A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABAA Receptors / Jing-Qiong KANG in Journal of Autism and Developmental Disorders, 43-1 (January 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.68-79 Titre : A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABAA Receptors Type de document : Texte imprimé et/ou numérique Auteurs : Jing-Qiong KANG, Auteur ; Gregory BARNES, Auteur Article en page(s) : p.68-79 Langues : Anglais (eng) Mots-clés : Autism  Epilepsy  Co-morbidity  GABAA receptor  Brain development  Synaptogenesis Index. décimale : PER Périodiques Résumé : Autism and epilepsy are common childhood neurological disorders with a great heterogeneity of clinical phenotypes as well as risk factors. There is a high co-morbidity of autism and epilepsy. The neuropathology of autism and epilepsy has similar histology implicating the processes of neurogenesis, neural migration, programmed cell death, and neurite outgrowth. Genetic advances have identified multiple molecules that participate in neural development, brain network connectivity, and synaptic function which are involved in the pathogenesis of autism and epilepsy. Mutations in GABAA receptor subunit have been frequently associated with epilepsy, autism, and other neuropsychiatric disorders. In this paper, we address the hypothesis that functional deficiency of GABAergic signaling is a potential common molecular mechanism underpinning the co-morbidity of autism and epilepsy. En ligne : http://dx.doi.org/10.1007/s10803-012-1543-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 [article] A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABAA Receptors [Texte imprimé et/ou numérique] / Jing-Qiong KANG, Auteur ; Gregory BARNES, Auteur . - p.68-79. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.68-79 Mots-clés : Autism  Epilepsy  Co-morbidity  GABAA receptor  Brain development  Synaptogenesis Index. décimale : PER Périodiques Résumé : Autism and epilepsy are common childhood neurological disorders with a great heterogeneity of clinical phenotypes as well as risk factors. There is a high co-morbidity of autism and epilepsy. The neuropathology of autism and epilepsy has similar histology implicating the processes of neurogenesis, neural migration, programmed cell death, and neurite outgrowth. Genetic advances have identified multiple molecules that participate in neural development, brain network connectivity, and synaptic function which are involved in the pathogenesis of autism and epilepsy. Mutations in GABAA receptor subunit have been frequently associated with epilepsy, autism, and other neuropsychiatric disorders. In this paper, we address the hypothesis that functional deficiency of GABAergic signaling is a potential common molecular mechanism underpinning the co-morbidity of autism and epilepsy. En ligne : http://dx.doi.org/10.1007/s10803-012-1543-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187

Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical / Charisma R. SHAH in Autism Research, 6-3 (June 2013)  

Public ISBD [article]  inAutism Research > 6-3 (June 2013) . - p.212-220 Titre : Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical Type de document : Texte imprimé et/ou numérique Auteurs : Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Année de publication : 2013 Article en page(s) : p.212-220 Langues : Anglais (eng) Mots-clés : animal models  behavioral analysis of animal models??animal models  genetics  gamma-aminobutyric acid neurochemistry Index. décimale : PER Périodiques Résumé : Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a “typical” way. We hypothesized that mice could be used to make a similar judgment if they prefer “typical” over “atypical” social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as “judges” and evaluated their preference for a chamber containing a “typical” (B6 or 129S6) or an “atypical” mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P??0.0001), with B6 mice preferring the typical mouse chamber during the last 10?min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P?=?0.0007; Gabrb3 +/? vs. 129S6, P?=?0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P?=?0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P?=?0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P?=?0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. En ligne : http://dx.doi.org/10.1002/aur.1280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Letting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical [Texte imprimé et/ou numérique] / Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - 2013 . - p.212-220. Langues : Anglais (eng) in Autism Research > 6-3 (June 2013) . - p.212-220 Mots-clés : animal models  behavioral analysis of animal models??animal models  genetics  gamma-aminobutyric acid neurochemistry Index. décimale : PER Périodiques Résumé : Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a “typical” way. We hypothesized that mice could be used to make a similar judgment if they prefer “typical” over “atypical” social interactions with mouse models relevant to ASD. We used wild-type C57BL/6 (B6) mice as “judges” and evaluated their preference for a chamber containing a “typical” (B6 or 129S6) or an “atypical” mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P??0.0001), with B6 mice preferring the typical mouse chamber during the last 10?min of the 30-min test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P?=?0.0007; Gabrb3 +/? vs. 129S6, P?=?0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P?=?0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P?=?0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P?=?0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. En ligne : http://dx.doi.org/10.1002/aur.1280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical / Charisma R. SHAH in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.120-120 Titre : Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical Type de document : Texte imprimé et/ou numérique Auteurs : Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.120-120 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical [Texte imprimé et/ou numérique] / Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.120-120. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.120-120 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

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