3494 recherche sur le mot-clé 'Autism spectrum disorder'

Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence from the Brain Imaging Abnormalities in 2–3 Years Old Toddlers / Zhou XIAO in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1633-1640 Titre : Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence from the Brain Imaging Abnormalities in 2–3 Years Old Toddlers Type de document : Texte imprimé et/ou numérique Auteurs : Zhou XIAO, Auteur ; Ting QIU, Auteur ; Xiaoyan KE, Auteur ; Xiang XIAO, Auteur ; Ting XIAO, Auteur ; Fengjing LIANG, Auteur ; Bing ZOU, Auteur ; Haiqing HUANG, Auteur ; Hui FANG, Auteur ; Kangkang CHU, Auteur ; Jiuping ZHANG, Auteur ; Yijun LIU, Auteur Article en page(s) : p.1633-1640 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Toddler  Magnetic resonance imaging  Voxel based morphometry  Diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that occurs within the first 3 years of life, which is marked by social skills and communication deficits along with stereotyped repetitive behavior. Although great efforts have been made to clarify the underlying neuroanatomical abnormalities and brain-behavior relationships in adolescents and adults with ASD, literature is still limited in information about the neurobiology of ASD in the early age of life. Brain images of 50 toddlers with ASD and 28 age, gender, and developmental quotient matched toddlers with developmental delay (DD) (control group) between ages 2 and 3 years were captured using combined magnetic resonance-based structural imaging and diffusion tensor imaging (DTI). Structural magnetic resonance imaging was applied to assess overall gray matter (GM) and white matter (WM) volumes, and regional alterations were assessed by voxel-based morphometry. DTI was used to investigate the white matter tract integrity. Compared with DD, significant increases were observed in ASD, primarily in global GM and WM volumes and in right superior temporal gyrus regional GM and WM volumes. Higher fractional anisotropy value was also observed in the corpus callosum, posterior cingulate cortex, and limbic lobes of ASD. The converging findings of structural and white matter abnormalities in ASD suggest that alterations in neural-anatomy of different brain regions may be involved in behavioral and cognitive deficits associated with ASD, especially in an early age of 2–3 years old toddlers. En ligne : http://dx.doi.org/10.1007/s10803-014-2033-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence from the Brain Imaging Abnormalities in 2–3 Years Old Toddlers [Texte imprimé et/ou numérique] / Zhou XIAO, Auteur ; Ting QIU, Auteur ; Xiaoyan KE, Auteur ; Xiang XIAO, Auteur ; Ting XIAO, Auteur ; Fengjing LIANG, Auteur ; Bing ZOU, Auteur ; Haiqing HUANG, Auteur ; Hui FANG, Auteur ; Kangkang CHU, Auteur ; Jiuping ZHANG, Auteur ; Yijun LIU, Auteur . - p.1633-1640. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1633-1640 Mots-clés : Autism spectrum disorder  Toddler  Magnetic resonance imaging  Voxel based morphometry  Diffusion tensor imaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that occurs within the first 3 years of life, which is marked by social skills and communication deficits along with stereotyped repetitive behavior. Although great efforts have been made to clarify the underlying neuroanatomical abnormalities and brain-behavior relationships in adolescents and adults with ASD, literature is still limited in information about the neurobiology of ASD in the early age of life. Brain images of 50 toddlers with ASD and 28 age, gender, and developmental quotient matched toddlers with developmental delay (DD) (control group) between ages 2 and 3 years were captured using combined magnetic resonance-based structural imaging and diffusion tensor imaging (DTI). Structural magnetic resonance imaging was applied to assess overall gray matter (GM) and white matter (WM) volumes, and regional alterations were assessed by voxel-based morphometry. DTI was used to investigate the white matter tract integrity. Compared with DD, significant increases were observed in ASD, primarily in global GM and WM volumes and in right superior temporal gyrus regional GM and WM volumes. Higher fractional anisotropy value was also observed in the corpus callosum, posterior cingulate cortex, and limbic lobes of ASD. The converging findings of structural and white matter abnormalities in ASD suggest that alterations in neural-anatomy of different brain regions may be involved in behavioral and cognitive deficits associated with ASD, especially in an early age of 2–3 years old toddlers. En ligne : http://dx.doi.org/10.1007/s10803-014-2033-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

