Immune function genes CD99L2, JARID2 and TPO show association with autism spectrum disorder / Paula S. RAMOS in Molecular Autism, (June 2012)  

Public ISBD [article]  inMolecular Autism > (June 2012) . - 11 p. Titre : Immune function genes CD99L2, JARID2 and TPO show association with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Paula S. RAMOS, Auteur ; Satria SAJUTHI, Auteur ; Carl D. LANGEFELD, Auteur ; Stephen J. WALKER, Auteur Année de publication : 2012 Article en page(s) : 11 p. Langues : Anglais (eng) Mots-clés : Immunologie Index. décimale : PER Périodiques Résumé : Background A growing number of clinical and basic research studies have implicated immunological abnormalities as being associated with and potentially responsible for the cognitive and behavioral deficits seen in autism spectrum disorder (ASD) children. Here we test the hypothesis that immune-related gene loci are associated with ASD. Findings We identified 2,012 genes of known immune-function via Ingenuity Pathway Analysis. Family-based tests of association were computed on the 22,904 single nucleotide polymorphisms (SNPs) from the 2,012 immune-related genes on 1,510 trios available at the Autism Genetic Resource Exchange (AGRE) repository. Several SNPs in immune-related genes remained statistically significantly associated with ASD after adjusting for multiple comparisons. Specifically, we observed significant associations in the CD99 molecule-like 2 region (CD99L2, rs11796490, P = 4.01 x 10-06, OR = 0.68 (0.58-0.80)), in the jumonji AT rich interactive domain 2 (JARID2) gene (rs13193457, P = 2.71 x 10-06, OR = 0.61 (0.49-0.75)), and in the thyroid peroxidase gene (TPO) (rs1514687, P = 5.72 x 10-06, OR = 1.46 (1.24- 1.72)). Conclusions This study suggests that despite the lack of a general enrichment of SNPs in immune function genes in ASD children, several novel genes with known immune functions are associated with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-3-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Immune function genes CD99L2, JARID2 and TPO show association with autism spectrum disorder [Texte imprimé et/ou numérique] / Paula S. RAMOS, Auteur ; Satria SAJUTHI, Auteur ; Carl D. LANGEFELD, Auteur ; Stephen J. WALKER, Auteur . - 2012 . - 11 p. Langues : Anglais (eng) in Molecular Autism > (June 2012) . - 11 p. Mots-clés : Immunologie Index. décimale : PER Périodiques Résumé : Background A growing number of clinical and basic research studies have implicated immunological abnormalities as being associated with and potentially responsible for the cognitive and behavioral deficits seen in autism spectrum disorder (ASD) children. Here we test the hypothesis that immune-related gene loci are associated with ASD. Findings We identified 2,012 genes of known immune-function via Ingenuity Pathway Analysis. Family-based tests of association were computed on the 22,904 single nucleotide polymorphisms (SNPs) from the 2,012 immune-related genes on 1,510 trios available at the Autism Genetic Resource Exchange (AGRE) repository. Several SNPs in immune-related genes remained statistically significantly associated with ASD after adjusting for multiple comparisons. Specifically, we observed significant associations in the CD99 molecule-like 2 region (CD99L2, rs11796490, P = 4.01 x 10-06, OR = 0.68 (0.58-0.80)), in the jumonji AT rich interactive domain 2 (JARID2) gene (rs13193457, P = 2.71 x 10-06, OR = 0.61 (0.49-0.75)), and in the thyroid peroxidase gene (TPO) (rs1514687, P = 5.72 x 10-06, OR = 1.46 (1.24- 1.72)). Conclusions This study suggests that despite the lack of a general enrichment of SNPs in immune function genes in ASD children, several novel genes with known immune functions are associated with ASD. En ligne : http://dx.doi.org/10.1186/2040-2392-3-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

The lifetime social cost of autism: 1990–2029 / Janet CAKIR in Research in Autism Spectrum Disorders, 72 (April 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 72 (April 2020) . - p.101502 Titre : The lifetime social cost of autism: 1990–2029 Type de document : Texte imprimé et/ou numérique Auteurs : Janet CAKIR, Auteur ; Richard E. FRYE, Auteur ; Stephen J. WALKER, Auteur Article en page(s) : p.101502 Langues : Anglais (eng) Mots-clés : Autism  Autism cost  Autism rates  Autism policy  US autism  ASD Index. décimale : PER Périodiques Résumé : This cost of illness analysis computes a baseline and future estimate of lifetime social costs associated with autism spectrum disorder (ASD) for the 50 states in the United States (US). The number of cases of ASD are estimated, then multiplied by annual direct and indirect medical and non-medical costs identified in the peer-reviewed literature. This amount is then extrapolated across the number of years each cost type is expected to be incurred to calculate a total lifetime cost for each state in the US from 1990–2019, and to project future cost for 2020–2029. From 1990–2019, there have been an estimated 2 million new cases of (ASD), with social costs of more than $7 trillion. If the future prevalence of ASD remains unchanged over the next decade, there will be an estimated additional 1 million new cases, resulting in an additional $4 trillion to the United States in social costs, however if the rate of increase in prevalence continues, costs could reach nearly $15 trillion by 2029. The financial burden of ASD is significant and identifying the modifiable causes of ASD has the potential to provide tangible benefits. En ligne : https://doi.org/10.1016/j.rasd.2019.101502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] The lifetime social cost of autism: 1990–2029 [Texte imprimé et/ou numérique] / Janet CAKIR, Auteur ; Richard E. FRYE, Auteur ; Stephen J. WALKER, Auteur . - p.101502. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 72 (April 2020) . - p.101502 Mots-clés : Autism  Autism cost  Autism rates  Autism policy  US autism  ASD Index. décimale : PER Périodiques Résumé : This cost of illness analysis computes a baseline and future estimate of lifetime social costs associated with autism spectrum disorder (ASD) for the 50 states in the United States (US). The number of cases of ASD are estimated, then multiplied by annual direct and indirect medical and non-medical costs identified in the peer-reviewed literature. This amount is then extrapolated across the number of years each cost type is expected to be incurred to calculate a total lifetime cost for each state in the US from 1990–2019, and to project future cost for 2020–2029. From 1990–2019, there have been an estimated 2 million new cases of (ASD), with social costs of more than $7 trillion. If the future prevalence of ASD remains unchanged over the next decade, there will be an estimated additional 1 million new cases, resulting in an additional $4 trillion to the United States in social costs, however if the rate of increase in prevalence continues, costs could reach nearly $15 trillion by 2029. The financial burden of ASD is significant and identifying the modifiable causes of ASD has the potential to provide tangible benefits. En ligne : https://doi.org/10.1016/j.rasd.2019.101502 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

---

1 (1 - 2 / 2)