Dépouillements

Issue Information in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.0 Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.0 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1415 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Issue Information [Texte imprimé et/ou numérique] . - p.0. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.0 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1415 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Mapping Collaboration Networks in the World of Autism Research / Neal D. GOLDSTEIN in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.1-8 Titre : Mapping Collaboration Networks in the World of Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Neal D. GOLDSTEIN, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.1-8 Langues : Anglais (eng) Mots-clés : autism  collaboration  IMFAR  network  abstract  geocode Index. décimale : PER Périodiques Résumé : In the era of globalization and with the emergence of autism spectrum disorder as a global concern, the landscape of autism research has expanded to encompass much of the world. Here, we seek to provide an overview of the world of autism research, by documenting collaboration underlying the International Meeting for Autism Research (IMFAR), the pre-eminent annual scientific meeting devoted to the presentation of the latest autism research. We analyzed published abstracts presented at IMFAR meetings, between 2008 and 2013, to determine patterns of collaboration. We described collaboration networks on the individual, institutional, and international levels, and visually depicted these results on spatial network maps. Consistent with findings from other scientific disciplines, we found that collaboration is correlated with research productivity. Collaborative hotspots of autism research throughout the years were clustered on the East and West coasts of the U.S., Canada, and northern Europe. In years when conferences were held outside of North America, the proportion of abstracts from Europe and Asia increased. While IMFAR has traditionally been dominated by a large North American presence, greater global representation may be attained by shifting meeting locations to other regions of the world. En ligne : http://dx.doi.org/10.1002/aur.1393 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Mapping Collaboration Networks in the World of Autism Research [Texte imprimé et/ou numérique] / Neal D. GOLDSTEIN, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Brian K. LEE, Auteur . - p.1-8. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.1-8 Mots-clés : autism  collaboration  IMFAR  network  abstract  geocode Index. décimale : PER Périodiques Résumé : In the era of globalization and with the emergence of autism spectrum disorder as a global concern, the landscape of autism research has expanded to encompass much of the world. Here, we seek to provide an overview of the world of autism research, by documenting collaboration underlying the International Meeting for Autism Research (IMFAR), the pre-eminent annual scientific meeting devoted to the presentation of the latest autism research. We analyzed published abstracts presented at IMFAR meetings, between 2008 and 2013, to determine patterns of collaboration. We described collaboration networks on the individual, institutional, and international levels, and visually depicted these results on spatial network maps. Consistent with findings from other scientific disciplines, we found that collaboration is correlated with research productivity. Collaborative hotspots of autism research throughout the years were clustered on the East and West coasts of the U.S., Canada, and northern Europe. In years when conferences were held outside of North America, the proportion of abstracts from Europe and Asia increased. While IMFAR has traditionally been dominated by a large North American presence, greater global representation may be attained by shifting meeting locations to other regions of the world. En ligne : http://dx.doi.org/10.1002/aur.1393 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Emotion Regulation in Children and Adolescents With Autism Spectrum Disorder / Andrea C. SAMSON in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.9-18 Titre : Emotion Regulation in Children and Adolescents With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Andrea C. SAMSON, Auteur ; Antonio Y. HARDAN, Auteur ; Rebecca W. PODELL, Auteur ; Jennifer M. PHILLIPS, Auteur ; James J. GROSS, Auteur Article en page(s) : p.9-18 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  emotional reactivity  emotion regulation  cognitive reappraisal  suppression Index. décimale : PER Périodiques Résumé : Emotion dysregulation is not a formal criterion for the diagnosis of autism spectrum disorder (ASD). However, parents and clinicians have long noted the importance of emotional problems in individuals with ASD (e.g. tantrums and “meltdowns”). In this study, 21 high-functioning children and adolescents with ASD and 22 age and gender group-matched typically developing (TD) controls completed a Reactivity and Regulation Situation Task. This task assesses emotional reactivity and spontaneous use of emotion regulation strategies (problem solving, cognitive reappraisal, avoidance, distraction, venting, suppression, and relaxation) in the context of age-appropriate ambiguous and potentially threatening negative scenarios. After the concept of cognitive reappraisal was explained, the scenarios were presented again to participants, and they were prompted to use this strategy. Results indicated that individuals with ASD exhibited the same level of reactivity to negative stimuli as TD participants. Furthermore, youth with ASD had a different emotion regulation profile than TD individuals, characterized by a less frequent use of cognitive reappraisal and more frequent use of suppression. When prompted to use cognitive reappraisal, participants with ASD were less able to implement reappraisal, but benefitted from this strategy when they were able to generate a reappraisal. Findings from this study suggest that cognitive reappraisal strategies may be useful to children and adolescents with ASD. Therefore, the development of treatment programs that focus on enhancing the use of adaptive forms of emotion regulation might decrease emotional problems and optimize long-term outcomes in youth with ASD. En ligne : http://dx.doi.org/10.1002/aur.1387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Emotion Regulation in Children and Adolescents With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Andrea C. SAMSON, Auteur ; Antonio Y. HARDAN, Auteur ; Rebecca W. PODELL, Auteur ; Jennifer M. PHILLIPS, Auteur ; James J. GROSS, Auteur . - p.9-18. