Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 / Allen J. ROSENSPIRE in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.242-249 Titre : Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 Type de document : Texte imprimé et/ou numérique Auteurs : Allen J. ROSENSPIRE, Auteur ; Wonsuk YOO, Auteur ; Sherri MENARD, Auteur ; Anthony R. TORRES, Auteur Année de publication : 2011 Article en page(s) : p.242-249 Langues : Anglais (eng) Mots-clés : immunology  anti-transglutaminase antibody  pediatrics Index. décimale : PER Périodiques Résumé : We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. En ligne : http://dx.doi.org/10.1002/aur.194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 [Texte imprimé et/ou numérique] / Allen J. ROSENSPIRE, Auteur ; Wonsuk YOO, Auteur ; Sherri MENARD, Auteur ; Anthony R. TORRES, Auteur . - 2011 . - p.242-249. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.242-249 Mots-clés : immunology  anti-transglutaminase antibody  pediatrics Index. décimale : PER Périodiques Résumé : We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. En ligne : http://dx.doi.org/10.1002/aur.194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

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