : http://dx.doi.org/10.1007/s10803-011-1370-2 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1660

A scoping review of behavioral interventions for promoting social gaze in individuals with autism spectrum disorder and other developmental disabilities / Kristin M. HUSTYI in Research in Autism Spectrum Disorders, 100 (February 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 100 (February 2023) . - 102074 Titre : A scoping review of behavioral interventions for promoting social gaze in individuals with autism spectrum disorder and other developmental disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Kristin M. HUSTYI, Auteur ; Alexa H. RYAN, Auteur ; Scott S. HALL, Auteur Article en page(s) : 102074 Langues : Anglais (eng) Mots-clés : Eye contact  Social gaze  Autism spectrum disorder  Developmental disabilities  Scoping review Index. décimale : PER Périodiques Résumé : Background Individuals diagnosed with autism spectrum disorder (ASD) commonly experience difficulties maintaining social gaze with others during interactions. Although behavioral interventions targeted to promote social gaze in ASD are evident in the literature, to our knowledge, no review of the literature has been conducted to summarize and evaluate the evidence for these interventions. Methods We reviewed and summarized behavioral intervention studies designed to promote social gaze in individuals diagnosed with ASD and other developmental disabilities published in English between 1977 and January 2022 using PsychINFO and PubMed databases. Results 41 studies met the inclusion criteria describing interventions conducted on 608 individuals. A variety of intervention strategies were employed to promote social gaze in these individuals including discrete trial instruction, prompting, modeling, and imitation. Most studies employed single-case research designs and reported successful outcomes, but limited data were available concerning the generalization, maintenance and social validity of these interventions. An increasing number of studies utilized technology-based procedures including computer application gameplay, gaze-contingent eye tracking devices and humanoid robots. Conclusions The present review indicates that behavioral interventions can be successfully employed to promote social gaze in individuals with ASD and other developmental disabilities. However, future research is needed to establish the generalization, maintenance and social validity of these interventions. There are also important ethical issues to be addressed given the increasing divide between treatment advocates and proponents of the neurodiversity movement. En ligne : https://doi.org/10.1016/j.rasd.2022.102074 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4913 [article] A scoping review of behavioral interventions for promoting social gaze in individuals with autism spectrum disorder and other developmental disabilities [Texte imprimé et/ou numérique] / Kristin M. HUSTYI, Auteur ; Alexa H. RYAN, Auteur ; Scott S. HALL, Auteur . - 102074. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 100 (February 2023) . - 102074 Mots-clés : Eye contact  Social gaze  Autism spectrum disorder  Developmental disabilities  Scoping review Index. décimale : PER Périodiques Résumé : Background Individuals diagnosed with autism spectrum disorder (ASD) commonly experience difficulties maintaining social gaze with others during interactions. Although behavioral interventions targeted to promote social gaze in ASD are evident in the literature, to our knowledge, no review of the literature has been conducted to summarize and evaluate the evidence for these interventions. Methods We reviewed and summarized behavioral intervention studies designed to promote social gaze in individuals diagnosed with ASD and other developmental disabilities published in English between 1977 and January 2022 using PsychINFO and PubMed databases. Results 41 studies met the inclusion criteria describing interventions conducted on 608 individuals. A variety of intervention strategies were employed to promote social gaze in these individuals including discrete trial instruction, prompting, modeling, and imitation. Most studies employed single-case research designs and reported successful outcomes, but limited data were available concerning the generalization, maintenance and social validity of these interventions. An increasing number of studies utilized technology-based procedures including computer application gameplay, gaze-contingent eye tracking devices and humanoid robots. Conclusions The present review indicates that behavioral interventions can be successfully employed to promote social gaze in individuals with ASD and other developmental disabilities. However, future research is needed to establish the generalization, maintenance and social validity of these interventions. There are also important ethical issues to be addressed given the increasing divide between treatment advocates and proponents of the neurodiversity movement. En ligne : https://doi.org/10.1016/j.rasd.2022.102074 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4913

