[article]
| Titre : |
Sex-biased gene expression in the developing brain: implications for autism spectrum disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Mark ZIATS, Auteur ; Owen RENNERT, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
3 p. |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autistic disorder Gene expression Sex differences |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism spectrum disorders affect significantly more males than females. Understanding sex differences in normal human brain development may provide insight into the mechanism(s) underlying this disparity; however, studies of sex differences in brain development at the genomic level are lacking. Here, we report a re-analysis of sex-specific gene expression from a recent large transcriptomic study of normal human brain development, to determine whether sex-biased genes relate to specific mechanistic processes. We discovered that male-biased genes are enriched for the processes of extracellular matrix formation/glycoproteins, immune response, chromatin, and cell cytoskeleton. We highlight that these pathways have been repeatedly implicated in autism and demonstrate that autism candidate genes are also enriched for these pathways. We propose that the overlap of these male-specific brain transcriptional modules with the same pathways in autism spectrum disorders may partially explain the increased incidence of autism in males. |
| En ligne : |
http://dx.doi.org/10.1186/2040-2392-4-10 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 |
in Molecular Autism > (May 2013) . - 3 p.
[article] Sex-biased gene expression in the developing brain: implications for autism spectrum disorders [Texte imprimé et/ou numérique] / Mark ZIATS, Auteur ; Owen RENNERT, Auteur . - 2013 . - 3 p. Langues : Anglais ( eng) in Molecular Autism > (May 2013) . - 3 p.
| Mots-clés : |
Autistic disorder Gene expression Sex differences |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism spectrum disorders affect significantly more males than females. Understanding sex differences in normal human brain development may provide insight into the mechanism(s) underlying this disparity; however, studies of sex differences in brain development at the genomic level are lacking. Here, we report a re-analysis of sex-specific gene expression from a recent large transcriptomic study of normal human brain development, to determine whether sex-biased genes relate to specific mechanistic processes. We discovered that male-biased genes are enriched for the processes of extracellular matrix formation/glycoproteins, immune response, chromatin, and cell cytoskeleton. We highlight that these pathways have been repeatedly implicated in autism and demonstrate that autism candidate genes are also enriched for these pathways. We propose that the overlap of these male-specific brain transcriptional modules with the same pathways in autism spectrum disorders may partially explain the increased incidence of autism in males. |
| En ligne : |
http://dx.doi.org/10.1186/2040-2392-4-10 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 |
|
Sex-biased gene expression in the developing brain: implications for autism spectrum disorders in Molecular Autism, (May 2013)