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.9-18 Mots-clés : autism spectrum disorder  emotional reactivity  emotion regulation  cognitive reappraisal  suppression Index. décimale : PER Périodiques Résumé : Emotion dysregulation is not a formal criterion for the diagnosis of autism spectrum disorder (ASD). However, parents and clinicians have long noted the importance of emotional problems in individuals with ASD (e.g. tantrums and “meltdowns”). In this study, 21 high-functioning children and adolescents with ASD and 22 age and gender group-matched typically developing (TD) controls completed a Reactivity and Regulation Situation Task. This task assesses emotional reactivity and spontaneous use of emotion regulation strategies (problem solving, cognitive reappraisal, avoidance, distraction, venting, suppression, and relaxation) in the context of age-appropriate ambiguous and potentially threatening negative scenarios. After the concept of cognitive reappraisal was explained, the scenarios were presented again to participants, and they were prompted to use this strategy. Results indicated that individuals with ASD exhibited the same level of reactivity to negative stimuli as TD participants. Furthermore, youth with ASD had a different emotion regulation profile than TD individuals, characterized by a less frequent use of cognitive reappraisal and more frequent use of suppression. When prompted to use cognitive reappraisal, participants with ASD were less able to implement reappraisal, but benefitted from this strategy when they were able to generate a reappraisal. Findings from this study suggest that cognitive reappraisal strategies may be useful to children and adolescents with ASD. Therefore, the development of treatment programs that focus on enhancing the use of adaptive forms of emotion regulation might decrease emotional problems and optimize long-term outcomes in youth with ASD. En ligne : http://dx.doi.org/10.1002/aur.1387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Inactivation of the Catalytic Phosphatase Domain of PTPRT/RPTP? Increases Social Interaction in Mice / Keerthi THIRTAMARA RAJAMANI in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.19-28 Titre : Inactivation of the Catalytic Phosphatase Domain of PTPRT/RPTP? Increases Social Interaction in Mice Type de document : Texte imprimé et/ou numérique Auteurs : Keerthi THIRTAMARA RAJAMANI, Auteur ; Brian O'NEILL, Auteur ; Dawn D. HAN, Auteur ; Adrienne FROSTHOLM, Auteur ; Andrej ROTTER, Auteur ; Howard H. GU, Auteur Article en page(s) : p.19-28 Langues : Anglais (eng) Mots-clés : PTPRT  RPTP?  social interaction  animal model Index. décimale : PER Périodiques Résumé : Receptor protein tyrosine phosphatase rho (RPTP?, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum. It has an extracellular domain that interacts with other cell adhesion molecules, and it has two intracellular phosphatase domains, one of which is catalytically active. In a recent genome-wide association study, PTPRT was identified as a potential candidate gene for autism spectrum disorder (ASD) susceptibility. Mutation of a critical aspartate to alanine (D1046A) in the PTPRT catalytic domain inactivates phosphatase function but retains substrate binding. We have generated a knockin mouse line carrying the PTPRT D1046A mutation. The D1046A mutation in homozygous knockin mice did not significantly change locomotor activities or anxiety-related behaviors. In contrast, male homozygous mice had significantly higher social approach scores than wild-type animals. Our results suggest that PTPRT phosphatase function is important in modulating neural pathways involved in mouse social behaviors relevant to the symptoms in human ASD patients. Autism Res 2015, 8: 19–28. En ligne : http://dx.doi.org/10.1002/aur.1390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Inactivation of the Catalytic Phosphatase Domain of PTPRT/RPTP? Increases Social Interaction in Mice [Texte imprimé et/ou numérique] / Keerthi THIRTAMARA RAJAMANI, Auteur ; Brian O'NEILL, Auteur ; Dawn D. HAN, Auteur ; Adrienne FROSTHOLM, Auteur ; Andrej ROTTER, Auteur ; Howard H. GU, Auteur . - p.19-28. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.19-28 Mots-clés : PTPRT  RPTP?  social interaction  animal model Index. décimale : PER Périodiques Résumé : Receptor protein tyrosine phosphatase rho (RPTP?, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum. It has an extracellular domain that interacts with other cell adhesion molecules, and it has two intracellular phosphatase domains, one of which is catalytically active. In a recent genome-wide association study, PTPRT was identified as a potential candidate gene for autism spectrum disorder (ASD) susceptibility. Mutation of a critical aspartate to alanine (D1046A) in the PTPRT catalytic domain inactivates phosphatase function but retains substrate binding. We have generated a knockin mouse line carrying the PTPRT D1046A mutation. The D1046A mutation in homozygous knockin mice did not significantly change locomotor activities or anxiety-related