Autism Spectrum Disorder: FRAXE Mutation, a Rare Etiology / F. CORREIA in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.888-892 Titre : Autism Spectrum Disorder: FRAXE Mutation, a Rare Etiology Type de document : Texte imprimé et/ou numérique Auteurs : F. CORREIA, Auteur ; C. CAFE, Auteur ; J. ALMEIDA, Auteur ; S. MOUGA, Auteur ; G. OLIVEIRA, Auteur Article en page(s) : p.888-892 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Fragile X syndrome  FRAXE  FMR2  Intellectual disability  Compulsive behavior problems Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social interaction and communication, restricted interests and repetitive behaviors. Fragile X E is associated with X-linked non-specific mild intellectual disability (ID) and with behavioral problems. Most of the known genetic causes of ASD are also causes of ID, implying that these two identities share common genetic bases. We present a child with an ASD with a normal range of intelligence quotient, that later evolved to compulsive behavior. FRAXE locus analysis by polymerase chain reaction revealed a complete mutation of the FMR 2 gene. This report stresses the importance of clinicians being aware of the association between a full mutation of FMR2 and ASD associated with compulsive behavior despite normal intellectual level. En ligne : http://dx.doi.org/10.1007/s10803-014-2185-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Autism Spectrum Disorder: FRAXE Mutation, a Rare Etiology [Texte imprimé et/ou numérique] / F. CORREIA, Auteur ; C. CAFE, Auteur ; J. ALMEIDA, Auteur ; S. MOUGA, Auteur ; G. OLIVEIRA, Auteur . - p.888-892. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.888-892 Mots-clés : Autism spectrum disorder  Fragile X syndrome  FRAXE  FMR2  Intellectual disability  Compulsive behavior problems Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social interaction and communication, restricted interests and repetitive behaviors. Fragile X E is associated with X-linked non-specific mild intellectual disability (ID) and with behavioral problems. Most of the known genetic causes of ASD are also causes of ID, implying that these two identities share common genetic bases. We present a child with an ASD with a normal range of intelligence quotient, that later evolved to compulsive behavior. FRAXE locus analysis by polymerase chain reaction revealed a complete mutation of the FMR 2 gene. This report stresses the importance of clinicians being aware of the association between a full mutation of FMR2 and ASD associated with compulsive behavior despite normal intellectual level. En ligne : http://dx.doi.org/10.1007/s10803-014-2185-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Autism spectrum disorder in sub-saharan africa: A comprehensive scoping review / Lauren FRANZ in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.723-749 Titre : Autism spectrum disorder in sub-saharan africa: A comprehensive scoping review Type de document : Texte imprimé et/ou numérique Auteurs : Lauren FRANZ, Auteur ; Nola J. CHAMBERS, Auteur ; Megan VON ISENBURG, Auteur ; Petrus J. DE VRIES, Auteur Article en page(s) : p.723-749 Langues : Anglais (eng) Mots-clés : autism  autism spectrum disorder  low- and middle-income countries  LMIC  low resource environments  Africa Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is recognized as a global public health concern, yet almost everything we know about ASD comes from high-income countries. Here we performed a scoping review of all research on ASD ever published in sub-Saharan Africa (SSA) in order to identify ASD knowledge gaps in this part of the world. Fifty-three publications met inclusion criteria. Themes included the phenotype, genetics and risk factors for ASD in SSA, screening and diagnosis, professional knowledge, interventions for ASD, parental perceptions, and social-cognitive neuroscience. No epidemiological, early intervention, school-based or adult studies were identified. For each identified theme, we aimed to summarize results and make recommendations to fill the knowledge gaps. The quality of study methodologies was generally not high. Few studies used standardized diagnostic instruments, and intervention studies were typically small-scale. Overall, findings suggest a substantial need for large-scale clinical, training, and research programmes to improve the lives of people who live with ASD in SSA. However, SSA also has the potential to make unique and globally-significant contributions to the etiology and treatments of ASD through implementation, interventional, and comparative genomic science. En ligne : http://dx.doi.org/10.1002/aur.1766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Autism spectrum disorder in sub-saharan africa: A comprehensive scoping review [Texte imprimé et/ou numérique] / Lauren FRANZ, Auteur ; Nola J. CHAMBERS, Auteur ; Megan VON ISENBURG, Auteur ; Petrus J. DE VRIES, Auteur . - p.723-749. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.723-749 Mots-clés : autism  autism spectrum disorder  low- and middle-income countries  LMIC  low resource environments  Africa Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is recognized as a global public health concern, yet almost everything we know about ASD comes from high-income countries. Here we performed a scoping review of all research on ASD ever published in sub-Saharan Africa (SSA) in order to identify ASD knowledge gaps in this part of the world. Fifty-three publications met inclusion criteria. Themes included the phenotype, genetics and risk factors for ASD in SSA, screening and diagnosis, professional knowledge, interventions for ASD, parental perceptions, and social-cognitive neuroscience. No epidemiological, early intervention, school-based or adult studies were identified. For each identified theme, we aimed to summarize results and make recommendations to fill the knowledge gaps. The quality of study methodologies was generally not high. Few studies used standardized diagnostic instruments, and intervention studies were typically small-scale. Overall, findings suggest a substantial need for large-scale clinical, training, and research programmes to improve the lives of people who live with ASD in SSA. However, SSA also has the potential to make unique and globally-significant contributions to the etiology and treatments of ASD through implementation, interventional, and comparative genomic