Dépouillements

An Auto ethnography of Parenting a Daughter whose Complex Disability was Diagnosed in her Adulthood / J. ALCOCK in Autism - Open Access, 6-5 ([01/09/2016])  

Public ISBD [article]  inAutism - Open Access > 6-5 [01/09/2016] . - 10 p. Titre : An Auto ethnography of Parenting a Daughter whose Complex Disability was Diagnosed in her Adulthood Type de document : Texte imprimé et/ou numérique Auteurs : J. ALCOCK, Auteur Article en page(s) : 10 p. Langues : Anglais (eng) Mots-clés : Adulthood  Auto ethnography  Complex disability  Psychology  Autism Index. décimale : PER Périodiques Résumé : This auto ethnography explores my journey as a mother of a woman with intellectual disabilities whose complex needs and behaviour has presented significant challenges to services. My biographical accounts include the experiences of receiving my daughter’s diagnoses of a rare chromosome disorder and autism in her adulthood. The former allowed a unique story which emerged from phenomena that is being swept in by the tide of the technological revolution in the detection of gene mutations and structural genomic variations causing learning disability. Within the theoretical frameworks of critical disability studies, social constructionism and family systems approaches, I weave 31 years of autobiographical accounts with cultural and structural factors that influence the experiences of parents of children with learning disabilities. Included in the investigations were the uncovering of new knowledge about the culture of intellectual disability and an examination of the events leading up to my daughter’s four-year incarceration in an institution. Evidence of oppressive, dehumanising social policies and practices intersect with new themes, including the journey from asking ‘why?’ to knowing, and chasing new ‘fixes’ to the liberating possibilities of policy changes and transformative validation. En ligne : https://dx.doi.org/10.4172/2165-7890.1000193 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] An Auto ethnography of Parenting a Daughter whose Complex Disability was Diagnosed in her Adulthood [Texte imprimé et/ou numérique] / J. ALCOCK, Auteur . - 10 p. Langues : Anglais (eng) in Autism - Open Access > 6-5 [01/09/2016] . - 10 p. Mots-clés : Adulthood  Auto ethnography  Complex disability  Psychology  Autism Index. décimale : PER Périodiques Résumé : This auto ethnography explores my journey as a mother of a woman with intellectual disabilities whose complex needs and behaviour has presented significant challenges to services. My biographical accounts include the experiences of receiving my daughter’s diagnoses of a rare chromosome disorder and autism in her adulthood. The former allowed a unique story which emerged from phenomena that is being swept in by the tide of the technological revolution in the detection of gene mutations and structural genomic variations causing learning disability. Within the theoretical frameworks of critical disability studies, social constructionism and family systems approaches, I weave 31 years of autobiographical accounts with cultural and structural factors that influence the experiences of parents of children with learning disabilities. Included in the investigations were the uncovering of new knowledge about the culture of intellectual disability and an examination of the events leading up to my daughter’s four-year incarceration in an institution. Evidence of oppressive, dehumanising social policies and practices intersect with new themes, including the journey from asking ‘why?’ to knowing, and chasing new ‘fixes’ to the liberating possibilities of policy changes and transformative validation. En ligne : https://dx.doi.org/10.4172/2165-7890.1000193 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Epigenetic Influences upon Autism Spectrum Disorder / Trevor ARCHER in Autism - Open Access, 6-5 ([01/09/2016])  

Public ISBD [article]  inAutism - Open Access > 6-5 [01/09/2016] . - 2 p. Titre : Epigenetic Influences upon Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Trevor ARCHER, Auteur Article en page(s) : 2 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Epigenetic Influences upon Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Trevor ARCHER, Auteur . - 2 p. Langues : Anglais (eng) in Autism - Open Access > 6-5 [01/09/2016] . - 2 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders / N.M. SHAKER in Autism - Open Access, 6-5 ([01/09/2016])  