behaviors. In contrast, male homozygous mice had significantly higher social approach scores than wild-type animals. Our results suggest that PTPRT phosphatase function is important in modulating neural pathways involved in mouse social behaviors relevant to the symptoms in human ASD patients. Autism Res 2015, 8: 19–28. En ligne : http://dx.doi.org/10.1002/aur.1390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Time Reproduction Performance Is Associated With Age and Working Memory in High-Functioning Youth With Autism Spectrum Disorder / Laurie A. BRENNER in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.29-37 Titre : Time Reproduction Performance Is Associated With Age and Working Memory in High-Functioning Youth With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Laurie A. BRENNER, Auteur ; Vivian H. SHIH, Auteur ; Natalie L. COLICH, Auteur ; Catherine A. SUGAR, Auteur ; Carrie E. BEARDEN, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.29-37 Langues : Anglais (eng) Mots-clés : temporal processing  time estimation  inattention/hyperactivity Index. décimale : PER Périodiques Résumé : Impaired temporal processing has historically been viewed as a hallmark feature of attention deficit hyperactivity disorder. Recent evidence suggests temporal processing deficits may also be characteristic of autism spectrum disorder (ASD). However, little is known about the factors that impact temporal processing in children with ASD. The purpose of this study was to assess the effects of co-morbid attention problems, working memory (WM), age, and their interactions, on time reproduction in youth with and without ASD. Twenty-seven high-functioning individuals with ASD and 25 demographically comparable typically developing individuals (ages 9–17; 85% male) were assessed on measures of time reproduction, auditory WM, and inattention/hyperactivity. The time reproduction task required depression of a computer key to mimic interval durations of 4, 8, 12, 16, or 20?sec. Mixed effects regression analyses were used to model accuracy and variability of time reproduction as functions of diagnostic group, interval duration, age, WM, and inattention/hyperactivity. A significant group by age interaction was detected for accuracy, with the deficit in the ASD group being greater in younger children. There was a significant group by WM interaction for consistency, with the effects of poor WM on performance consistency being more pronounced in youth with ASD. All participants tended to underestimate longer interval durations and to be less consistent for shorter interval durations; these effects appeared more pronounced in those who were younger or who had poorer WM performance. Inattention/hyperactivity symptoms in the ASD group were not related to either accuracy or consistency. This study highlights the potential value of temporal processing as an intermediate trait of relevance to multiple neurodevelopmental disorders. Autism Res 2015, 8: 29–37. En ligne : http://dx.doi.org/10.1002/aur.1401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Time Reproduction Performance Is Associated With Age and Working Memory in High-Functioning Youth With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Laurie A. BRENNER, Auteur ; Vivian H. SHIH, Auteur ; Natalie L. COLICH, Auteur ; Catherine A. SUGAR, Auteur ; Carrie E. BEARDEN, Auteur ; Mirella DAPRETTO, Auteur . - p.29-37. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.29-37 Mots-clés : temporal processing  time estimation  inattention/hyperactivity Index. décimale : PER Périodiques Résumé : Impaired temporal processing has historically been viewed as a hallmark feature of attention deficit hyperactivity disorder. Recent evidence suggests temporal processing deficits may also be characteristic of autism spectrum disorder (ASD). However, little is known about the factors that impact temporal processing in children with ASD. The purpose of this study was to assess the effects of co-morbid attention problems, working memory (WM), age, and their interactions, on time reproduction in youth with and without ASD. Twenty-seven high-functioning individuals with ASD and 25 demographically comparable typically developing individuals (ages 9–17; 85% male) were assessed on measures of time reproduction, auditory WM, and inattention/hyperactivity. The time reproduction task required depression of a computer key to mimic interval durations of 4, 8, 12, 16, or 20?sec. Mixed effects regression analyses were used to model accuracy and variability of time reproduction as functions of diagnostic group, interval duration, age, WM, and inattention/hyperactivity. A significant group by age interaction was detected for accuracy, with the deficit in the ASD group being greater in younger children. There was a significant group by WM interaction for consistency, with the effects of poor WM on performance consistency being more pronounced in youth with ASD. All participants tended to underestimate longer interval durations and to be less consistent for shorter interval durations; these effects appeared more pronounced in those who were younger or who had poorer WM performance. Inattention/hyperactivity symptoms in the ASD group were not related to either accuracy or consistency. This study highlights the potential value of temporal processing as an intermediate trait of relevance to multiple neurodevelopmental disorders. Autism Res 2015, 8: 29–37. En ligne : http://dx.doi.org/10.1002/aur.1401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Motor Learning in Individuals With Autism Spectrum Disorder: Activation in Superior Parietal Lobule Related to Learning and Repetitive Behaviors / Brittany G. TRAVERS in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.38-51 Titre : Motor Learning in Individuals With Autism Spectrum Disorder: Activation in Superior Parietal Lobule Related to Learning and Repetitive