Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder / Charity ONORE in Autism Research and Treatment, (December 2011)  

Public ISBD [article]  inAutism Research and Treatment > (December 2011) . - 4 p. Titre : Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Charity ONORE, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur Année de publication : 2011 Article en page(s) : 4 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the US, yet the pathology of this disorder is not fully understood. Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF) and hepatocyte growth factor (HGF). Both of these growth factors serve important roles in neurodevelopment and immune function. In this study, concentrations of EGF and HGF were assessed in the plasma of 49 children with ASD aged 2–4 years old and 31 typically developing controls of a similar age as part of the Autism Phenome Project (APP). Levels of EGF were significantly reduced in the ASD group compared to typically developing controls (P=0.003). There were no significant differences in HGF levels in young children with ASD and typically developing controls. EGF plays an important role in regulating neural growth, proliferation, differentiation, and migration, and reduced levels of this molecule may negatively impact neurodevelopment in young children with ASD. En ligne : http://dx.doi.org/10.1155/2012/205362 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Charity ONORE, Auteur ; Judy VAN DE WATER, Auteur ; Paul ASHWOOD, Auteur . - 2011 . - 4 p. Langues : Anglais (eng) in Autism Research and Treatment > (December 2011) . - 4 p. Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the US, yet the pathology of this disorder is not fully understood. Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF) and hepatocyte growth factor (HGF). Both of these growth factors serve important roles in neurodevelopment and immune function. In this study, concentrations of EGF and HGF were assessed in the plasma of 49 children with ASD aged 2–4 years old and 31 typically developing controls of a similar age as part of the Autism Phenome Project (APP). Levels of EGF were significantly reduced in the ASD group compared to typically developing controls (P=0.003). There were no significant differences in HGF levels in young children with ASD and typically developing controls. EGF plays an important role in regulating neural growth, proliferation, differentiation, and migration, and reduced levels of this molecule may negatively impact neurodevelopment in young children with ASD. En ligne : http://dx.doi.org/10.1155/2012/205362 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

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