Children with very early onset obsessive-compulsive disorder: clinical features and treatment outcome / Eriko NAKATANI in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1261-1268 Titre : Children with very early onset obsessive-compulsive disorder: clinical features and treatment outcome Type de document : Texte imprimé et/ou numérique Auteurs : Eriko NAKATANI, Auteur ; Georgina KREBS, Auteur ; Nadia MICALI, Auteur ; Cynthia TURNER, Auteur ; Isobel HEYMAN, Auteur ; David MATAIX-COLS, Auteur Année de publication : 2011 Article en page(s) : p.1261-1268 Note générale : Obsessive-compulsive disorder; paediatric; age at onset; early onset; cognitive behaviour therapy Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background:  There is emerging evidence that early onset obsessive-compulsive disorder (OCD) may be a phenomenologically distinct subtype of the disorder. Previous research has shown that individuals who report an early onset display greater severity and persistence of symptoms, and they may be less responsive to treatment. To date, this question has been investigated solely in adult samples. The present study represents the first investigation into the effect of age at onset of OCD on clinical characteristics and response to treatment in a paediatric sample. Method:  A total of 365 young people referred to a specialist OCD clinic were included in the study. Clinical records were used to examine potential differences in key clinical characteristics between those who had a very early onset of the disorder (before 10 years) and those who had a late onset (10 years or later). Group differences in treatment responsiveness were also examined within a subgroup that received cognitive behaviour therapy (CBT) alone or CBT plus medication (n = 109). Results:  The very early onset group were characterised by a longer duration of illness, higher rates of comorbid tics, more frequent ordering and repeating compulsions and greater parent-reported psychosocial difficulties. There were no differences in treatment response between the groups, and when age at onset was examined as a continuous variable, it did not correlate with treatment response. Conclusions:  Very early onset OCD may be associated with different symptoms and comorbidities compared with late onset OCD. However, these differences do not appear to impact on responsiveness to developmentally tailored CBT alone or in combination with medication. These findings further indicate the value in early detection and treatment of OCD in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02434.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Children with very early onset obsessive-compulsive disorder: clinical features and treatment outcome [Texte imprimé et/ou numérique] / Eriko NAKATANI, Auteur ; Georgina KREBS, Auteur ; Nadia MICALI, Auteur ; Cynthia TURNER, Auteur ; Isobel HEYMAN, Auteur ; David MATAIX-COLS, Auteur . - 2011 . - p.1261-1268. Obsessive-compulsive disorder; paediatric; age at onset; early onset; cognitive behaviour therapy Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1261-1268 Index. décimale : PER Périodiques Résumé : Background:  There is emerging evidence that early onset obsessive-compulsive disorder (OCD) may be a phenomenologically distinct subtype of the disorder. Previous research has shown that individuals who report an early onset display greater severity and persistence of symptoms, and they may be less responsive to treatment. To date, this question has been investigated solely in adult samples. The present study represents the first investigation into the effect of age at onset of OCD on clinical characteristics and response to treatment in a paediatric sample. Method:  A total of 365 young people referred to a specialist OCD clinic were included in the study. Clinical records were used to examine potential differences in key clinical characteristics between those who had a very early onset of the disorder (before 10 years) and those who had a late onset (10 years or later). Group differences in treatment responsiveness were also examined within a subgroup that received cognitive behaviour therapy (CBT) alone or CBT plus medication (n = 109). Results:  The very early onset group were characterised by a longer duration of illness, higher rates of comorbid tics, more frequent ordering and repeating compulsions and greater parent-reported psychosocial difficulties. There were no differences in treatment response between the groups, and when age at onset was examined as a continuous variable, it did not correlate with treatment response. Conclusions:  Very early onset OCD may be associated with different symptoms and comorbidities compared with late onset OCD. However, these differences do not appear to impact on responsiveness to developmentally tailored CBT alone or in combination with medication. These findings further indicate the value in early detection and treatment of OCD in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02434.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