Behaviors Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Rajesh K. KANA, Auteur ; Laura G. KLINGER, Auteur ; Christopher L. KLEIN, Auteur ; Mark R. KLINGER, Auteur Article en page(s) : p.38-51 Langues : Anglais (eng) Mots-clés : autism  motor learning  implicit learning  procedural learning  superior parietal  repetitive behaviors Index. décimale : PER Périodiques Résumé : Motor-linked implicit learning is the learning of a sequence of movements without conscious awareness. Although motor symptoms are frequently reported in individuals with autism spectrum disorder (ASD), recent behavioral studies have suggested that motor-linked implicit learning may be intact in ASD. The serial reaction time (SRT) task is one of the most common measures of motor-linked implicit learning. The present study used a 3T functional magnetic resonance imaging scanner to examine the behavioral and neural correlates of real-time motor sequence learning in adolescents and adults with ASD (n?=?15) compared with age- and intelligence quotient-matched individuals with typical development (n?=?15) during an SRT task. Behavioral results suggested less robust motor sequence learning in individuals with ASD. Group differences in brain activation suggested that individuals with ASD, relative to individuals with typical development, showed decreased activation in the right superior parietal lobule (SPL) and right precuneus (Brodmann areas 5 and 7, and extending into the intraparietal sulcus) during learning. Activation in these areas (and in areas such as the right putamen and right supramarginal gyrus) was found to be significantly related to behavioral learning in this task. Additionally, individuals with ASD who had more severe repetitive behavior/restricted interest symptoms demonstrated greater decreased activation in these regions during motor learning. In conjunction, these results suggest that the SPL may play an important role in motor learning and repetitive behavior in individuals with ASD. Autism Res 2015, 8: 38–51. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1403 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Motor Learning in Individuals With Autism Spectrum Disorder: Activation in Superior Parietal Lobule Related to Learning and Repetitive Behaviors [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Rajesh K. KANA, Auteur ; Laura G. KLINGER, Auteur ; Christopher L. KLEIN, Auteur ; Mark R. KLINGER, Auteur . - p.38-51. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.38-51 Mots-clés : autism  motor learning  implicit learning  procedural learning  superior parietal  repetitive behaviors Index. décimale : PER Périodiques Résumé : Motor-linked implicit learning is the learning of a sequence of movements without conscious awareness. Although motor symptoms are frequently reported in individuals with autism spectrum disorder (ASD), recent behavioral studies have suggested that motor-linked implicit learning may be intact in ASD. The serial reaction time (SRT) task is one of the most common measures of motor-linked implicit learning. The present study used a 3T functional magnetic resonance imaging scanner to examine the behavioral and neural correlates of real-time motor sequence learning in adolescents and adults with ASD (n?=?15) compared with age- and intelligence quotient-matched individuals with typical development (n?=?15) during an SRT task. Behavioral results suggested less robust motor sequence learning in individuals with ASD. Group differences in brain activation suggested that individuals with ASD, relative to individuals with typical development, showed decreased activation in the right superior parietal lobule (SPL) and right precuneus (Brodmann areas 5 and 7, and extending into the intraparietal sulcus) during learning. Activation in these areas (and in areas such as the right putamen and right supramarginal gyrus) was found to be significantly related to behavioral learning in this task. Additionally, individuals with ASD who had more severe repetitive behavior/restricted interest symptoms demonstrated greater decreased activation in these regions during motor learning. In conjunction, these results suggest that the SPL may play an important role in motor learning and repetitive behavior in individuals with ASD. Autism Res 2015, 8: 38–51. © 2014 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1403 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Impaired Identification of Impoverished Animate but not Inanimate Objects in Adults With High-Functioning Autism Spectrum Disorder / Hollie G. BURNETT in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.52-60 Titre : Impaired Identification of Impoverished Animate but not Inanimate Objects in Adults With High-Functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Hollie G. BURNETT, Auteur ; Sven PANIS, Auteur ; Johan WAGEMANS, Auteur ; Tjeerd JELLEMA, Auteur Article en page(s) : p.52-60 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD)  concept forming  Gabor  impoverished objects  animate  inanimate Index. décimale : PER Périodiques Résumé : The ability to identify animate and inanimate objects from impoverished images was investigated in adults with high-functioning autism spectrum disorder (HFA) and in matched typically developed (TD) adults, using a newly developed task. Consecutive frames were presented containing Gabor elements that slightly changed orientation from one frame to the next. For a subset of elements, the changes were such that these elements gradually formed the outline of an object. Elements enclosed within the object's outline gradually adopted one and the same orientation, outside elements adopted random orientations. The subjective experience was that of an object appearing out of a fog. The HFA group required significantly more frames to identify the impoverished objects than the TD group. Crucially, this difference depended on the nature of the objects: the HFA group required significantly more frames to identify animate objects, but with respect to the identification of inanimate objects the groups did not differ. The groups also did not differ with respect to the number and type of incorrect guesses they made. The results suggest a specific impairment in individuals with HFA in identifying animate objects. A number of possible explanations are discussed. Autism Res 2015, 8: 52–60. En ligne : http://dx.doi.org/10.1002/aur.1412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Impaired Identification of Impoverished Animate but not Inanimate Objects in Adults With High-Functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Hollie G. BURNETT, Auteur ; Sven PANIS, Auteur ; Johan WAGEMANS, Auteur ; Tjeerd JELLEMA, Auteur . - p.52-60. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.52-60 Mots-clés : autism spectrum disorder (ASD)  concept forming  Gabor  impoverished objects  animate  inanimate Index. décimale : PER Périodiques Résumé : The ability to identify animate and inanimate objects from impoverished images was investigated in adults with high-functioning autism spectrum disorder (HFA) and in matched typically developed (TD) adults, using a newly developed task. Consecutive frames were presented containing Gabor elements that slightly changed orientation from one frame to the next. For a subset of elements, the changes were such that these elements gradually formed the outline of an object. Elements enclosed within the object's outline gradually adopted one and the same orientation, outside elements adopted random orientations. The subjective experience was that of an object appearing out of a fog. The HFA group required significantly more frames to identify the impoverished objects than the TD group. Crucially, this difference depended on the nature of the objects: the HFA group required significantly more frames to identify animate objects, but with respect to the identification of inanimate objects the groups did not differ. The groups also did not differ with respect to the number and type of incorrect guesses they made. The results suggest a specific impairment in individuals with HFA in identifying animate objects. A number of possible explanations are discussed. Autism Res 2015, 8: 52–60. En ligne : http://dx.doi.org/10.1002/aur.1412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder / Daniel PETERSON in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.61-72 Titre : Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Daniel PETERSON, Auteur ; Rajneesh MAHAJAN, Auteur ; Deana CROCETTI, Auteur ; Amanda MEJIA, Auteur ; Stewart MOSTOFSKY, Auteur Article en page(s) : p.61-72 Langues : Anglais (eng) Mots-clés : diffusion tensor imaging (DTI)  neuroimaging  laterality  white matter Index. décimale : PER Périodiques Résumé : Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. Autism Res 2015, 8: 61–72. En ligne : http://dx.doi.org/10.1002/aur.1413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Left-Hemispheric Microstructural Abnormalities in Children With High-Functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Daniel PETERSON, Auteur ; Rajneesh MAHAJAN, Auteur ; Deana CROCETTI, Auteur ; Amanda MEJIA, Auteur ; Stewart MOSTOFSKY, Auteur . - p.61-72. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.61-72 Mots-clés : diffusion tensor imaging (DTI)  neuroimaging  laterality  white matter Index. décimale : PER Périodiques Résumé : Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD. Autism Res 2015, 8: 61–72. En ligne : http://dx.doi.org/10.1002/aur.1413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Evidence for ASD Recurrence Rates and Reproductive Stoppage From Large UK ASD Research Family Databases / Claire L. WOOD in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.73-81 Titre : Evidence for ASD Recurrence Rates and Reproductive Stoppage From Large UK ASD Research Family Databases Type de document : Texte imprimé et/ou numérique Auteurs : Claire L. WOOD, Auteur ; Frances WARNELL, Auteur ; Mary JOHNSON, Auteur ; Annette HAMES, Auteur ; Mark S. PEARCE, Auteur ; Helen MCCONACHIE, Auteur ; Jeremy R. PARR, Auteur Article en page(s) : p.73-81 Langues : Anglais (eng) Mots-clés : autism  ASD  genetics  recurrence  stoppage Index. décimale : PER Périodiques Résumé : Following a diagnosis of a developmental disorder such as autism spectrum disorder (ASD) in early childhood, parents may decide to have fewer children than previously planned. The tendency for families to halt reproduction after receiving a diagnosis for one child is known as reproductive stoppage. Stoppage may lead to an underestimate of recurrence risk estimates of parents having more than one child with ASD. Using two large UK ASD family databases, we investigated recurrence rates for ASD and evidence for reproductive stoppage for both ASD and undiagnosed ASD/broader autism phenotype in a subgroup of families. Reproductive stoppage was tested for using the Mann–Whitney U-test to disprove the null hypothesis that affected and nonaffected children were distributed randomly by birth order. Dahlberg's later-sib method was used to estimate recurrence risk and take stoppage into account. Data were available from 299 families (660 children) including 327 with ASD. Ten percent of the complete families had more than one child with an ASD. Using Dahlberg's later-sib method, the recurrence risk for ASD was 24.7% overall and 50.0% in families with two or more older siblings with ASD. Children with ASD were born significantly later in families than those without ASD in all sibship combinations. This study shows strong evidence that ASD is associated with reproductive stoppage. These data have important implications for family planning and genetic counseling. Autism Res 2015, 8: 73–81. En ligne : http://dx.doi.org/10.1002/aur.1414 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Evidence for ASD Recurrence Rates and Reproductive Stoppage From Large UK ASD Research Family Databases [Texte imprimé et/ou numérique] / Claire L. WOOD, Auteur ; Frances WARNELL, Auteur ; Mary JOHNSON, Auteur ; Annette HAMES, Auteur ; Mark S. PEARCE, Auteur ; Helen MCCONACHIE, Auteur ; Jeremy R. PARR, Auteur . - p.73-81. