[article] 
inJournal of Autism and Developmental Disorders > 43-7 (July 2013) . - p.1505-1516

Titre :	Narrowly Versus Broadly Defined Autism Spectrum Disorders: Differences in Pre- and Perinatal Risk Factors
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Janne C. VISSER, Auteur ; Nanda N. ROMMELSE, Auteur ; Lianne VINK, Auteur ; Margo SCHRIEKEN, Auteur ; Iris J. OOSTERLING, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur
Année de publication :	2013
Article en page(s) :	p.1505-1516
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum disorders  Prenatal  Perinatal  Risk factor
Index. décimale :	PER Périodiques
Résumé :	This study examined the differential contribution of pre- and perinatal risks in narrowly versus broadly defined autism spectrum disorder (ASD) and across core symptom domains, IQ and co-morbid problems. Children with a DSM-IV diagnosis of autistic disorder (AD) (n = 121) or pervasive developmental disorder not otherwise specified (PDD-NOS) (n = 75) were compared to a typical control sample (n = 311). Diagnoses were based on extensive assessments between 12 and 49 months of age (M = 33.3, SD = 6.4) and re-evaluated at 43–98 months (M = 68.1, SD = 10.7) in 70 % of the cases. Compared with controls, cases with ASD were more likely to be firstborn and show a suboptimal condition after birth. Case mothers reported more infections and more stress during pregnancy. Although the ASD subgroups showed mostly overlapping risks, cases with PDD-NOS differed from those with AD by higher exposure to smoking during pregnancy (SDP) and by a negative association of smoking with IQ, regardless of confounders. SDP appears to contribute more to broadly defined (PDD-NOS) than to narrowly defined ASD (AD). Findings suggest differences in etiological contributors between ASD phenotypes.
En ligne :	http://dx.doi.org/10.1007/s10803-012-1678-6
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

[article] Narrowly Versus Broadly Defined Autism Spectrum Disorders: Differences in Pre- and Perinatal Risk Factors [Texte imprimé et/ou numérique] / Janne C. VISSER, Auteur ; Nanda N. ROMMELSE, Auteur ; Lianne VINK, Auteur ; Margo SCHRIEKEN, Auteur ; Iris J. OOSTERLING, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur . - 2013 . - p.1505-1516.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-7 (July 2013) . - p.1505-1516

Mots-clés :	Autism spectrum disorders  Prenatal  Perinatal  Risk factor
Index. décimale :	PER Périodiques
Résumé :	This study examined the differential contribution of pre- and perinatal risks in narrowly versus broadly defined autism spectrum disorder (ASD) and across core symptom domains, IQ and co-morbid problems. Children with a DSM-IV diagnosis of autistic disorder (AD) (n = 121) or pervasive developmental disorder not otherwise specified (PDD-NOS) (n = 75) were compared to a typical control sample (n = 311). Diagnoses were based on extensive assessments between 12 and 49 months of age (M = 33.3, SD = 6.4) and re-evaluated at 43–98 months (M = 68.1, SD = 10.7) in 70 % of the cases. Compared with controls, cases with ASD were more likely to be firstborn and show a suboptimal condition after birth. Case mothers reported more infections and more stress during pregnancy. Although the ASD subgroups showed mostly overlapping risks, cases with PDD-NOS differed from those with AD by higher exposure to smoking during pregnancy (SDP) and by a negative association of smoking with IQ, regardless of confounders. SDP appears to contribute more to broadly defined (PDD-NOS) than to narrowly defined ASD (AD). Findings suggest differences in etiological contributors between ASD phenotypes.
En ligne :	http://dx.doi.org/10.1007/s10803-012-1678-6
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202