ental and behavioral symptoms of person's with Asperger's syndrome: Relationships with social isolation and handicaps / Masayuki TANI in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.907-912 Titre : ental and behavioral symptoms of person's with Asperger's syndrome: Relationships with social isolation and handicaps Type de document : Texte imprimé et/ou numérique Auteurs : Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Haruhisa OTA, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Hideki YOKOI, Auteur ; Yuko TAKAYAMA, Auteur ; Taisei ONO, Auteur ; Ryuichiro HASHIMORO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur Année de publication : 2012 Article en page(s) : p.907-912 Langues : Anglais (eng) Mots-clés : Asperger's syndrome  Mental symptoms  Behavioral symptoms  Life history Index. décimale : PER Périodiques Résumé : People with Asperger's syndrome (AS) experience mental comorbidities, and behavioral symptoms that can deepen social isolation and handicaps. We compared the frequency of mental and behavioral symptoms, motor abnormality, and life history between adults with AS and those with no mental disorders but with disturbance of social functions and communication skills (ND) from our outpatient clinic. Participants with AS (n = 99) as compared with ND subjects (n = 63) showed significant higher rate of depressive mood, anxiety, unstable emotion, mood swings, oversensitivity to normal situation obsessive compulsive symptoms, persecutory idea, loss of energy, insomnia carelessness, restlessness, confusion in new environments, episodic agitation, inflexible adherence, egocentric behavior, self harm, circumscribed interest, poor lifestyle habits, non-athleticism, clumsiness, bulling at school, school non-attendance, social withdrawal, and lack of friendships. In AS, emotional instability and confusion in new environments might lead to social isolation. The findings demonstrated that individuals with AS experience greater social isolation and distress, as well as a wider range of mental and behavioral symptoms and disturbances of motor skills as compared to healthy subjects with disturbances of social functions and communication skills. These factors are interrelated and may be used as supplementary methods for differential diagnosis of AS from other conditions. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] ental and behavioral symptoms of person's with Asperger's syndrome: Relationships with social isolation and handicaps [Texte imprimé et/ou numérique] / Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Haruhisa OTA, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Hideki YOKOI, Auteur ; Yuko TAKAYAMA, Auteur ; Taisei ONO, Auteur ; Ryuichiro HASHIMORO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur . - 2012 . - p.907-912. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.907-912 Mots-clés : Asperger's syndrome  Mental symptoms  Behavioral symptoms  Life history Index. décimale : PER Périodiques Résumé : People with Asperger's syndrome (AS) experience mental comorbidities, and behavioral symptoms that can deepen social isolation and handicaps. We compared the frequency of mental and behavioral symptoms, motor abnormality, and life history between adults with AS and those with no mental disorders but with disturbance of social functions and communication skills (ND) from our outpatient clinic. Participants with AS (n = 99) as compared with ND subjects (n = 63) showed significant higher rate of depressive mood, anxiety, unstable emotion, mood swings, oversensitivity to normal situation obsessive compulsive symptoms, persecutory idea, loss of energy, insomnia carelessness, restlessness, confusion in new environments, episodic agitation, inflexible adherence, egocentric behavior, self harm, circumscribed interest, poor lifestyle habits, non-athleticism, clumsiness, bulling at school, school non-attendance, social withdrawal, and lack of friendships. In AS, emotional instability and confusion in new environments might lead to social isolation. The findings demonstrated that individuals with AS experience greater social isolation and distress, as well as a wider range of mental and behavioral symptoms and disturbances of motor skills as compared to healthy subjects with disturbances of social functions and communication skills. These factors are interrelated and may be used as supplementary methods for differential diagnosis of AS from other conditions. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.12.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) / Yuko TAKAYAMA in Research in Autism Spectrum Disorders, 8-4 (April 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-4 (April 2014) . - p.347-353 Titre : Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) Type de document : Texte imprimé et/ou numérique Auteurs : Yuko TAKAYAMA, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Taisei ONO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur Article en page(s) : p.347-353 Mots-clés : Autism spectrum disorders  Sensory sensitivity  Glasgow Sensory Questionnaire  Autism spectrum quotient Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) often have sensory processing abnormalities. However, limited measures that assess these problems in adults with ASD have been developed till date, particularly in Japan. Robertson and Simmons (2012) developed a self-rating scale to investigate sensory sensitivity: the Glasgow Sensory Questionnaire (GSQ). In the present study, we developed a Japanese version of GSQ and investigated sensory abnormalities in adults with ASD. We compared results of the Japanese version of GSQ in adults between an ASD group (n = 64) and a control group (n = 70). In addition, we also administered these individuals with the autism spectrum quotient (AQ), which is a questionnaire for assessing autistic traits. The Japanese version of GSQ scores was significantly higher in the ASD group than that in the control group. The total GSQ score and each sensory subscale showed a positive correlation with AQ in the total study sample. These results indicate that individuals with pronounced autistic traits have more frequent and extreme sensory processing problems compared with that in individuals with less pronounced autistic traits. We also assessed validity of the new test. Cronbach's ? of the questionnaire was calculated, and its high value indicates that the Japanese version of GSQ has high reliability. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226 [article] Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) [Texte imprimé et/ou numérique] / Yuko TAKAYAMA, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Taisei ONO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur . - p.347-353. in Research in Autism Spectrum Disorders > 8-4 (April 2014) . - p.347-353 Mots-clés : Autism spectrum disorders  Sensory sensitivity  Glasgow Sensory Questionnaire  Autism spectrum quotient Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) often have sensory processing abnormalities. However, limited measures that assess these problems in adults with ASD have been developed till date, particularly in Japan. Robertson and Simmons (2012) developed a self-rating scale to investigate sensory sensitivity: the Glasgow Sensory Questionnaire (GSQ). In the present study, we developed a Japanese version of GSQ and investigated sensory abnormalities in adults with ASD. We compared results of the Japanese version of GSQ in adults between an ASD group (n = 64) and a control group (n = 70). In addition, we also administered these individuals with the autism spectrum quotient (AQ), which is a questionnaire for assessing autistic traits. The Japanese version of GSQ scores was significantly higher in the ASD group than that in the control group. The total GSQ score and each sensory subscale showed a positive correlation with AQ in the total study sample. These results indicate that individuals with pronounced autistic traits have more frequent and extreme sensory processing problems compared with that in individuals with less pronounced autistic traits. We also assessed validity of the new test. Cronbach's ? of the questionnaire was calculated, and its high value indicates that the Japanese version of GSQ has high reliability. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226

