Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population / Philip R. JANSEN in Journal of Child Psychology and Psychiatry, 59-1 (January 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.39-47 Titre : Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Philip R. JANSEN, Auteur ; Tinca J. C. POLDERMAN, Auteur ; Koen BOLHUIS, Auteur ; Jan VAN DER ENDE, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Tonya WHITE, Auteur ; Daniëlle POSTHUMA, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.39-47 Langues : Anglais (eng) Mots-clés : Polygenic scores  psychiatric disorders  educational attainment  childhood behaviour Index. décimale : PER Périodiques Résumé : Background Genome-wide association studies in adults have identified numerous genetic variants related to psychiatric disorders and related traits, such as schizophrenia and educational attainment. However, the effects of these genetic variants on behaviour in the general population remain to be fully understood, particularly in younger populations. We investigated whether polygenic scores of five psychiatric disorders and educational attainment are related to emotional and behaviour problems during early childhood. Methods From the Generation R Study, we included participants with available genotype data and behavioural problems measured with the Child Behavior Checklist (CBCL) at the age of 3 (n = 1,902), 6 (n = 2,202) and 10 years old (n = 1,843). Polygenic scores were calculated for five psychiatric disorders and educational attainment. These polygenic scores were tested for an association with the broadband internalizing and externalizing problem scales and the specific CBCL syndrome scale scores. Results Analysis of the CBCL broadband scales showed that the schizophrenia polygenic score was associated with significantly higher internalizing scores at 3, 6 and 10 years and higher externalizing scores at age 3 and 6. The educational attainment polygenic score was associated with lower externalizing scores at all time points and lower internalizing scores at age 3. No associations were observed for the polygenic scores of bipolar disorder, major depressive disorder and autism spectrum disorder. Secondary analyses of specific syndrome scores showed that the schizophrenia polygenic score was strongly related to the Thought Problems scores. A negative association was observed between the educational attainment polygenic score and Attention Problems scores across all age groups. Conclusions Polygenic scores for adult psychiatric disorders and educational attainment are associated with variation in emotional and behavioural problems already at a very early age. En ligne : http://dx.doi.org/10.1111/jcpp.12759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 [article] Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population [Texte imprimé et/ou numérique] / Philip R. JANSEN, Auteur ; Tinca J. C. POLDERMAN, Auteur ; Koen BOLHUIS, Auteur ; Jan VAN DER ENDE, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Tonya WHITE, Auteur ; Daniëlle POSTHUMA, Auteur ; Henning TIEMEIER, Auteur . - p.39-47. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.39-47 Mots-clés : Polygenic scores  psychiatric disorders  educational attainment  childhood behaviour Index. décimale : PER Périodiques Résumé : Background Genome-wide association studies in adults have identified numerous genetic variants related to psychiatric disorders and related traits, such as schizophrenia and educational attainment. However, the effects of these genetic variants on behaviour in the general population remain to be fully understood, particularly in younger populations. We investigated whether polygenic scores of five psychiatric disorders and educational attainment are related to emotional and behaviour problems during early childhood. Methods From the Generation R Study, we included participants with available genotype data and behavioural problems measured with the Child Behavior Checklist (CBCL) at the age of 3 (n = 1,902), 6 (n = 2,202) and 10 years old (n = 1,843). Polygenic scores were calculated for five psychiatric disorders and educational attainment. These polygenic scores were tested for an association with the broadband internalizing and externalizing problem scales and the specific CBCL syndrome scale scores. Results Analysis of the CBCL broadband scales showed that the schizophrenia polygenic score was associated with significantly higher internalizing scores at 3, 6 and 10 years and higher externalizing scores at age 3 and 6. The educational attainment polygenic score was associated with lower externalizing scores at all time points and lower internalizing scores at age 3. No associations were observed for the polygenic scores of bipolar disorder, major depressive disorder and autism spectrum disorder. Secondary analyses of specific syndrome scores showed that the schizophrenia polygenic score was strongly related to the Thought Problems scores. A negative association was observed between the educational attainment polygenic score and Attention Problems scores across all age groups. Conclusions Polygenic scores for adult psychiatric disorders and educational attainment are associated with variation in emotional and behavioural problems already at a very early age. En ligne : http://dx.doi.org/10.1111/jcpp.12759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327

