Attention across modalities as a longitudinal predictor of early outcomes: the case of fragile X syndrome / Gaia SCERIF in Journal of Child Psychology and Psychiatry, 53-6 (June 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.641–650 Titre : Attention across modalities as a longitudinal predictor of early outcomes: the case of fragile X syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Gaia SCERIF, Auteur ; Elena LONGHI, Auteur ; Victoria COLE, Auteur ; Annette KARMILOFF-SMITH, Auteur ; Kim CORNISH, Auteur Année de publication : 2012 Article en page(s) : p.641–650 Langues : Anglais (eng) Mots-clés : Fragile X syndrome  attention deficits  longitudinal predictors of outcomes Index. décimale : PER Périodiques Résumé : Background:  Fragile X syndrome (FXS) is an early diagnosed monogenic disorder, associated with a striking pattern of cognitive/attentional difficulties and a high risk of poor behavioural outcomes. FXS therefore represents an ideal model disorder to study prospectively the impact of early attention deficits on behaviour. Methods:  Thirty-seven boys with FXS aged 4–10 years and 74 typically developing (TD) boys took part. Study 1 was designed to assess visual and auditory attention at two time-points, 1 year apart. Study 2 investigated attention to multimodal information. Both tested attention markers as longitudinal predictors of risk for poor behaviour in FXS. Results:  Children with FXS attended less well than mental-age matched TD boys and experienced greater difficulties with auditory compared to visual stimuli. In addition, unlike TD children, they did not benefit from multimodal information. Attention markers were significant predictors of later behavioural difficulties in boys with FXS. Conclusions:  Findings demonstrate, for the first time, greater difficulties with auditory attention and atypical processing of multimodal information, in addition to pervasive global attentional difficulties in boys with FXS. Attention predicted outcomes longitudinally, underscoring the need to dissect what drives differing developmental trajectories for individual children within a seemingly homogeneous group. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02515.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157 [article] Attention across modalities as a longitudinal predictor of early outcomes: the case of fragile X syndrome [Texte imprimé et/ou numérique] / Gaia SCERIF, Auteur ; Elena LONGHI, Auteur ; Victoria COLE, Auteur ; Annette KARMILOFF-SMITH, Auteur ; Kim CORNISH, Auteur . - 2012 . - p.641–650. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-6 (June 2012) . - p.641–650 Mots-clés : Fragile X syndrome  attention deficits  longitudinal predictors of outcomes Index. décimale : PER Périodiques Résumé : Background:  Fragile X syndrome (FXS) is an early diagnosed monogenic disorder, associated with a striking pattern of cognitive/attentional difficulties and a high risk of poor behavioural outcomes. FXS therefore represents an ideal model disorder to study prospectively the impact of early attention deficits on behaviour. Methods:  Thirty-seven boys with FXS aged 4–10 years and 74 typically developing (TD) boys took part. Study 1 was designed to assess visual and auditory attention at two time-points, 1 year apart. Study 2 investigated attention to multimodal information. Both tested attention markers as longitudinal predictors of risk for poor behaviour in FXS. Results:  Children with FXS attended less well than mental-age matched TD boys and experienced greater difficulties with auditory compared to visual stimuli. In addition, unlike TD children, they did not benefit from multimodal information. Attention markers were significant predictors of later behavioural difficulties in boys with FXS. Conclusions:  Findings demonstrate, for the first time, greater difficulties with auditory attention and atypical processing of multimodal information, in addition to pervasive global attentional difficulties in boys with FXS. Attention predicted outcomes longitudinally, underscoring the need to dissect what drives differing developmental trajectories for individual children within a seemingly homogeneous group. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02515.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=157

Mapping developmental trajectories of attention and working memory in fragile X syndrome: Developmental freeze or developmental change? / Kim CORNISH in Development and Psychopathology, 25-2 (May 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-2 (May 2013) . - p.365-376 Titre : Mapping developmental trajectories of attention and working memory in fragile X syndrome: Developmental freeze or developmental change? Type de document : Texte imprimé et/ou numérique Auteurs : Kim CORNISH, Auteur ; Victoria COLE, Auteur ; Elena LONGHI, Auteur ; Annette KARMILOFF-SMITH, Auteur ; Gaia SCERIF, Auteur Article en page(s) : p.365-376 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) has a characteristic cognitive “signature” that by late childhood includes core weaknesses in attention and working memory (WM), but their earlier developmental trajectories remain uncharted. Using a combined cross-sectional and prospective longitudinal design, we tested whether early profiles of attention and WM impairment in FXS indicate developmental freeze or developmental change. In Study 1, 26 young boys with FXS and 55 typically developing (TD) boys completed two experimental paradigms designed to assess cognitive aspects of attention and WM, in addition to behavioral indices of inattention and hyperactivity. Study 2 mapped longitudinal changes in 21 children with FXS and 21 TD children. In Study 1, significant weaknesses emerged for boys with FXS, with no substantial improvement over chronological age. Mapping performance against mental age level revealed delay, but it also yielded a similar attention and WM profile to TD boys. In Study 2, longitudinal improvements for boys with FXS paralleled those in TD children. In conclusion, cognitive attention and WM, although delayed in FXS, reveal developmental change, rather than “arrest.” Our findings underscore the need for going beyond cross-sectional group comparisons and gross behavioral indices to map cognitive changes longitudinally in developmental disorders. En ligne : http://dx.doi.org/10.1017/S0954579412001113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199 [article] Mapping developmental trajectories of attention and working memory in fragile X syndrome: Developmental freeze or developmental change? [Texte imprimé et/ou numérique] / Kim CORNISH, Auteur ; Victoria COLE, Auteur ; Elena LONGHI, Auteur ; Annette KARMILOFF-SMITH, Auteur ; Gaia SCERIF, Auteur . - p.365-376. Langues : Anglais (eng) in Development and Psychopathology > 25-2 (May 2013) . - p.365-376 Index. décimale : PER Périodiques Résumé : Fragile X syndrome (FXS) has a characteristic cognitive “signature” that by late childhood includes core weaknesses in attention and working memory (WM), but their earlier developmental trajectories remain uncharted. Using a combined cross-sectional and prospective longitudinal design, we tested whether early profiles of attention and WM impairment in FXS indicate developmental freeze or developmental change. In Study 1, 26 young boys with FXS and 55 typically developing (TD) boys completed two experimental paradigms designed to assess cognitive aspects of attention and WM, in addition to behavioral indices of inattention and hyperactivity. Study 2 mapped longitudinal changes in 21 children with FXS and 21 TD children. In Study 1, significant weaknesses emerged for boys with FXS, with no substantial improvement over chronological age. Mapping performance against mental age level revealed delay, but it also yielded a similar attention and WM profile to TD boys. In Study 2, longitudinal improvements for boys with FXS paralleled those in TD children. In conclusion, cognitive attention and WM, although delayed in FXS, reveal developmental change, rather than “arrest.” Our findings underscore the need for going beyond cross-sectional group comparisons and gross behavioral indices to map cognitive changes longitudinally in developmental disorders. En ligne : http://dx.doi.org/10.1017/S0954579412001113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199

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