Antipsychotics in the Treatment of Autism / Carmem GOTTFRIED  

Public ISBD in Autism Spectrum Disorders - From Genes to Environment / Tim WILLIAMS Titre : Antipsychotics in the Treatment of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Carmem GOTTFRIED, Auteur ; Rudimar RIESGO, Auteur Année de publication : 2011 Importance : p.23-46 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 in Autism Spectrum Disorders - From Genes to Environment / Tim WILLIAMS Antipsychotics in the Treatment of Autism [Texte imprimé et/ou numérique] / Carmem GOTTFRIED, Auteur ; Rudimar RIESGO, Auteur . - 2011 . - p.23-46. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143

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A comprehensive bioinformatics analysis of circRNA expression in the brain of distinct mouse models of Autism Spectrum Disorder / Guilherme Cordenonsi DA FONSECA ; Carmem GOTTFRIED in Research in Autism Spectrum Disorders, 109 (November 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 109 (November 2023) . - 102261 Titre : A comprehensive bioinformatics analysis of circRNA expression in the brain of distinct mouse models of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Guilherme Cordenonsi DA FONSECA, Auteur ; Carmem GOTTFRIED, Auteur Article en page(s) : 102261 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Animal models  Circular RNA  Bioinformatics  NcRNAs Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a neurodevelopmental condition estimated to affect 1% of individuals worldwide. Its etiology is still not fully understood, but several molecular alterations in ASD are related to noncoding RNAs (ncRNAs). Recently, gene expression of circular RNAs (circRNAs) has been shown to be altered in the brains of autistic individuals and two animal models of ASD. Here we use bioinformatics methods to analyze the gene expression of circRNAs in the brain of six distinct animal models of ASD and identify possible alterations shared between models and between models and humans. Method: six publicly available RNA-Seq data sets were used. CircRNAs were identified by a combination of algorithms using CirComPara2 software. Differentially expressed circRNAs (DECs) were evaluatedwith the Limma Voom method, and the functional profile was evaluated with clusterProfiler. Databases of risk genes and circRNAs altered in ASD were used for translational comparison. Results: We have identified over 130,000 unique circRNAs. DECs per se are shared by a few animal models. However, functional analysis revealed that the DECs from distinct models share a similar profile of changes, mostly related to synaptic structure and function. Regarding translational alterations, around 2% of DECs in mice are orthologous to DECs in autistic individuals. Conclusions: We provide an overview of the expression of circRNAs in mouse models of ASD. The analyses indicate that synaptic circRNAs may be central to the alterations found. We hope the broad identification of circRNAs can help researchers further explore their selected mouse models. En ligne : https://doi.org/10.1016/j.rasd.2023.102261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] A comprehensive bioinformatics analysis of circRNA expression in the brain of distinct mouse models of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Guilherme Cordenonsi DA FONSECA, Auteur ; Carmem GOTTFRIED, Auteur . - 102261. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 109 (November 2023) . - 102261 Mots-clés : Autism spectrum disorder  Animal models  Circular RNA  Bioinformatics  NcRNAs Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a neurodevelopmental condition estimated to affect 1% of individuals worldwide. Its etiology is still not fully understood, but several molecular alterations in ASD are related to noncoding RNAs (ncRNAs). Recently, gene expression of circular RNAs (circRNAs) has been shown to be altered in the brains of autistic individuals and two animal models of ASD. Here we use bioinformatics methods to analyze the gene expression of circRNAs in the brain of six distinct animal models of ASD and identify possible alterations shared between models and between models and humans. Method: six publicly available RNA-Seq data sets were used. CircRNAs were identified by a combination of algorithms using CirComPara2 software. Differentially expressed circRNAs (DECs) were evaluatedwith the Limma Voom method, and the functional profile was evaluated with clusterProfiler. Databases of risk genes and circRNAs altered in ASD were used for translational comparison. Results: We have identified over 130,000 unique circRNAs. DECs per se are