A Screening Tool to Measure Eye Contact Avoidance in Boys with Fragile X Syndrome / Scott S. HALL in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2254-2264 Titre : A Screening Tool to Measure Eye Contact Avoidance in Boys with Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Scott S. HALL, Auteur ; Kaitlin M. VENEMA, Auteur Article en page(s) : p.2254-2264 Langues : Anglais (eng) Mots-clés : Fragile X syndrome  Screening tool  Eye gaze  Factor analysis  Psychometrics Index. décimale : PER Périodiques Résumé : We examined the reliability, validity and factor structure of the Eye Contact Avoidance Scale (ECAS), a new 15-item screening tool designed to measure eye contact avoidance in individuals with fragile X syndrome (FXS). Internal consistency of the scale was acceptable to excellent and convergent validity with the Social Responsiveness Scale, Second Edition (SRS-2) and the Anxiety, Depression, and Mood Scale (ADAMS) was good. Boys with a comorbid ASD diagnosis obtained significantly higher scores on the ECAS compared to boys without ASD, when controlling for communication ability. A confirmatory factor analysis indicated that a two-factor model (avoidance and aversion) provided an excellent fit to the data. The ECAS appears to be a promising reliable and valid tool that could be employed as an outcome measure in future pharmacological/behavioral treatment trials for FXS. En ligne : https://doi.org/10.1007/s10803-017-3139-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3144 [article] A Screening Tool to Measure Eye Contact Avoidance in Boys with Fragile X Syndrome [Texte imprimé et/ou numérique] / Scott S. HALL, Auteur ; Kaitlin M. VENEMA, Auteur . - p.2254-2264. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.2254-2264 Mots-clés : Fragile X syndrome  Screening tool  Eye gaze  Factor analysis  Psychometrics Index. décimale : PER Périodiques Résumé : We examined the reliability, validity and factor structure of the Eye Contact Avoidance Scale (ECAS), a new 15-item screening tool designed to measure eye contact avoidance in individuals with fragile X syndrome (FXS). Internal consistency of the scale was acceptable to excellent and convergent validity with the Social Responsiveness Scale, Second Edition (SRS-2) and the Anxiety, Depression, and Mood Scale (ADAMS) was good. Boys with a comorbid ASD diagnosis obtained significantly higher scores on the ECAS compared to boys without ASD, when controlling for communication ability. A confirmatory factor analysis indicated that a two-factor model (avoidance and aversion) provided an excellent fit to the data. The ECAS appears to be a promising reliable and valid tool that could be employed as an outcome measure in future pharmacological/behavioral treatment trials for FXS. En ligne : https://doi.org/10.1007/s10803-017-3139-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3144

The cognitive developmental profile associated with fragile X syndrome: A longitudinal investigation of cognitive strengths and weaknesses through childhood and adolescence / Eve-Marie QUINTIN in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1457-1469 Titre : The cognitive developmental profile associated with fragile X syndrome: A longitudinal investigation of cognitive strengths and weaknesses through childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Eve-Marie QUINTIN, Auteur ; Booil JO, Auteur ; Scott S. HALL, Auteur ; Jennifer L. BRUNO, Auteur ; Lindsay C. CHROMIK, Auteur ; Mira M. RAMAN, Auteur ; Amy A. LIGHTBODY, Auteur ; Arianna MARTIN, Auteur ; Allan L. REISS, Auteur Article en page(s) : p.1457-1469 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Few studies have investigated developmental strengths and weaknesses within the cognitive profile of children and adolescents with fragile X syndrome (FXS), a single-gene cause of inherited intellectual impairment. With a prospective longitudinal design and using normalized raw scores (Z scores) to circumvent floor effects, we measured cognitive functioning of 184 children and adolescents with FXS (ages 6 to 16) using the Wechsler Scale of Intelligence for Children on one to three occasions for each participant. Participants with FXS received lower raw scores relative to the Wechsler Scale of Intelligence for Children normative sample across the developmental period. Verbal comprehension, perceptual organization, and processing speed Z scores were marked by a widening gap from the normative sample, while freedom from distractibility Z scores showed a narrowing gap. Key findings include a relative strength for verbal skills in comparison with visuospatial–constructive skills arising in adolescence and a discrepancy between working memory (weakness) and processing speed (strength) in childhood that diminishes in adolescence. Results suggest that the cognitive profile associated with FXS develops dynamically from childhood to adolescence. Findings are discussed within the context of aberrant brain morphology in childhood and maturation in adolescence. We argue that assessing disorder-specific cognitive developmental profiles will benefit future disorder-specific treatment research. En ligne : http://dx.doi.org/10.1017/s0954579415001200 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2944 [article] The cognitive developmental profile associated with fragile X syndrome: A longitudinal investigation of cognitive strengths and weaknesses through childhood and adolescence [Texte imprimé et/ou numérique] / Eve-Marie QUINTIN, Auteur ; Booil JO, Auteur ; Scott S. HALL, Auteur ; Jennifer L. BRUNO, Auteur ; Lindsay C. CHROMIK, Auteur ; Mira M. RAMAN, Auteur ; Amy A. LIGHTBODY, Auteur ; Arianna MARTIN, Auteur ; Allan L. REISS, Auteur . - p.1457-1469. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1457-1469 Index. décimale : PER Périodiques Résumé : Few studies have investigated developmental strengths and weaknesses within the cognitive profile of children and adolescents with fragile X syndrome (FXS), a single-gene cause of inherited intellectual impairment. With a prospective longitudinal design and using normalized raw scores (Z scores) to circumvent floor effects, we measured cognitive functioning of 184 children and adolescents with FXS (ages 6 to 16) using the Wechsler Scale of Intelligence for Children on one to three occasions for each participant. Participants with FXS received lower raw scores relative to the Wechsler Scale of Intelligence for Children normative sample across the developmental period. Verbal comprehension, perceptual organization, and processing speed Z scores were marked by a widening gap from the normative sample, while freedom from distractibility Z scores showed a narrowing gap. Key findings include a relative strength for verbal skills in comparison with visuospatial–constructive skills arising in adolescence and a discrepancy between working memory (weakness) and processing speed (strength) in childhood that diminishes in adolescence. Results suggest that the cognitive profile associated with FXS develops dynamically from childhood to adolescence. Findings are discussed within the context of aberrant brain morphology in childhood and maturation in adolescence. We argue that assessing disorder-specific cognitive developmental profiles will benefit future disorder-specific treatment research. En ligne : http://dx.doi.org/10.1017/s0954579415001200 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2944