science. En ligne : http://dx.doi.org/10.1002/aur.1766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment / Tonje TORSKE in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.207-220 Titre : Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment Type de document : Texte imprimé et/ou numérique Auteurs : Tonje TORSKE, Auteur ; Terje NAERLAND, Auteur ; Francesco BETTELLA, Auteur ; Thomas BJELLA, Auteur ; Eva MALT, Auteur ; Anne Lise HOYLAND, Auteur ; Nina STENBERG, Auteur ; Merete Glenne OIE, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : p.207-220 Langues : Anglais (eng) Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  behavior rating inventory of executive function  executive function  polygenic score Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally defined disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deficit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5-22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a significant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen's d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, significantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R(2) = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a significant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2020, 13: 207-220. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism spectrum disorder (ASD) often have difficulties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difficulties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems. En ligne : http://dx.doi.org/10.1002/aur.2207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment [Texte imprimé et/ou numérique] / Tonje TORSKE, Auteur ; Terje NAERLAND, Auteur ; Francesco BETTELLA, Auteur ; Thomas BJELLA, Auteur ; Eva MALT, Auteur ; Anne Lise HOYLAND, Auteur ; Nina STENBERG, Auteur ; Merete Glenne OIE, Auteur ; Ole A. ANDREASSEN, Auteur . - p.207-220. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.207-220 Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  behavior rating inventory of executive function  executive function  polygenic score Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally defined disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deficit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5-22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a significant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen's d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, significantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R(2) = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a significant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2020, 13: 207-220. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism spectrum disorder (ASD) often have difficulties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difficulties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems. En ligne : http://dx.doi.org/10.1002/aur.2207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Autism Spectrum Disorder Alertness in Dutch Youth and Family Center Physicians: Effects of a Live Online Educational Program / M. VAN 'T HOF in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3401-3411 Titre : Autism Spectrum Disorder Alertness in Dutch Youth and Family Center Physicians: Effects of a Live Online Educational Program Type de document : Texte imprimé et/ou numérique Auteurs : M. VAN 'T HOF, Auteur ; A. D. Y. VAN NIEUWENHUYZEN, Auteur ; I. VAN BERCKELAER-ONNES, Auteur ; M. DEEN, Auteur ; H. W. HOEK, Auteur ; W. A. ESTER, Auteur Article en page(s) : p.3401-3411 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnosis  Child  Ethnicity  Humans  Mass Screening  Physicians  Referral and Consultation  Autism spectrum disorder  Educational program  Preventive care physicians  Screening Index. décimale : PER Périodiques Résumé : We investigated the effect of a live online educational program in 93 Dutch Youth and Family Center (YFC) physicians who were screening for Autism Spectrum Disorder (ASD) in the general child population. The educational program raised the physicians' level of specific ASD knowledge and it remained higher at six months follow-up (p? En ligne : http://dx.doi.org/10.1007/s10803-020-04842-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Autism Spectrum Disorder Alertness in Dutch Youth and Family Center Physicians: Effects of a Live Online Educational Program [Texte imprimé et/ou numérique] / M. VAN 'T HOF, Auteur ; A. D. Y. VAN NIEUWENHUYZEN, Auteur ; I. VAN BERCKELAER-ONNES, Auteur ; M. DEEN, Auteur ; H. W. HOEK, Auteur ; W. A. ESTER, Auteur . - p.3401-3411. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3401-3411 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnosis  Child  Ethnicity  Humans  Mass Screening  Physicians  Referral and Consultation  Autism spectrum disorder  Educational program  Preventive care physicians  Screening Index. décimale : PER Périodiques Résumé : We investigated the effect of a live online educational program in 93 Dutch Youth and Family Center (YFC) physicians who were screening for Autism Spectrum Disorder (ASD) in the general child population. The educational program raised the physicians' level of specific ASD knowledge and it remained higher at six months follow-up (p? En ligne : http://dx.doi.org/10.1007/s10803-020-04842-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function / Eleni A. DEMETRIOU in Autism, 25-8 (November 2021)  

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Autism Spectrum Disorder and Genetic Testing: Parents' Attitudes-Data from Turkish Sample / A. B. AYHAN in Journal of Autism and Developmental Disorders, 51-9 (September 2021)  

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Autism spectrum disorder and obstetric optimality: a twin study and meta-analysis of sibling studies / S. GÓMEZ-VALLEJO in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

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Autism spectrum disorder prevalence and associated sociodemographic factors in the school population: EPINED study / Paula MORALES-HIDALGO in Autism, 25-7 (October 2021)  

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Autism spectrum disorder prevalence and associated sociodemographic factors in the school population: EPINED study / Paula MORALES-HIDALGO in Autism, 26-7 (October 2022)  

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