shared by a few animal models. However, functional analysis revealed that the DECs from distinct models share a similar profile of changes, mostly related to synaptic structure and function. Regarding translational alterations, around 2% of DECs in mice are orthologous to DECs in autistic individuals. Conclusions: We provide an overview of the expression of circRNAs in mouse models of ASD. The analyses indicate that synaptic circRNAs may be central to the alterations found. We hope the broad identification of circRNAs can help researchers further explore their selected mouse models. En ligne : https://doi.org/10.1016/j.rasd.2023.102261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Effect of a ketogenic diet on autism spectrum disorder: A systematic review / Kamila CASTRO in Research in Autism Spectrum Disorders, 20 (December 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 20 (December 2015) . - p.31-38 Titre : Effect of a ketogenic diet on autism spectrum disorder: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Kamila CASTRO, Auteur ; Larissa Slongo FACCIOLI, Auteur ; Diego BARONIO, Auteur ; Carmem GOTTFRIED, Auteur ; Ingrid Schweigert PERRY, Auteur ; Rudimar DOS SANTOS RIESGO, Auteur Article en page(s) : p.31-38 Langues : Anglais (eng) Mots-clés : Autistic disorder  Ketogenic diet  Behavioural symptoms Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is primarily characterized by impaired social interaction and communication, as well as restricted repetitive behaviours and interests. The utilization of the ketogenic diet (KD) in different neurological disorders has become a valid approach over time, and recently, it has also been advocated as a potential therapeutic for ASD. A MEDLINE, Scopus and Cochrane search was performed by two independent reviewers to investigate the relationship between ASD and the KD in humans and experimental studies. Of the eighty-one potentially relevant articles, eight articles met the inclusion criteria: three studies with animals and five studies with humans. The consistency between reviewers was ? = 0.817. In humans, the studies mainly focused on the behavioural outcomes provided by this diet and reported ameliorated behavioural symptoms via an improved score in the Childhood Autism Rating Scale (CARS). The KD in prenatal valproic acid (VPA)-exposed rodents, as well as in BTBR and Mecp2 mice strains, resulted in an attenuation of some autistic-like features. The limited number of reports of improvements after treatment with the KD is insufficient to attest to the practicability of the KD as a treatment for ASD, but it is still a good indicator that this diet is a promising therapeutic option for this disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Effect of a ketogenic diet on autism spectrum disorder: A systematic review [Texte imprimé et/ou numérique] / Kamila CASTRO, Auteur ; Larissa Slongo FACCIOLI, Auteur ; Diego BARONIO, Auteur ; Carmem GOTTFRIED, Auteur ; Ingrid Schweigert PERRY, Auteur ; Rudimar DOS SANTOS RIESGO, Auteur . - p.31-38. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 20 (December 2015) . - p.31-38 Mots-clés : Autistic disorder  Ketogenic diet  Behavioural symptoms Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is primarily characterized by impaired social interaction and communication, as well as restricted repetitive behaviours and interests. The utilization of the ketogenic diet (KD) in different neurological disorders has become a valid approach over time, and recently, it has also been advocated as a potential therapeutic for ASD. A MEDLINE, Scopus and Cochrane search was performed by two independent reviewers to investigate the relationship between ASD and the KD in humans and experimental studies. Of the eighty-one potentially relevant articles, eight articles met the inclusion criteria: three studies with animals and five studies with humans. The consistency between reviewers was ? = 0.817. In humans, the studies mainly focused on the behavioural outcomes provided by this diet and reported ameliorated behavioural symptoms via an improved score in the Childhood Autism Rating Scale (CARS). The KD in prenatal valproic acid (VPA)-exposed rodents, as well as in BTBR and Mecp2 mice strains, resulted in an attenuation of some autistic-like features. The limited number of reports of improvements after treatment with the KD is insufficient to attest to the practicability of the KD as a treatment for ASD, but it is still a good indicator that this diet is a promising therapeutic option for this disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

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