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.73-81 Mots-clés : autism  ASD  genetics  recurrence  stoppage Index. décimale : PER Périodiques Résumé : Following a diagnosis of a developmental disorder such as autism spectrum disorder (ASD) in early childhood, parents may decide to have fewer children than previously planned. The tendency for families to halt reproduction after receiving a diagnosis for one child is known as reproductive stoppage. Stoppage may lead to an underestimate of recurrence risk estimates of parents having more than one child with ASD. Using two large UK ASD family databases, we investigated recurrence rates for ASD and evidence for reproductive stoppage for both ASD and undiagnosed ASD/broader autism phenotype in a subgroup of families. Reproductive stoppage was tested for using the Mann–Whitney U-test to disprove the null hypothesis that affected and nonaffected children were distributed randomly by birth order. Dahlberg's later-sib method was used to estimate recurrence risk and take stoppage into account. Data were available from 299 families (660 children) including 327 with ASD. Ten percent of the complete families had more than one child with an ASD. Using Dahlberg's later-sib method, the recurrence risk for ASD was 24.7% overall and 50.0% in families with two or more older siblings with ASD. Children with ASD were born significantly later in families than those without ASD in all sibship combinations. This study shows strong evidence that ASD is associated with reproductive stoppage. These data have important implications for family planning and genetic counseling. Autism Res 2015, 8: 73–81. En ligne : http://dx.doi.org/10.1002/aur.1414 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6–35 Years / Nicholas LANGE in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.82-93 Titre : Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6–35 Years Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas LANGE, Auteur ; Brittany G. TRAVERS, Auteur ; Erin D. BIGLER, Auteur ; Molly B. D. PRIGGE, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Annahir N. CARIELLO, Auteur ; Brandon A. ZIELINSKI, Auteur ; Jeffrey S. ANDERSON, Auteur ; P. Thomas FLETCHER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Article en page(s) : p.82-93 Langues : Anglais (eng) Mots-clés : adolescents  adults  children  growth curve  mixed effects  MRI  variance Index. décimale : PER Périodiques Résumé : Since the impairments associated with autism spectrum disorder (ASD) tend to persist or worsen from childhood into adulthood, it is of critical importance to examine how the brain develops over this growth epoch. We report initial findings on whole and regional longitudinal brain development in 100 male participants with ASD (226 high-quality magnetic resonance imaging [MRI] scans; mean inter-scan interval 2.7 years) compared to 56 typically developing controls (TDCs) (117 high-quality scans; mean inter-scan interval 2.6 years) from childhood into adulthood, for a total of 156 participants scanned over an 8-year period. This initial analysis includes between one and three high-quality scans per participant that have been processed and segmented to date, with 21% having one scan, 27% with two scans, and 52% with three scans in the ASD sample; corresponding percentages for the TDC sample are 30%, 30%, and 40%. The proportion of participants with multiple scans (79% of ASDs and 68% of TDCs) was high in comparison to that of large longitudinal neuroimaging studies of typical development. We provide volumetric growth curves for the entire brain, total gray matter (GM), frontal GM, temporal GM, parietal GM, occipital GM, total cortical white matter (WM), corpus callosum, caudate, thalamus, total cerebellum, and total ventricles. Mean volume of cortical WM was reduced significantly. Mean ventricular volume was increased in the ASD sample relative to the TDCs across the broad age range studied. Decreases in regional mean volumes in the ASD sample most often were due to decreases during late adolescence and adulthood. The growth curve of whole brain volume over time showed increased volumes in young children with autism, and subsequently decreased during adolescence to meet the TDC curve between 10 and 15 years of age. The volume of many structures continued to decline atypically into adulthood in the ASD sample. The data suggest that ASD is a dynamic disorder with complex changes in whole and regional brain volumes that change over time from childhood into adulthood. Autism Res 2015, 8: 82–93. En ligne : http://dx.doi.org/10.1002/aur.1427 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6–35 Years [Texte imprimé et/ou numérique] / Nicholas LANGE, Auteur ; Brittany G. TRAVERS, Auteur ; Erin D. BIGLER, Auteur ; Molly B. D. PRIGGE, Auteur ; Alyson L. FROEHLICH, Auteur ; Jared A. NIELSEN, Auteur ; Annahir N. CARIELLO, Auteur ; Brandon A. ZIELINSKI, Auteur ; Jeffrey S. ANDERSON, Auteur ; P. Thomas FLETCHER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - p.82-93. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.82-93 Mots-clés : adolescents  adults  children  growth curve  mixed effects  MRI  variance Index. décimale : PER Périodiques Résumé : Since the impairments associated with autism spectrum disorder (ASD) tend to persist or worsen from childhood into adulthood, it is of critical importance to examine how the brain develops over this growth epoch. We report initial findings on whole and regional longitudinal brain development in 100 male participants with ASD (226 high-quality magnetic resonance imaging [MRI] scans; mean inter-scan interval 2.7 years) compared to 56 typically developing controls (TDCs) (117 high-quality scans; mean inter-scan interval 2.6 years) from childhood into adulthood, for a total of 156 participants scanned over an 8-year period. This initial analysis includes between one and three high-quality scans per participant that have been processed and segmented to date, with 21% having one scan, 27% with two scans, and 52% with three scans in the ASD sample; corresponding percentages for the TDC sample are 30%, 30%, and 40%. The proportion of participants with multiple scans (79% of ASDs and 68% of TDCs) was high in comparison to that of large longitudinal neuroimaging studies of typical development. We provide volumetric growth curves for the entire brain, total gray matter (GM), frontal GM, temporal GM, parietal GM, occipital GM, total cortical white matter (WM), corpus callosum, caudate, thalamus, total cerebellum, and total ventricles. Mean volume of cortical WM was reduced significantly. Mean ventricular volume was increased in the ASD sample relative to the TDCs across the broad age range studied. Decreases in regional mean volumes in the ASD sample most often were due to decreases during late adolescence and adulthood. The growth curve of whole brain volume over time showed increased volumes in young children with autism, and subsequently decreased during adolescence to meet the TDC curve between 10 and 15 years of age. The volume of many structures continued to decline atypically into adulthood in the ASD sample. The data suggest that ASD is a dynamic disorder with complex changes in whole and regional brain volumes that change over time from childhood into adulthood. Autism Res 2015, 8: 82–93. En ligne : http://dx.doi.org/10.1002/aur.1427 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Lack of Evidence for Genomic Instability in Autistic Children as Measured by the Cytokinesis-Block Micronucleus Cytome Assay / Penelope A. E. MAIN in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.94-104 Titre : Lack of Evidence for Genomic Instability in Autistic Children as Measured by the Cytokinesis-Block Micronucleus Cytome Assay Type de document : Texte imprimé et/ou numérique Auteurs : Penelope A. E. MAIN, Auteur ; Philip THOMAS, Auteur ; Manya T. ANGLEY, Auteur ; Robyn L. YOUNG, Auteur ; Adrian ESTERMAN, Auteur ; Catherine E. KING, Auteur ; Michael F. FENECH, Auteur Article en page(s) : p.94-104 Langues : Anglais (eng) Mots-clés : autism  genomic instability  DNA damage  B vitamins  behaviour  riboflavin Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are a set of neurodevelopmental disorders that are highly hereditable. Increased genomic instability has been observed in other heritable paediatric neurobiological disorders; therefore, the aim of our study was to test the hypothesis that DNA damage is increased in children with autism and that B vitamin status may explain variations in genome integrity between autistic and normal children. We compared 35 children with autism, 27 of their siblings without autism and 25 age- and gender-matched community controls for genomic stability using the cytokinesis-block micronucleus cytome (CBMN-cyt) assay, B vitamins and homocysteine, as well as autism-related behaviours. It was found that there were no differences in CBMN-cyt biomarkers between the three groups. Vitamin B2 was significantly raised in children with autism and their siblings compared with controls (P?=?0.027 and P?=?0.016 respectively) but there was no difference in other B vitamins or homocysteine. In conclusion, although replication using a larger cohort is needed, it appears unlikely that genomic instability is a feature of the aetiology of autism. We cannot rule out in utero effects or other types of DNA damage not measured by the CBMN-cyt assay. En ligne : http://dx.doi.org/10.1002/aur.1428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Lack of Evidence for Genomic Instability in Autistic Children as Measured by the Cytokinesis-Block Micronucleus Cytome Assay [Texte imprimé et/ou numérique] / Penelope A. E. MAIN, Auteur ; Philip THOMAS, Auteur ; Manya T. ANGLEY, Auteur ; Robyn L. YOUNG, Auteur ; Adrian ESTERMAN, Auteur ; Catherine E. KING, Auteur ; Michael F. FENECH, Auteur . - p.94-104. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.94-104 Mots-clés : autism  genomic instability  DNA damage  B vitamins  behaviour  riboflavin Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are a set of neurodevelopmental disorders that are highly hereditable. Increased genomic instability has been observed in other heritable paediatric neurobiological disorders; therefore, the aim of our study was to test the hypothesis that DNA damage is increased in children with autism and that B vitamin status may explain variations in genome integrity between autistic and normal children. We compared 35 children with autism, 27 of their siblings without autism and 25 age- and gender-matched community controls for genomic stability using the cytokinesis-block micronucleus cytome (CBMN-cyt) assay, B vitamins and homocysteine, as well as autism-related behaviours. It was found that there were no differences in CBMN-cyt biomarkers between the three groups. Vitamin B2 was significantly raised in children with autism and their siblings compared with controls (P?=?0.027 and P?