[article]
| Titre : |
The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene–environment correlation: evidence from a longitudinal twin study |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Jie CHEN, Auteur ; Xinying LI, Auteur ; Matt MCGUE, Auteur |
| Article en page(s) : |
p.1066-1073 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Adolescent depressive symptoms BDNF Val66Met polymorphism stressful life events gene–environment interaction gene–environment correlation |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Confounding introduced by gene–environment correlation (rGE) may prevent one from observing a true gene–environment interaction (G × E) effect on psychopathology. The present study investigated the interacting effect of the BDNF Val66Met polymorphism and stressful life events (SLEs) on adolescent depression while controlling for the rGE by two means: separating pure environmental factors (independent SLEs) from the environmental factors under partial genetic control (dependent SLEs) and adopting a prospective longitudinal design. Methods A total of 780 pairs of Chinese twins, aged 11–17 years (mean = 13.6, SD = 1.8) at intake, were followed up twice. Self-reported depression symptoms at Time 1 and Time 2 were assessed by the Children's Depression Inventory (CDI). SLEs occurring between Time 1 and Time 2 were assessed by a self-reported checklist. SLEs were differentiated into independent and dependent ones and were validated by heritability analyses using twin design. The interacting effects between the BDNF Val66Met polymorphism and numbers of SLEs (total SLEs and independent SLEs) on intraindividual change of depression symptoms were examined. Results After controlling for sex, age, age square, and Time 1 depression, both total SLEs × BDNF Val66Met genotype and independent SLEs × BDNF Val66Met genotype significantly predicted Time 2 depression. Val allele carriers (Val/Val and Val/Met) were more susceptible to the detrimental effects of stress. Conclusions There is a true G × E effect underlying the observed interaction between BDNF Val66Met polymorphism and environmental stress on depression. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.12099 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 |
in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1066-1073
[article] The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene–environment correlation: evidence from a longitudinal twin study [Texte imprimé et/ou numérique] / Jie CHEN, Auteur ; Xinying LI, Auteur ; Matt MCGUE, Auteur . - p.1066-1073. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1066-1073
| Mots-clés : |
Adolescent depressive symptoms BDNF Val66Met polymorphism stressful life events gene–environment interaction gene–environment correlation |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Confounding introduced by gene–environment correlation (rGE) may prevent one from observing a true gene–environment interaction (G × E) effect on psychopathology. The present study investigated the interacting effect of the BDNF Val66Met polymorphism and stressful life events (SLEs) on adolescent depression while controlling for the rGE by two means: separating pure environmental factors (independent SLEs) from the environmental factors under partial genetic control (dependent SLEs) and adopting a prospective longitudinal design. Methods A total of 780 pairs of Chinese twins, aged 11–17 years (mean = 13.6, SD = 1.8) at intake, were followed up twice. Self-reported depression symptoms at Time 1 and Time 2 were assessed by the Children's Depression Inventory (CDI). SLEs occurring between Time 1 and Time 2 were assessed by a self-reported checklist. SLEs were differentiated into independent and dependent ones and were validated by heritability analyses using twin design. The interacting effects between the BDNF Val66Met polymorphism and numbers of SLEs (total SLEs and independent SLEs) on intraindividual change of depression symptoms were examined. Results After controlling for sex, age, age square, and Time 1 depression, both total SLEs × BDNF Val66Met genotype and independent SLEs × BDNF Val66Met genotype significantly predicted Time 2 depression. Val allele carriers (Val/Val and Val/Met) were more susceptible to the detrimental effects of stress. Conclusions There is a true G × E effect underlying the observed interaction between BDNF Val66Met polymorphism and environmental stress on depression. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.12099 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 |
|
The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene–environment correlation: evidence from a longitudinal twin study in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)
