[article]
| Titre : |
Time-of-day effects in arousal: disrupted diurnal cortisol profiles in children with ADHD |
| Type de document : |
texte imprimé |
| Auteurs : |
Lindita IMERAJ, Auteur ; Inge ANTROP, Auteur ; Herbert ROEYERS, Auteur ; James D. SWANSON, Auteur ; Ellen DESCHEPPE, Auteur ; Sarah BAL, Auteur ; Dirk DEBOUTTE, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p.782-789 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
ADHD ODD circadian HPA axis cortisol arousal |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background: Fluctuations in attention-deficit hyperactivity disorder (ADHD) symptoms related to regulatory deficits in arousal states are themselves characterized by circadian rhythms. Although cortisol is an important circadian arousal-related marker, studies focusing on across-the-day cortisol variations in ADHD are scarce. There is no study with multiple measurements to take into account interday and intraday variability.
Methods: Salivary cortisol was sampled five times a day (awakening, 30 min after awakening, noon, 4 p.m., 8 p.m.) across five consecutive days in 33 children with ADHD (22 with and 11 without oppositional defiant disorder; ODD) and 33 class- and sex-matched controls (aged 6–12). The cortisol awakening response (increase from awakening to 30 min after awakening) and the diurnal cortisol profile (across-the-day variations) were compared for ADHD with ODD (ADHD + ODD) and without ODD (ADHD) subgroups and the control group.
Results: The cortisol awakening response was not significantly different between groups. However, longitudinal analyses to evaluate cortisol profiles across the day revealed a significant Group × Time effect (p < .001). More specifically, compared to each other, the ADHD subgroup showed a flatter slope with relative morning hypo-arousal and evening hyperarousal, whereas the ADHD + ODD subgroup showed a steeper slope with relative morning hyperarousal and evening hypo-arousal (p < .001).
Conclusions: Findings support time-related arousal disruptions in children with ADHD associated with the presence or absence of ODD comorbidity. We recommend research on cortisol in larger samples for a better understanding of arousal mechanisms involved in ADHD not only with and without ODD but also with other comorbidities which may have implications for timing of arousal-based treatments. |
| En ligne : |
http://dx.doi.org/10.1111/j.1469-7610.2012.02526.x |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 |
in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.782-789
[article] Time-of-day effects in arousal: disrupted diurnal cortisol profiles in children with ADHD [texte imprimé] / Lindita IMERAJ, Auteur ; Inge ANTROP, Auteur ; Herbert ROEYERS, Auteur ; James D. SWANSON, Auteur ; Ellen DESCHEPPE, Auteur ; Sarah BAL, Auteur ; Dirk DEBOUTTE, Auteur . - 2012 . - p.782-789. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.782-789
| Mots-clés : |
ADHD ODD circadian HPA axis cortisol arousal |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background: Fluctuations in attention-deficit hyperactivity disorder (ADHD) symptoms related to regulatory deficits in arousal states are themselves characterized by circadian rhythms. Although cortisol is an important circadian arousal-related marker, studies focusing on across-the-day cortisol variations in ADHD are scarce. There is no study with multiple measurements to take into account interday and intraday variability.
Methods: Salivary cortisol was sampled five times a day (awakening, 30 min after awakening, noon, 4 p.m., 8 p.m.) across five consecutive days in 33 children with ADHD (22 with and 11 without oppositional defiant disorder; ODD) and 33 class- and sex-matched controls (aged 6–12). The cortisol awakening response (increase from awakening to 30 min after awakening) and the diurnal cortisol profile (across-the-day variations) were compared for ADHD with ODD (ADHD + ODD) and without ODD (ADHD) subgroups and the control group.
Results: The cortisol awakening response was not significantly different between groups. However, longitudinal analyses to evaluate cortisol profiles across the day revealed a significant Group × Time effect (p < .001). More specifically, compared to each other, the ADHD subgroup showed a flatter slope with relative morning hypo-arousal and evening hyperarousal, whereas the ADHD + ODD subgroup showed a steeper slope with relative morning hyperarousal and evening hypo-arousal (p < .001).
Conclusions: Findings support time-related arousal disruptions in children with ADHD associated with the presence or absence of ODD comorbidity. We recommend research on cortisol in larger samples for a better understanding of arousal mechanisms involved in ADHD not only with and without ODD but also with other comorbidities which may have implications for timing of arousal-based treatments. |
| En ligne : |
http://dx.doi.org/10.1111/j.1469-7610.2012.02526.x |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 |
|  |
Time-of-day effects in arousal: disrupted diurnal cortisol profiles in children with ADHD in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)