=?0.016 respectively) but there was no difference in other B vitamins or homocysteine. In conclusion, although replication using a larger cohort is needed, it appears unlikely that genomic instability is a feature of the aetiology of autism. We cannot rule out in utero effects or other types of DNA damage not measured by the CBMN-cyt assay. En ligne : http://dx.doi.org/10.1002/aur.1428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Decision-Making Skills in ASD: Performance on the Iowa Gambling Task / Joanna L. MUSSEY in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.105-114 Titre : Decision-Making Skills in ASD: Performance on the Iowa Gambling Task Type de document : Texte imprimé et/ou numérique Auteurs : Joanna L. MUSSEY, Auteur ; Brittany G. TRAVERS, Auteur ; Laura Grofer KLINGER, Auteur ; Mark R. KLINGER, Auteur Article en page(s) : p.105-114 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  decision making  Iowa Gambling Task  implicit learning Index. décimale : PER Périodiques Résumé : Decision making plays a key role in daily function, but little is known regarding how individuals with autism spectrum disorder (ASD) make decisions. The present studies examined decision making in persons with ASD using the Iowa Gambling Task (IGT), a computerized card game with the goal of earning money by deciding among decks of cards. To be successful, players need to figure out which decks are associated with winning and which are associated with losing money in the long run. Results of Study 1 indicated that participants with ASD made poorer decisions and showed slower learning of which decks earned more money compared with participants with typical development. Additionally, they made more frequent shifts between decks compared with participants with typical development. In Study 2, undergraduate students with typical development completed the IGT to examine whether instructing them to make frequent shifts between decks early in the IGT would negatively impact their decision making. Results of Study 2 suggested that when participants with typical development were required to make frequent shifts, they exhibited a slower rate of learning and poorer decision making, thus emulating participants with ASD in Study 1. The combined results suggest that the way that persons with ASD explore and attend to their environment may be related to poor decision making. Implications for cognitive learning styles are discussed. Autism Res 2015, 8: 105–114. En ligne : http://dx.doi.org/10.1002/aur.1429 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Decision-Making Skills in ASD: Performance on the Iowa Gambling Task [Texte imprimé et/ou numérique] / Joanna L. MUSSEY, Auteur ; Brittany G. TRAVERS, Auteur ; Laura Grofer KLINGER, Auteur ; Mark R. KLINGER, Auteur . - p.105-114. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.105-114 Mots-clés : autism spectrum disorder  decision making  Iowa Gambling Task  implicit learning Index. décimale : PER Périodiques Résumé : Decision making plays a key role in daily function, but little is known regarding how individuals with autism spectrum disorder (ASD) make decisions. The present studies examined decision making in persons with ASD using the Iowa Gambling Task (IGT), a computerized card game with the goal of earning money by deciding among decks of cards. To be successful, players need to figure out which decks are associated with winning and which are associated with losing money in the long run. Results of Study 1 indicated that participants with ASD made poorer decisions and showed slower learning of which decks earned more money compared with participants with typical development. Additionally, they made more frequent shifts between decks compared with participants with typical development. In Study 2, undergraduate students with typical development completed the IGT to examine whether instructing them to make frequent shifts between decks early in the IGT would negatively impact their decision making. Results of Study 2 suggested that when participants with typical development were required to make frequent shifts, they exhibited a slower rate of learning and poorer decision making, thus emulating participants with ASD in Study 1. The combined results suggest that the way that persons with ASD explore and attend to their environment may be related to poor decision making. Implications for cognitive learning styles are discussed. Autism Res 2015, 8: 105–114. En ligne : http://dx.doi.org/10.1002/aur.1429 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Scientific Summaries for Families with ASD in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.115-119 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.115-119 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1476 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.115-119. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.115-119 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1476 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical / Charisma R. SHAH in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.120-120 Titre : Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical Type de document : Texte imprimé et/ou numérique Auteurs : Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.120-120 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Letting a Typical Mouse Judge whether Mouse Social Interactions Are Atypical [Texte imprimé et/ou numérique] / Charisma R. SHAH, Auteur ; Carl Gunnar FORSBERG, Auteur ; Jing-Qiong KANG, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.120-120. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.120-120 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders / Karina GRIESI-OLIVEIRA in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.121-121 Titre : Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Karina GRIESI-OLIVEIRA, Auteur ; Daniele Yumi SUNAGA, Auteur ; Lucas Alvizi CRUZ, Auteur ; Estevão VADASZ, Auteur ; Maria Rita PASSOS-BUENO, Auteur Article en page(s) : p.121-121 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Stem Cells as a Good Tool to Investigate Dysregulated Biological Systems in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Karina GRIESI-OLIVEIRA, Auteur ; Daniele Yumi SUNAGA, Auteur ; Lucas Alvizi CRUZ, Auteur ; Estevão VADASZ, Auteur ; Maria Rita PASSOS-BUENO, Auteur . - p.121-121. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.121-121 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256