Psychotic experiences and future school performance in childhood: a population-based cohort study / Lisa R STEENKAMP in Journal of Child Psychology and Psychiatry, 62-3 (March 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.357-365 Titre : Psychotic experiences and future school performance in childhood: a population-based cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Lisa R STEENKAMP, Auteur ; Koen BOLHUIS, Auteur ; Laura M. E. BLANKEN, Auteur ; Maartje P. C. M. LUIJK, Auteur ; Manon H. J. HILLEGERS, Auteur ; Steven A. KUSHNER, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.357-365 Langues : Anglais (eng) Mots-clés : Psychosis  cognitive impairment  intelligence  school children  school performance Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychotic experiences are common in childhood and an important risk indicator of adverse mental health outcomes. However, little is known about the association of psychotic experiences with functional outcomes in childhood, particularly regarding school performance. The aim of the present study was to examine whether psychotic experiences were prospectively related to school performance in childhood. METHODS: This study was embedded in the population-based Generation R Study (N = 2,362). Psychotic experiences were assessed using self-reports on hallucinations at age 10 years. School performance was assessed using a standardized national school performance test at age 12 years. We considered the total school performance score, as well as language and mathematics subscales. Analyses were adjusted for sociodemographic characteristics, maternal nonverbal IQ, nonverbal IQ at age 6 years and co-occurring psychopathology at age 10 years. RESULTS: Psychotic experiences were prospectively associated with poorer school performance scores (B = -0.61, 95% CI [-0.98;-0.25], p = .001), as well as poorer language (B(percentile rank score)  = -2.00, 95% CI [-3.20;-0.79], p = .001) and mathematical ability (B(percentile rank score)  = -1.75, 95% CI [-2.99;-0.51], p = .006). These associations remained after additional adjustment for nonverbal IQ at age 6 years (B = -0.51, 95% CI [-0.86;-0.16], p = .005), and co-occurring internalizing (B = -0.40, 95% CI [-0.77;-0.03], p = .036) and externalizing problems (B = -0.40, 95% CI [-0.75;-0.04], p = .029), but not attention problems (B = -0.10, 95% CI [-0.47;0.26], p = .57). CONCLUSIONS: Children with psychotic experiences had lower school performance scores than their nonaffected peers. The finding was independent of sociodemographic characteristics, intelligence and co-occurring internalizing and externalizing problems, but not attention problems. This study suggests that psychotic experiences are associated with childhood functional impairments, although the relatively small effects and the role of attention problems warrant further exploration. En ligne : http://dx.doi.org/10.1111/jcpp.13281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Psychotic experiences and future school performance in childhood: a population-based cohort study [Texte imprimé et/ou numérique] / Lisa R STEENKAMP, Auteur ; Koen BOLHUIS, Auteur ; Laura M. E. BLANKEN, Auteur ; Maartje P. C. M. LUIJK, Auteur ; Manon H. J. HILLEGERS, Auteur ; Steven A. KUSHNER, Auteur ; Henning TIEMEIER, Auteur . - p.357-365. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-3 (March 2021) . - p.357-365 Mots-clés : Psychosis  cognitive impairment  intelligence  school children  school performance Index. décimale : PER Périodiques Résumé : BACKGROUND: Psychotic experiences are common in childhood and an important risk indicator of adverse mental health outcomes. However, little is known about the association of psychotic experiences with functional outcomes in childhood, particularly regarding school performance. The aim of the present study was to examine whether psychotic experiences were prospectively related to school performance in childhood. METHODS: This study was embedded in the population-based Generation R Study (N = 2,362). Psychotic experiences were assessed using self-reports on hallucinations at age 10 years. School performance was assessed using a standardized national school performance test at age 12 years. We considered the total school performance score, as well as language and mathematics subscales. Analyses were adjusted for sociodemographic characteristics, maternal nonverbal IQ, nonverbal IQ at age 6 years and co-occurring psychopathology at age 10 years. RESULTS: Psychotic experiences were prospectively associated with poorer school performance scores (B = -0.61, 95% CI [-0.98;-0.25], p = .001), as well as poorer language (B(percentile rank score)  = -2.00, 95% CI [-3.20;-0.79], p = .001) and mathematical ability (B(percentile rank score)  = -1.75, 95% CI [-2.99;-0.51], p = .006). These associations remained after additional adjustment for nonverbal IQ at age 6 years (B = -0.51, 95% CI [-0.86;-0.16], p = .005), and co-occurring internalizing (B = -0.40, 95% CI [-0.77;-0.03], p = .036) and externalizing problems (B = -0.40, 95% CI [-0.75;-0.04], p = .029), but not attention problems (B = -0.10, 95% CI [-0.47;0.26], p = .57). CONCLUSIONS: Children with psychotic experiences had lower school performance scores than their nonaffected peers. The finding was independent of sociodemographic characteristics, intelligence and co-occurring internalizing and externalizing problems, but not attention problems. This study suggests that psychotic experiences are associated with childhood functional impairments, although the relatively small effects and the role of attention problems warrant further exploration. En ligne : http://dx.doi.org/10.1111/jcpp.13281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