The Relationship Between Autistic Symptomatology and Independent Living Skills in Adolescents and Young Adults with Fragile X Syndrome / Kristin M. HUSTYI in Journal of Autism and Developmental Disorders, 45-6 (June 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1836-1844 Titre : The Relationship Between Autistic Symptomatology and Independent Living Skills in Adolescents and Young Adults with Fragile X Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Kristin M. HUSTYI, Auteur ; Scott S. HALL, Auteur ; Eve-Marie QUINTIN, Auteur ; Lindsay C. CHROMIK, Auteur ; Amy A. LIGHTBODY, Auteur ; Allan L. REISS, Auteur Article en page(s) : p.1836-1844 Langues : Anglais (eng) Mots-clés : Fragile X syndrome  Functional skills  Independent living skills  Autistic symptomatology Index. décimale : PER Périodiques Résumé : Few studies have examined the relationship between autistic symptomatology and competence in independent living skills in adolescents and young adults with fragile X syndrome (FXS). In this study, 70 individuals with FXS, aged 15–25 years, and 35 matched controls were administered direct measures of independent living skills and autistic symptomatology. Results showed that higher levels of autistic symptomatology were associated with lower levels of competence in independent living skills in individuals with FXS, but not in controls. These data indicated that the relationship between autistic symptomatology and independent living skills was syndrome-specific. Early intervention strategies that address autistic symptomatology are sorely needed to improve functional outcomes in this population. En ligne : http://dx.doi.org/10.1007/s10803-014-2342-0 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2596 [article] The Relationship Between Autistic Symptomatology and Independent Living Skills in Adolescents and Young Adults with Fragile X Syndrome [Texte imprimé et/ou numérique] / Kristin M. HUSTYI, Auteur ; Scott S. HALL, Auteur ; Eve-Marie QUINTIN, Auteur ; Lindsay C. CHROMIK, Auteur ; Amy A. LIGHTBODY, Auteur ; Allan L. REISS, Auteur . - p.1836-1844. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-6 (June 2015) . - p.1836-1844 Mots-clés : Fragile X syndrome  Functional skills  Independent living skills  Autistic symptomatology Index. décimale : PER Périodiques Résumé : Few studies have examined the relationship between autistic symptomatology and competence in independent living skills in adolescents and young adults with fragile X syndrome (FXS). In this study, 70 individuals with FXS, aged 15–25 years, and 35 matched controls were administered direct measures of independent living skills and autistic symptomatology. Results showed that higher levels of autistic symptomatology were associated with lower levels of competence in independent living skills in individuals with FXS, but not in controls. These data indicated that the relationship between autistic symptomatology and independent living skills was syndrome-specific. Early intervention strategies that address autistic symptomatology are sorely needed to improve functional outcomes in this population. En ligne : http://dx.doi.org/10.1007/s10803-014-2342-0 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2596

Using Discrete Trial Training to Identify Specific Learning Impairments in Boys with Fragile X Syndrome / Scott S. HALL in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

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