Public ISBD [article]  inAutism - Open Access > 6-5 [01/09/2016] . - 7 p. Titre : Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : N.M. SHAKER, Auteur ; G.R.A TAHA, Auteur ; H. KHOLEIF, Auteur ; N.M. SAYED, Auteur ; N.M. EL-SHEIKH, Auteur ; M.L. ABULMAGD, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : ASD  Autoimmunity  S100B protein  Interleukin-6  Anti-transglutaminase antibody Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a severe neuro-developmental disorder. Various immune components and mediators have been investigated in ASD with controversial results. The purpose of this study was to: 1) investigate the levels of S100B protein (as a marker of neuronal damage), IgA autoantibodies to transglutaminase II (TG2) (as an indicator for presence of autoimmunity) and interleukin 6 (IL-6) (a pro-inflammatory cytokine), in sera of a group of autistic children, 2) explore the relation between serum levels of these parameters and severity of autism, 3) find out if there is any association between serum levels of S100B protein, IL-6 and TG2 IgA which might give clue to their pathogenic role in ASD. Methods: The levels of S100B protein, IL-6 and TG2 IgA were measured in the sera of 30 autistic children aged from 3 to 14 years. These levels were compared to those of 22 matched healthy children aged from 3 to 13 years. Assessment of clinical parameters and severity of autism was done using Gilliam Autism Rating Scale. Results: Autistic children showed higher significant serum S100B protein and IL-6 levels compared to healthy controls (P=0.003 and 0.002 respectively). No significant correlations were found between serum levels of S100B, IL-6, TG2 IgA and clinical parameters/severity of autism. Serum levels of S100B had significant negative correlation with TG2 IgA levels (P=0.037) and marginally significant positive correlation with IL-6 levels (P=0.05).Conclusion: The significant elevations of S100B and IL-6 levels in sera of autistic children possibly imply an underlying neuropathological condition in autistic patients. Anti-TG2 antibodies may not have a possible contributing role in some ASD children. More research is needed to investigate any possible link between serum S100B protein, IL-6 levels and other brain autoantibodies as potential indicators of brain autoimmunity in ASD patients. En ligne : https://dx.doi.org/10.4172/2165-7890.1000191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders [Texte imprimé et/ou numérique] / N.M. SHAKER, Auteur ; G.R.A TAHA, Auteur ; H. KHOLEIF, Auteur ; N.M. SAYED, Auteur ; N.M. EL-SHEIKH, Auteur ; M.L. ABULMAGD, Auteur . - 7 p. Langues : Anglais (eng) in Autism - Open Access > 6-5 [01/09/2016] . - 7 p. Mots-clés : ASD  Autoimmunity  S100B protein  Interleukin-6  Anti-transglutaminase antibody Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a severe neuro-developmental disorder. Various immune components and mediators have been investigated in ASD with controversial results. The purpose of this study was to: 1) investigate the levels of S100B protein (as a marker of neuronal damage), IgA autoantibodies to transglutaminase II (TG2) (as an indicator for presence of autoimmunity) and interleukin 6 (IL-6) (a pro-inflammatory cytokine), in sera of a group of autistic children, 2) explore the relation between serum levels of these parameters and severity of autism, 3) find out if there is any association between serum levels of S100B protein, IL-6 and TG2 IgA which might give clue to their pathogenic role in ASD. Methods: The levels of S100B protein, IL-6 and TG2 IgA were measured in the sera of 30 autistic children aged from 3 to 14 years. These levels were compared to those of 22 matched healthy children aged from 3 to 13 years. Assessment of clinical parameters and severity of autism was done using Gilliam Autism Rating Scale. Results: Autistic children showed higher significant serum S100B protein and IL-6 levels compared to healthy controls (P=0.003 and 0.002 respectively). No significant correlations were found between serum levels of S100B, IL-6, TG2 IgA and clinical parameters/severity of autism. Serum levels of S100B had significant negative correlation with TG2 IgA levels (P=0.037) and marginally significant positive correlation with IL-6 levels (P=0.05).Conclusion: The significant elevations of S100B and IL-6 levels in sera of autistic children possibly imply an underlying neuropathological condition in autistic patients. Anti-TG2 antibodies may not have a possible contributing role in some ASD children. More research is needed to investigate any possible link between serum S100B protein, IL-6 levels and other brain autoantibodies as potential indicators of brain autoimmunity in ASD patients. En ligne : https://dx.doi.org/10.4172/2165-7890.1000191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Mitochondrial Dysfunction in Autism Spectrum Disorders / Maheen F. SIDDIQUI in Autism - Open Access, 6-5 ([01/09/2016])  

Public ISBD [article]  inAutism - Open Access > 6-5 [01/09/2016] . - 7 p. Titre : Mitochondrial Dysfunction in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Maheen F. SIDDIQUI, Auteur ; Clare ELWELL, Auteur ; Mark H. JOHNSON, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism  Mitochondrial dysfunction  Mitochondrial health  Energy metabolism  Electron transport chain  Mitochondrial deficiency Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are classified as neurodevelopmental disorders characterised by diminished social communication and interaction. Recently, evidence has accrued that a significant proportion of individuals with autism have concomitant diseases such as mitochondrial disease and abnormalities of energy generation. This has therefore led to the hypothesis that autism may be linked to mitochondrial dysfunction. We review such studies reporting decreased activity of mitochondrial electron transport chain (ETC) complexes and reduced gene expression of mitochondrial genes, in particular genes of respiratory chain complexes, in individuals with autism. Overall, the findings support the hypothesis that there is an association of ASD with impaired mitochondrial function; however, many of the studies have small sample sizes and there is variability in the techniques utilised. There is therefore a vital need to utilise novel imaging techniques, such as near-infrared spectroscopy, that will allow non-invasive measurement of metabolic markers for neuronal activity such as cytochrome c oxidase, in order to better establish the link between autism and mitochondrial dysfunction. En ligne : https://dx.doi.org/10.4172/2165-7890.1000190 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] Mitochondrial Dysfunction in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Maheen F. SIDDIQUI, Auteur ; Clare ELWELL, Auteur ; Mark H. JOHNSON, Auteur . - 7 p. Langues : Anglais (eng) in Autism - Open Access > 6-5 [01/09/2016] . - 7 p. Mots-clés : Autism  Mitochondrial dysfunction  Mitochondrial health  Energy metabolism  Electron transport chain  Mitochondrial deficiency Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are classified as neurodevelopmental disorders characterised by diminished social communication and interaction. Recently, evidence has accrued that a significant proportion of individuals with autism have concomitant diseases such as mitochondrial disease and abnormalities of energy generation. This has therefore led to the hypothesis that autism may be linked to mitochondrial dysfunction. We review such studies reporting decreased activity of mitochondrial electron transport chain (ETC) complexes and reduced gene expression of mitochondrial genes, in particular genes of respiratory chain complexes, in individuals with autism. Overall, the findings support the hypothesis that there is an association of ASD with impaired mitochondrial function; however, many of the studies have small sample sizes and there is variability in the techniques utilised. There is therefore a vital need to utilise novel imaging techniques, such as near-infrared spectroscopy, that will allow non-invasive measurement of metabolic markers for neuronal activity such as cytochrome c oxidase, in order to better establish the link between autism and mitochondrial dysfunction. En ligne : https://dx.doi.org/10.4172/2165-7890.1000190 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410