Temper outbursts in paediatric obsessive-compulsive disorder and their association with depressed mood and treatment outcome / Koen BOLHUIS ; Isobel HEYMAN ; David MATAIX-COLS ; Cynthia TURNER ; Argyris STRINGARIS in Journal of Child Psychology and Psychiatry, 54-3 (March 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.313-322 Titre : Temper outbursts in paediatric obsessive-compulsive disorder and their association with depressed mood and treatment outcome Type de document : Texte imprimé et/ou numérique Auteurs : Koen BOLHUIS, Auteur ; Isobel HEYMAN, Auteur ; David MATAIX-COLS, Auteur ; Cynthia TURNER, Auteur ; Argyris STRINGARIS, Auteur Article en page(s) : p.313-322 Mots-clés : Obsessive-compulsive disorder  paediatric  depression  disruptive behaviour  cognitive behaviour therapy Index. décimale : PER Périodiques Résumé : Background: Temper outbursts in youth with obsessive-compulsive disorder (OCD) are a common source of concern, but remain poorly understood. This study examined a set of hypotheses related to: (a) the prevalence of temper outbursts in paediatric OCD, (b) the associations of temper outbursts with OCD severity and depressive symptoms; and (c) the influence of temper outbursts on treatment response. Methods: The prevalence of temper outbursts was estimated in a specialist OCD clinical sample (n = 387) using parent- and child-report. This was replicated in a community sample (n = 18,415). Associations of temper outbursts with obsessive-compulsive symptoms and with depressed mood were examined using logistic regression models. The influence of temper outbursts on treatment response was examined in a subsample of 109 patients treated with cognitive behaviour therapy (CBT) with or without medication. Results: Over a third of young people with OCD displayed temper outbursts, and rates were similar across the clinical and community samples. Temper outbursts were two to three times more common in youth with OCD than in healthy controls. However, OCD symptom severity was not a strong predictor of child- or parent-reported temper outbursts. Instead, both child- and parent- reported temper outbursts were significantly associated to depressive symptoms. CBT strongly reduced OCD and depressive symptoms, as well as the severity of temper outbursts. There was no significant difference in post-treatment OCD or depression scores between those with temper outbursts compared to those without. Conclusions: Temper outbursts are common in youth with OCD and are particularly related to depressed mood. They improve with CBT for OCD and do not seem to impede OCD treatment response. AU - KREBS, Georgina En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02605.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191 [article] Temper outbursts in paediatric obsessive-compulsive disorder and their association with depressed mood and treatment outcome [Texte imprimé et/ou numérique] / Koen BOLHUIS, Auteur ; Isobel HEYMAN, Auteur ; David MATAIX-COLS, Auteur ; Cynthia TURNER, Auteur ; Argyris STRINGARIS, Auteur . - p.313-322. in Journal of Child Psychology and Psychiatry > 54-3 (March 2013) . - p.313-322 Mots-clés : Obsessive-compulsive disorder  paediatric  depression  disruptive behaviour  cognitive behaviour therapy Index. décimale : PER Périodiques Résumé : Background: Temper outbursts in youth with obsessive-compulsive disorder (OCD) are a common source of concern, but remain poorly understood. This study examined a set of hypotheses related to: (a) the prevalence of temper outbursts in paediatric OCD, (b) the associations of temper outbursts with OCD severity and depressive symptoms; and (c) the influence of temper outbursts on treatment response. Methods: The prevalence of temper outbursts was estimated in a specialist OCD clinical sample (n = 387) using parent- and child-report. This was replicated in a community sample (n = 18,415). Associations of temper outbursts with obsessive-compulsive symptoms and with depressed mood were examined using logistic regression models. The influence of temper outbursts on treatment response was examined in a subsample of 109 patients treated with cognitive behaviour therapy (CBT) with or without medication. Results: Over a third of young people with OCD displayed temper outbursts, and rates were similar across the clinical and community samples. Temper outbursts were two to three times more common in youth with OCD than in healthy controls. However, OCD symptom severity was not a strong predictor of child- or parent-reported temper outbursts. Instead, both child- and parent- reported temper outbursts were significantly associated to depressive symptoms. CBT strongly reduced OCD and depressive symptoms, as well as the severity of temper outbursts. There was no significant difference in post-treatment OCD or depression scores between those with temper outbursts compared to those without. Conclusions: Temper outbursts are common in youth with OCD and are particularly related to depressed mood. They improve with CBT for OCD and do not seem to impede OCD treatment response. AU - KREBS, Georgina En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02605.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=191

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