The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study / I-Fan LIN in Molecular Autism, (February 2014)  

Public ISBD [article]  inMolecular Autism > (February 2014) Titre : The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study Type de document : Texte imprimé et/ou numérique Auteurs : I-Fan LIN, Auteur ; Makio KASHINO, Auteur ; Haruhisa OHTA, Auteur ; Takashi YAMADA, Auteur ; Masayuki TANI, Auteur ; Hiromi WATANABE, Auteur ; Chieko KANAI, Auteur ; Taisei OHNO, Auteur ; Yuko TAKAYAMA, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorders (ASD) have difficulty with verbal communication, which might be due to a lack of spontaneous orientation toward social auditory stimuli. Previous studies have shown that a single dose of oxytocin improves speech comprehension in autism. The primary aim of this study was to investigate whether the orientation behaviors toward human sounds are different for neurotypical (NT) adults and adults with ASD and whether oxytocin has an effect on their orientation behaviors toward human sounds. This was a randomized, placebo-controlled, within-subject, crossover design study of intranasal oxytocin versus placebo in 13 NT adults and 16 adults with ASD. Subjects were randomized to 24 IU intranasal oxytocin or placebo on different days, and they were blind to the treatment. The participants then listened passively to human and non-human affective sounds while their skin conductance responses (SCRs) and the changes in peripheral blood vessel constriction were monitored as an indicator of spontaneous orientation. The monitored data were analyzed by a mixed-design ANOVA. Oxytocin enhanced the difference between the SCRs to human and non-human sounds in both the NT and ASD groups (F(1,56) = 6.046, p = 0.017). Further correlation coefficient analysis showed significant correlations between this SCR difference and the scores in the autism spectrum quotient 'attention to detail' and 'social skill' subscales and interpersonal reactivity index and social functioning scale in the ASD group. Oxytocin was well tolerated, and no serious adverse effects were reported. The difference in SCRs implies that oxytocin nasal spray may enhance orientation behaviors toward human sounds in the presence of other environmental sounds in both ASD and NT adults.Trial registration: UMIN-CTR Clinical Trial, Unique trial number: UMIN000005809 En ligne : http://dx.doi.org/10.1186/2040-2392-5-20 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study [Texte imprimé et/ou numérique] / I-Fan LIN, Auteur ; Makio KASHINO, Auteur ; Haruhisa OHTA, Auteur ; Takashi YAMADA, Auteur ; Masayuki TANI, Auteur ; Hiromi WATANABE, Auteur ; Chieko KANAI, Auteur ; Taisei OHNO, Auteur ; Yuko TAKAYAMA, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur. Langues : Anglais (eng) in Molecular Autism > (February 2014) Index. décimale : PER Périodiques Résumé : Many individuals with autism spectrum disorders (ASD) have difficulty with verbal communication, which might be due to a lack of spontaneous orientation toward social auditory stimuli. Previous studies have shown that a single dose of oxytocin improves speech comprehension in autism. The primary aim of this study was to investigate whether the orientation behaviors toward human sounds are different for neurotypical (NT) adults and adults with ASD and whether oxytocin has an effect on their orientation behaviors toward human sounds. This was a randomized, placebo-controlled, within-subject, crossover design study of intranasal oxytocin versus placebo in 13 NT adults and 16 adults with ASD. Subjects were randomized to 24 IU intranasal oxytocin or placebo on different days, and they were blind to the treatment. The participants then listened passively to human and non-human affective sounds while their skin conductance responses (SCRs) and the changes in peripheral blood vessel constriction were monitored as an indicator of spontaneous orientation. The monitored data were analyzed by a mixed-design ANOVA. Oxytocin enhanced the difference between the SCRs to human and non-human sounds in both the NT and ASD groups (F(1,56) = 6.046, p = 0.017). Further correlation coefficient analysis showed significant correlations between this SCR difference and the scores in the autism spectrum quotient 'attention to detail' and 'social skill' subscales and interpersonal reactivity index and social functioning scale in the ASD group. Oxytocin was well tolerated, and no serious adverse effects were reported. The difference in SCRs implies that oxytocin nasal spray may enhance orientation behaviors toward human sounds in the presence of other environmental sounds in both ASD and NT adults.Trial registration: UMIN-CTR Clinical Trial, Unique trial number: UMIN000005809 En ligne : http://dx.doi.org/10.1186/2040-2392-5-20 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

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