Temper outbursts in paediatric obsessive-compulsive disorder and their association with depressed mood and treatment outcome / Koen BOLHUIS ; Isobel HEYMAN ; David MATAIX-COLS ; Cynthia TURNER ; Argyris STRINGARIS in Journal of Child Psychology and Psychiatry, 54-3 (March 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.313-322 Titre : Temper outbursts in paediatric obsessive-compulsive disorder and their association with depressed mood and treatment outcome Type de document : Texte imprimé et/ou numérique Auteurs : Koen BOLHUIS, Auteur ; Isobel HEYMAN, Auteur ; David MATAIX-COLS, Auteur ; Cynthia TURNER, Auteur ; Argyris STRINGARIS, Auteur Article en page(s) : p.313-322 Mots-clés : Obsessive-compulsive disorder  paediatric  depression  disruptive behaviour  cognitive behaviour therapy Index. décimale : PER Périodiques Résumé : Background: Temper outbursts in youth with obsessive-compulsive disorder (OCD) are a common source of concern, but remain poorly understood. This study examined a set of hypotheses related to: (a) the prevalence of temper outbursts in paediatric OCD, (b) the associations of temper outbursts with OCD severity and depressive symptoms; and (c) the influence of temper outbursts on treatment response. Methods: The prevalence of temper outbursts was estimated in a specialist OCD clinical sample (n = 387) using parent- and child-report. This was replicated in a community sample (n = 18,415). Associations of temper outbursts with obsessive-compulsive symptoms and with depressed mood were examined using logistic regression models. The influence of temper outbursts on treatment response was examined in a subsample of 109 patients treated with cognitive behaviour therapy (CBT) with or without medication. Results: Over a third of young people with OCD displayed temper outbursts, and rates were similar across the clinical and community samples. Temper outbursts were two to three times more common in youth with OCD than in healthy controls. However, OCD symptom severity was not a strong predictor of child- or parent-reported temper outbursts. Instead, both child- and parent- reported temper outbursts were significantly associated to depressive symptoms. CBT strongly reduced OCD and depressive symptoms, as well as the severity of temper outbursts. There was no significant difference in post-treatment OCD or depression scores between those with temper outbursts compared to those without. Conclusions: Temper outbursts are common in youth with OCD and are particularly related to depressed mood. They improve with CBT for OCD and do not seem to impede OCD treatment response. AU - KREBS, Georgina En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02605.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191 [article] Temper outbursts in paediatric obsessive-compulsive disorder and their association with depressed mood and treatment outcome [Texte imprimé et/ou numérique] / Koen BOLHUIS, Auteur ; Isobel HEYMAN, Auteur ; David MATAIX-COLS, Auteur ; Cynthia TURNER, Auteur ; Argyris STRINGARIS, Auteur . - p.313-322. in Journal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.313-322 Mots-clés : Obsessive-compulsive disorder  paediatric  depression  disruptive behaviour  cognitive behaviour therapy Index. décimale : PER Périodiques Résumé : Background: Temper outbursts in youth with obsessive-compulsive disorder (OCD) are a common source of concern, but remain poorly understood. This study examined a set of hypotheses related to: (a) the prevalence of temper outbursts in paediatric OCD, (b) the associations of temper outbursts with OCD severity and depressive symptoms; and (c) the influence of temper outbursts on treatment response. Methods: The prevalence of temper outbursts was estimated in a specialist OCD clinical sample (n = 387) using parent- and child-report. This was replicated in a community sample (n = 18,415). Associations of temper outbursts with obsessive-compulsive symptoms and with depressed mood were examined using logistic regression models. The influence of temper outbursts on treatment response was examined in a subsample of 109 patients treated with cognitive behaviour therapy (CBT) with or without medication. Results: Over a third of young people with OCD displayed temper outbursts, and rates were similar across the clinical and community samples. Temper outbursts were two to three times more common in youth with OCD than in healthy controls. However, OCD symptom severity was not a strong predictor of child- or parent-reported temper outbursts. Instead, both child- and parent- reported temper outbursts were significantly associated to depressive symptoms. CBT strongly reduced OCD and depressive symptoms, as well as the severity of temper outbursts. There was no significant difference in post-treatment OCD or depression scores between those with temper outbursts compared to those without. Conclusions: Temper outbursts are common in youth with OCD and are particularly related to depressed mood. They improve with CBT for OCD and do not seem to impede OCD treatment response. AU - KREBS, Georgina En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02605.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191

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